2024
Multiplexable and Scalable Aqueous Synthesis Platform for Oleate‐Based, Bilayer‐Coated Gold Nanoparticles
Backhaus A, Albrecht J, Alzhanova G, Long A, Arnold W, Lee J, Tse H, Su T, Cruz‐Gomez S, Lee S, Menges F, Parent L, Ratjen L, Burtness B, Fortner J, Zimmerman J. Multiplexable and Scalable Aqueous Synthesis Platform for Oleate‐Based, Bilayer‐Coated Gold Nanoparticles. Small 2024, 20: e2309919. PMID: 38377304, DOI: 10.1002/smll.202309919.Peer-Reviewed Original ResearchGold nanoparticlesReaction scale-upLigand exchangeSpectroscopic investigationsSelf-AssemblyGram levelReaction efficiencyCapping agentSodium oleateSynthesis platformPreparation procedureGold-based nanomaterialsPhysiological pHReactionNanoparticlesSynthesis limitationsSynthesisGrowth processControl resultsParticle concentrationMultiplexingSize precisionConventional thermocyclerScale-upGold
2017
Doxorubicin-Conjugated Bimetallic Silver–Gadolinium Nanoalloy for Multimodal MRI-CT-Optical Imaging and pH-Responsive Drug Release
Mishra S, Kannan S. Doxorubicin-Conjugated Bimetallic Silver–Gadolinium Nanoalloy for Multimodal MRI-CT-Optical Imaging and pH-Responsive Drug Release. ACS Biomaterials Science & Engineering 2017, 3: 3607-3619. PMID: 33445395, DOI: 10.1021/acsbiomaterials.7b00498.Peer-Reviewed Original ResearchBimetallic nanoparticlesMicrowave-assisted polyol synthesisPH-sensitive hydrazone linkageDrug releaseResponsive drug releaseNegligible drug releaseOne-pot synthesisBimetallic silverCancer theranosisContrast abilityCapping agentPolyol synthesisAverage sizeHydrazone linkagePotential anticancer drugsAcidic mediumContrast performanceOptical imagingParamagnetic behaviorPhysiological pHMolar ratioChitosanAnticancer drugsAgDOX
2011
Characterization of Short-Lived Electrophilic Metabolites of the Anticancer Agent Laromustine (VNP40101M)
Nassar A, King I, Du J. Characterization of Short-Lived Electrophilic Metabolites of the Anticancer Agent Laromustine (VNP40101M). Chemical Research In Toxicology 2011, 24: 568-578. PMID: 21361357, DOI: 10.1021/tx100453t.Peer-Reviewed Original ResearchConceptsHuman liver microsomesNuclear magnetic resonance spectroscopyPhase II conjugatesN-acetylecysteinePooled human liver microsomesFragment ionsLiver microsomesPhase 1 metabolismCofactor nicotinamide adenine dinucleotide phosphateReactive intermediatesMoietyElectrophilic metabolitesMagnetic resonance spectroscopyM-4MethylformamidePhysiological pHVNP40101MResonance spectroscopyLaromustineConjugateActive moietyRearrangementAlkylating agentsH-DCysteine
2009
Translocating cell‐impermeable molecules through the plasma membrane of cancer cells
THEVENIN D, An M, Andreev O, Reshetnyak Y, Engelman D. Translocating cell‐impermeable molecules through the plasma membrane of cancer cells. The FASEB Journal 2009, 23: 796.7-796.7. DOI: 10.1096/fasebj.23.1_supplement.796.7.Peer-Reviewed Original ResearchCell-impermeable moleculesCell-impermeable cargo moleculesDrug designLipid bilayersHost-guest modelMembrane-impermeable cargoNovel delivery systemPhysiological pHTraverse membranesModel cargoCancer cell membraneDelivery systemCargo moleculesMoleculesCargo propertiesBilayersPeptidesMembraneSingle amino acidPropertiesC-terminusAmino acidsPotential therapeutic agentTherapeutic agentsAcidity
1982
Coupling of transmembrane proton gradients to platelet serotonin transport.
Keyes S, Rudnick G. Coupling of transmembrane proton gradients to platelet serotonin transport. Journal Of Biological Chemistry 1982, 257: 1172-1176. PMID: 7056713, DOI: 10.1016/s0021-9258(19)68170-6.Peer-Reviewed Original ResearchConceptsPlasma membrane vesiclesSerotonin transportTransmembrane proton gradientPlatelet plasma membraneTransmembrane ion gradientsApparent competitionPlasma membraneMembrane vesiclesProton gradientIon gradientsSerotonin accumulationSole driving forceVesiclesAccumulationSerotonin transporterPH differencePhysiological pHTransportersTransportPH stimulationMembraneGradient
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