Adrenomedullin Is Enriched in Human Lung Vascular Niche and Enhances Endothelial Cell Maturation in Bioengineered Lung Models
Yoon Y, Kirk S, Raredon M, Kaminski N, Niklason L, Yuan Y. Adrenomedullin Is Enriched in Human Lung Vascular Niche and Enhances Endothelial Cell Maturation in Bioengineered Lung Models. American Journal Of Respiratory And Critical Care Medicine 2025, 211: a7243-a7243. DOI: 10.1164/ajrccm.2025.211.abstracts.a7243.Peer-Reviewed Original ResearchAdrenomedullin Enhances Vascular Integrity and Endothelial Cell Maturation in Bioengineered Lung Models
YOON Y, Kirk S, Promnares K, Karki P, Birukov K, Yuan Y. Adrenomedullin Enhances Vascular Integrity and Endothelial Cell Maturation in Bioengineered Lung Models. Physiology 2025, 40: 1257. DOI: 10.1152/physiol.2025.40.s1.1257.Peer-Reviewed Original ResearchVascular barrier functionEndothelial cell maturationShear stressElectric cell impedance sensingCell maturationBarrier functionMicrovascular nicheAngiopoietin-1Single-cell RNA sequencingParacrine signalingVascular modelLung modelEndothelial cell barrier functionVascular integrityEndothelial cell markersCell barrier functionEndothelial cell integrityAdjacent cell typesAnti-inflammatory responseRNA sequencingNative vasculatureCellular phenotypesFluid flowIn vitro modelGene expression
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