2025
Brain morphology mediating the effects of common genetic risk variants on Alzheimer's disease.
Breddels E, Snihirova Y, Pishva E, Gülöksüz S, Blokland G, Luykx J, Andreassen O, Linden D, van der Meer D. Brain morphology mediating the effects of common genetic risk variants on Alzheimer's disease. Journal Of Alzheimer's Disease Reports 2025, 9: 25424823251328300. PMID: 40144144, PMCID: PMC11938454, DOI: 10.1177/25424823251328300.Peer-Reviewed Original ResearchLate-onset Alzheimer's diseaseGenetic risk variantsMendelian randomizationRisk of late-onset Alzheimer's diseaseInferior lateral ventricleUK BiobankAlzheimer's Disease Neuroimaging InitiativeCausal pathwaysAlzheimer's diseaseRisk variantsClinical dataLateral ventricleNeurobiological pathwaysBiobankAlzheimerGenetic dataDiseaseAssociated with alterationsGenetic variationBrain morphologyEntorhinal cortexRiskMeasures of brain morphology
2024
Multiomic Network Analysis Identifies Dysregulated Neurobiological Pathways in Opioid Addiction
Sullivan K, Kainer D, Lane M, Cashman M, Miller J, Garvin M, Townsend A, Quach B, Willis C, Kruse P, Gaddis N, Mathur R, Corradin O, Maher B, Scacheri P, Sanchez-Roige S, Palmer A, Troiani V, Chesler E, Kember R, Kranzler H, Justice A, Xu K, Aouizerat B, Hancock D, Johnson E, Jacobson D, Program V. Multiomic Network Analysis Identifies Dysregulated Neurobiological Pathways in Opioid Addiction. Biological Psychiatry 2024, 98: 11-22. PMID: 39615775, PMCID: PMC12119972, DOI: 10.1016/j.biopsych.2024.11.013.Peer-Reviewed Original ResearchGenome-wide association studiesSubstance use disordersOpioid use disorderAddiction treatmentOpioid addictionDorsolateral prefrontal cortexOpioid addiction treatmentMulti-omics network analysisPrefrontal cortexPrescription opioid misuseSystems biology approachNeurobiological pathwaysOpioid overdose victimsUse disorderOverdose victimsAddictionAssociation studiesEpigenetic dataOpioid misuseOpioidDLPFCERK pathwayBiology approachMulti-OmicsGene targeting
2021
Hippocampal transcriptome-wide association study and neurobiological pathway analysis for Alzheimer’s disease
Liu N, Xu J, Liu H, Zhang S, Li M, Zhou Y, Qin W, Li M, Yu C. Hippocampal transcriptome-wide association study and neurobiological pathway analysis for Alzheimer’s disease. PLOS Genetics 2021, 17: e1009363. PMID: 33630843, PMCID: PMC7906391, DOI: 10.1371/journal.pgen.1009363.Peer-Reviewed Original ResearchConceptsTranscriptome-wide association studyGenome-wide association studiesAssociation studiesAD-GWASHippocampal gene expressionGene expressionAlzheimer's diseaseMeta-analyses of GWASIdentified multiple susceptibility lociGenes associated with ADGenome-wide association dataMultiple susceptibility lociAD-related genesAmyloid beta formationHippocampal expressionSusceptibility lociAmyloid-betaNeurobiological pathwaysTranscriptome dataHippocampal volumePathway analysisGenesAssociation dataMeta-analysisCognitively normal elderly individuals
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