2022
Association of hyperglycemia and molecular subclass on survival in IDH-wildtype glioblastoma
Liu E, Vasudevaraja V, Sviderskiy V, Feng Y, Tran I, Serrano J, Cordova C, Kurz S, Golfinos J, Sulman E, Orringer D, Placantonakis D, Possemato R, Snuderl M. Association of hyperglycemia and molecular subclass on survival in IDH-wildtype glioblastoma. Neuro-Oncology Advances 2022, 4: vdac163. PMID: 36382106, PMCID: PMC9653172, DOI: 10.1093/noajnl/vdac163.Peer-Reviewed Original ResearchIDH-wt GBMAssociated with poor OSMethylation subclassesOverall survivalPoor OSIDH-wtMolecular subclassesRTK IAssociated with worse survivalAssociated with OSIDH-wildtype glioblastomaPotential survival benefitAssociation of hyperglycemiaAverage glucose valuesAverage glucoseStupp protocolDexamethasone doseMGMT statusSurvival benefitWorse survivalMesenchymal tumorsPerformance statusLow glucose levelsMGMT methylationMolecular subtypes
2021
Glycemic Control as an Early Prognostic Marker in Advanced Pancreatic Cancer
Alpertunga I, Sadiq R, Pandya D, Lo T, Dulgher M, Evans S, Bennett B, Rennert N, Frank R. Glycemic Control as an Early Prognostic Marker in Advanced Pancreatic Cancer. Frontiers In Oncology 2021, 11: 571855. PMID: 33718132, PMCID: PMC7947820, DOI: 10.3389/fonc.2021.571855.Peer-Reviewed Original ResearchAdvanced pancreatic ductal adenocarcinomaPancreatic ductal adenocarcinomaImproved overall survivalOverall survivalGlycemic controlCA 19Serum tumor markers CA 19Cox proportional hazards regression modelProportional hazards regression modelsTumor marker CA 19Random blood glucose valuesEarly glycemic controlAdvanced pancreatic cancerPresence of diabetesCohort of patientsMonths of treatmentEarly prognostic markerImpaired glucose metabolismLog-rank testHazards regression modelsKaplan-Meier estimatesLarge patient cohortNovel prognostic biomarkerBlood glucose valuesLow glucose levels
2014
Safety of Nighttime 2-Hour Suspension of Basal Insulin in Pump-Treated Type 1 Diabetes Even in the Absence of Low Glucose
Sherr JL, Collazo M, Cengiz E, Michaud C, Carria L, Steffen AT, Weyman K, Zgorski M, Tichy E, Tamborlane WV, Weinzimer SA. Safety of Nighttime 2-Hour Suspension of Basal Insulin in Pump-Treated Type 1 Diabetes Even in the Absence of Low Glucose. Diabetes Care 2014, 37: 773-779. PMID: 24170766, PMCID: PMC3931387, DOI: 10.2337/dc13-1608.Peer-Reviewed Original ResearchConceptsBlood β-hydroxybutyrate levelsΒ-hydroxybutyrate levelsBasal insulinBlood glucose levelsBasal insulin infusionGlucose levelsBlood glucoseInsulin infusionMorning blood glucose levelsType 1 diabetic subjectsUsual basal ratesBasal rateLow glucose levelsSignificant ketonemiaDiabetic ketoacidosisDiabetic subjectsControl nightSensor-augmented pump systemGlucose valuesType 1Experimental nightInsulinLow glucoseNext morningInfusion
2009
Glucose Normalization and Outcomes in Patients With Acute Myocardial Infarction
Kosiborod M, Inzucchi SE, Krumholz HM, Masoudi FA, Goyal A, Xiao L, Jones PG, Fiske S, Spertus JA. Glucose Normalization and Outcomes in Patients With Acute Myocardial Infarction. JAMA Internal Medicine 2009, 169: 438-446. PMID: 19273773, DOI: 10.1001/archinternmed.2008.593.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionInsulin therapyMyocardial infarctionGlucose levelsGlucose normalizationBetter survivalElevated blood glucose levelsMultivariable logistic regression modelPropensity-matched analysisMean glucose levelBlood glucose levelsPropensity-matching methodsLow glucose levelsLogistic regression modelsHospital mortalityMultivariable adjustmentImproved survivalHyperglycemic patientsSpontaneous resolutionPatientsMortality rateUS hospitalsAdmissionInfarctionTherapy
2003
Body composition and metabolic factors in obese children and adolescents
Tershakovec AM, Kuppler KM, Zemel BS, Katz L, Weinzimer S, Harty MP, Stallings VA. Body composition and metabolic factors in obese children and adolescents. International Journal Of Obesity 2003, 27: 19-24. PMID: 12532149, DOI: 10.1038/sj.ijo.0802185.Peer-Reviewed Original ResearchConceptsVisceral abdominal fatSubcutaneous abdominal fatLeptin levelsInsulin levelsFat massObese childrenAbdominal fatBody compositionHOMA-IRInsulin resistanceMetabolic factorsTotal body fat massDual-energy X-ray absorptiometryEnergy X-ray absorptiometryHigher HOMA-IRHomeostasis model assessmentNon-obese childrenHigher insulin levelsBody fat massTotal body fatGroup differencesRegional fat distributionCross-sectional assessmentX-ray absorptiometryLow glucose levels
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