2024
Calcium supplementation attenuates fluoride-induced bone injury via PINK1/Parkin-mediated mitophagy and mitochondrial apoptosis in mice
Hu Y, Li Y, Li M, Zhao T, Zhang W, Wang Y, He Y, Zhao H, Li H, Wang T, Zhao Y, Wang J, Wang J. Calcium supplementation attenuates fluoride-induced bone injury via PINK1/Parkin-mediated mitophagy and mitochondrial apoptosis in mice. Journal Of Hazardous Materials 2024, 465: 133411. PMID: 38181596, DOI: 10.1016/j.jhazmat.2023.133411.Peer-Reviewed Original ResearchCalcium supplementationBone injuryBone damageFluoride-exposed miceParkin knockout miceSkeletal fluorosisMitochondrial apoptosisImpairment of mitochondriaTherapy of animalsBone disordersMouse modelFluoride exposureKnockout micePINK1/Parkin-mediated mitophagyNovel targetInjuryBone trabeculaeMiceParkin-mediated mitophagyPrecise mechanismProvide protectionApoptosisExcessive consumptionSupplementationPINK1/Parkin pathway
2012
Parkin controls dopamine utilization in human midbrain dopaminergic neurons derived from induced pluripotent stem cells
Jiang H, Ren Y, Yuen E, Zhong P, Ghaedi M, Hu Z, Azabdaftari G, Nakaso K, Yan Z, Feng J. Parkin controls dopamine utilization in human midbrain dopaminergic neurons derived from induced pluripotent stem cells. Nature Communications 2012, 3: 668. PMID: 22314364, PMCID: PMC3498452, DOI: 10.1038/ncomms1669.Peer-Reviewed Original ResearchConceptsMidbrain DA neuronsDA neuronsParkinson's diseaseDopamine utilizationDopaminergic neuronsHuman midbrain dopaminergic neuronsSpontaneous DA releaseNigral DA neuronsNigral dopaminergic neuronsDisease-modifying therapiesMidbrain dopaminergic neuronsParkin knockout miceStem cellsPluripotent stem cellsPD patientsDA releaseDA neurotransmissionDA uptakeNormal subjectsKnockout miceParkin mutationsNovel targetNeuronsOxidative stressMonoamine oxidase
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