VEGF-D, unlike VEGF-A, improves vascular integrity in the lung and exerts a protective effect during acute lung injury
Yuan Y, Sharma L, Tang W, Yoon Y, Kirk S, Birukov K, Kaminski N. VEGF-D, unlike VEGF-A, improves vascular integrity in the lung and exerts a protective effect during acute lung injury. Physiology 2025, 40: 0734. DOI: 10.1152/physiol.2025.40.s1.0734.Peer-Reviewed Original ResearchAcute lung injuryAcute respiratory distress syndromeImmune cell infiltrationVEGF-DIdiopathic pulmonary fibrosisChronic obstructive pulmonary diseaseVEGF-AVascular integrityMicrovascular nicheAnti-inflammatory propertiesLung injuryCell infiltrationTNF-aLung tissueParacrine signalingPulmonary vascular integrityBarrier functionLung injury indexLevels of pro-inflammatory markersRespiratory distress syndromeTherapeutic targetTumor necrosis factor-aEffects of VEGF-ABronchoalveolar lavage fluidImproving vascular integrity
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