2021
Two mechanisms drive pronuclear migration in mouse zygotes
Scheffler K, Uraji J, Jentoft I, Cavazza T, Mönnich E, Mogessie B, Schuh M. Two mechanisms drive pronuclear migration in mouse zygotes. Nature Communications 2021, 12: 841. PMID: 33547291, PMCID: PMC7864974, DOI: 10.1038/s41467-021-21020-x.Peer-Reviewed Original ResearchMeSH KeywordsActinsAnimalsCell NucleusFemaleFertilizationForminsGene Expression Regulation, DevelopmentalGenes, ReporterGreen Fluorescent ProteinsLuminescent ProteinsMaleMiceMice, Inbred C57BLMice, Inbred CBAMicrofilament ProteinsMicrotubulesMovementNerve Tissue ProteinsOocytesrab GTP-Binding ProteinsRed Fluorescent ProteinSpermatozoaZygoteConceptsFertilization coneDynein-dependent mannerNetwork of microtubulesFormin 2Fertilized mouse eggsParental genomesPaternal chromosomesParental chromosomesPronuclear migrationParental pronucleiMouse eggsMale pronucleusMouse zygotesFemale pronucleusChromosomePronucleusActinFertilized eggsPronucleiCell centreZygotes
1999
Paternal Deletion from Snrpn to Ube3a in the Mouse Causes Hypotonia, Growth Retardation and Partial Lethality and Provides Evidence for a Gene Contributing to Prader-Willi Syndrome
Tsai T, Jiang Y, Bressler J, Armstrong D, Beaudet A. Paternal Deletion from Snrpn to Ube3a in the Mouse Causes Hypotonia, Growth Retardation and Partial Lethality and Provides Evidence for a Gene Contributing to Prader-Willi Syndrome. Human Molecular Genetics 1999, 8: 1357-1364. PMID: 10400982, DOI: 10.1093/hmg/8.8.1357.Peer-Reviewed Original ResearchMeSH KeywordsAbnormalities, MultipleAnimalsAutoantigensBrainChromosome DeletionFemaleGene ExpressionGenomic ImprintingHumansLigasesMaleMiceMice, Inbred StrainsMuscle HypotoniaMutagenesis, Site-DirectedOpen Reading FramesPedigreePhenotypePrader-Willi SyndromeRibonucleoproteins, Small NuclearRNAsnRNP Core ProteinsUbiquitin-Protein LigasesConceptsOpen reading framePartial lethalityExon 2Pathogenesis of PWSUpstream open reading framesObvious phenotypic abnormalitiesMouse chromosome 7CGenomic imprintsImprinted expressionPrader-Willi syndromeHuman translocationImprinted genesGene ContributingStructural genePaternal deficiencyChromosome 7CPaternal chromosomesGenotype/phenotype correlationHuman chromosomesMethylation patternsImprinting mutationsReading frameMultiple genesLoss of expressionSNRPN
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