2025
The etiology and prevention of early‐stage tau pathology in higher cortical circuits: Insights from aging rhesus macaques
Datta D, Arnsten A. The etiology and prevention of early‐stage tau pathology in higher cortical circuits: Insights from aging rhesus macaques. Alzheimer's & Dementia 2025, 21: e14477. PMID: 39776253, PMCID: PMC11848412, DOI: 10.1002/alz.14477.Peer-Reviewed Original ResearchConceptsAged macaquesAged rhesus macaquesP-tauTau hyperphosphorylationCortical circuitsAmyloid-beta generationSoluble phosphorylated tauCognitive deficitsAged monkeysSoluble hyperphosphorylated tauSporadic Alzheimer's diseaseAssociation cortexEarly-stage pathologyRhesus macaquesIncreased ABCalcium dysregulationCalcium regulationToxic to neuronsHyperphosphorylated tauAmyloid-betaCortexInflammatory signalingP-tau217 levelsTau pathologyPhosphorylated tau
2023
Correlations between APOE4 status and regional amyloid and tau burdens in cognitively normal older individuals
Hong Y, Kim C, Lee J, Sepulcre J. Correlations between APOE4 status and regional amyloid and tau burdens in cognitively normal older individuals. Alzheimer's & Dementia 2023, 19 DOI: 10.1002/alz.065023.Peer-Reviewed Original ResearchApolipoprotein epsilon 4Standardized uptake value ratioCarrier statusCortical thicknessPositron emission tomographyApolipoprotein epsilon 4 statusTau burdenCognitively normal older individualsAPOE4 carriersRegional amyloidNon-carriersCross-sectional studyNormal older individualsCognitively normal participantsFlorbetapir positron emission tomographyNormal cognitive functionAPOE4 non-carriersAssociated with amyloid depositionRegional tau burdenCognitive functionAD-related biomarkersAge differencesPhosphorylated tauNormal participantsClinical characteristics
2022
Diagnostic and Prognostic Performance of the Modified Lumipulse pTau 181 Assay in Plasma for Alzheimer’s Disease
Wilson E, Young C, Benitez J, Vandijck M, Swarovski M, Shahid M, Corso N, Kennedy G, Trelle A, Channappa D, Belnap M, Lind B, Le Bastard N, Quinn J, Nairn A, Kerchner G, Sha S, Wagner A, Henderson V, Longo F, Wyss‐Coray T, Poston K, Mormino E, Andreasson K. Diagnostic and Prognostic Performance of the Modified Lumipulse pTau 181 Assay in Plasma for Alzheimer’s Disease. Alzheimer's & Dementia 2022, 18 DOI: 10.1002/alz.060879.Peer-Reviewed Original ResearchAlzheimer's Disease Research CenterPtau-181Disease Research CenterAlzheimer's diseaseCohort 1Positron emission tomographyCohort 2Prognostic performanceAntibody combinationsAD participantsAβ42/Aβ40 ratioPreclinical Alzheimer's diseaseClinical AD diagnosisPlasma p-tau181Longitudinal cognitive declineTau pathologyAD pathologyCSF biomarkersTau-PETP-tau181Outcome measuresPhosphorylated tauPET biomarkersAβ40 ratioCognitive decline
2020
Fyn kinase inhibition reduces protein aggregation, increases synapse density and improves memory in transgenic and traumatic Tauopathy
Tang SJ, Fesharaki-Zadeh A, Takahashi H, Nies SH, Smith LM, Luo A, Chyung A, Chiasseu M, Strittmatter SM. Fyn kinase inhibition reduces protein aggregation, increases synapse density and improves memory in transgenic and traumatic Tauopathy. Acta Neuropathologica Communications 2020, 8: 96. PMID: 32611392, PMCID: PMC7329553, DOI: 10.1186/s40478-020-00976-9.Peer-Reviewed Original ResearchConceptsRepetitive closed head injuriesMemory deficitsPhospho-tau accumulationChronic variable stressPersistent memory deficitsP301S transgenic miceClosed head injuryFyn inhibitionPassive avoidance learningFyn kinaseGlial activationPhospho-tauPresynaptic markersSynapse lossTau accumulationHead injurySynapse densityPhosphorylated tauTherapeutic benefitTransgenic miceBehavioral improvementTrauma modelTauopathiesSpatial memoryAvoidance learning
2019
Alzheimer’s-like pathology in aging rhesus macaques: Unique opportunity to study the etiology and treatment of Alzheimer’s disease
Arnsten AFT, Datta D, Leslie S, Yang ST, Wang M, Nairn AC. Alzheimer’s-like pathology in aging rhesus macaques: Unique opportunity to study the etiology and treatment of Alzheimer’s disease. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 26230-26238. PMID: 31871209, PMCID: PMC6936707, DOI: 10.1073/pnas.1903671116.Peer-Reviewed Original ResearchTau pathologyAlzheimer's diseaseAssociation cortexTau phosphorylationMouse modelRhesus monkeysSignificant amyloid pathologyAlzheimer-like pathologyPrefrontal association cortexTau phosphorylation statePrimary sensory cortexOnset Alzheimer's diseasePrecursor protein cleavagePreventive therapyAmyloid pathologyCalcium dysregulationEarly stage degenerationPhosphorylated tauPrecipitating factorsSensory cortexCognitive deficitsAD researchRhesus macaquesPathologyCortexChronic Traumatic Encephalopathy: A Brief Overview
Fesharaki-Zadeh A. Chronic Traumatic Encephalopathy: A Brief Overview. Frontiers In Neurology 2019, 10: 713. PMID: 31333567, PMCID: PMC6616127, DOI: 10.3389/fneur.2019.00713.Peer-Reviewed Original ResearchChronic traumatic encephalopathyTraumatic brain injuryRepetitive mild traumatic brain injuryPost-traumatic brain injuryMild traumatic brain injuryPeri-vascular regionsRisk factor genesAmerican football playersTraumatic encephalopathyAPOE4 carriersSubtle presentationBrain injuryTBI treatmentTeam physiciansNeuropathological signatureNeuropsychiatric assessmentPhosphorylated tauCognitive impairmentCombat settingNeurodegenerative diseasesDiseaseMilitary veteransDistinct phenotypesSubtypesFootball players
2014
cAMP-PKA phosphorylation of tau confers risk for degeneration in aging association cortex
Carlyle BC, Nairn AC, Wang M, Yang Y, Jin LE, Simen AA, Ramos BP, Bordner KA, Craft GE, Davies P, Pletikos M, Šestan N, Arnsten AF, Paspalas CD. cAMP-PKA phosphorylation of tau confers risk for degeneration in aging association cortex. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: 5036-5041. PMID: 24707050, PMCID: PMC3977284, DOI: 10.1073/pnas.1322360111.Peer-Reviewed Original ResearchConceptsNeurofibrillary tanglesAssociation cortexAlzheimer's diseaseSpine apparatusPhosphorylated tauPattern of neurodegenerationLate-stage diseaseHigh-risk factorsNormal aged miceGenetic rodent modelsPrefrontal association cortexPrimary sensory cortexPrimary visual cortexAge-related increasePyramidal neuronsCorticocortical connectionsAged miceRisk factorsGlutamate synapsesSpine synapsesSelective vulnerabilityRodent modelsDendritic spinesSensory cortexProtein kinase phosphorylation
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