2023
Recent advances in organelle-specific two-photon small-molecule fluorescent probes for bioanalysis in live tissues
Lee H, Juvekar V, Lee D, Kim H. Recent advances in organelle-specific two-photon small-molecule fluorescent probes for bioanalysis in live tissues. TrAC Trends In Analytical Chemistry 2023, 165: 117128. DOI: 10.1016/j.trac.2023.117128.Peer-Reviewed Original ResearchOrganelle dynamicsEndoplasmic reticulumCellular organellesPlasma membraneTwo-photon probeOrganellesLipid dropletsSmall-molecule fluorescent probesBiological eventsNear-infrared photonsFluorescent probeTwo-photon microscopyExcitation sourceHigh-resolution imagesGolgiLiving samplesMitochondriaReticulumLysosomesProbeLiving tissuesPhoto-physical propertiesPhotons
2022
GSK3β mediates the spatiotemporal dynamics of NLRP3 inflammasome activation
Arumugam S, Qin Y, Liang Z, Han SN, Boodapati SLT, Li J, Lu Q, Flavell RA, Mehal WZ, Ouyang X. GSK3β mediates the spatiotemporal dynamics of NLRP3 inflammasome activation. Cell Death & Differentiation 2022, 29: 2060-2069. PMID: 35477991, PMCID: PMC9525599, DOI: 10.1038/s41418-022-00997-y.Peer-Reviewed Original ResearchConceptsInflammasome assemblyGlycogen synthase kinase-3βSynthase kinase-3βOrganelle dynamicsGolgi networkSubcellular machineryGolgi apparatusInflammasome activationMechanistic basisKinase-3βMolecular determinantsSpatiotemporal dynamicsGSK3β activationMitochondriaNLRP3 oligomerizationTGNSubsequent bindingGSK3βNLRP3 inflammasome activationActivationNew avenuesAssemblyStepwise processOrganellesPhosphatidylinositolQuantitative Models of Lipid Transfer and Membrane Contact Formation
Zhang Y, Ge J, Bian X, Kumar A. Quantitative Models of Lipid Transfer and Membrane Contact Formation. Contact 2022, 5: 25152564221096024. PMID: 36120532, PMCID: PMC9481209, DOI: 10.1177/25152564221096024.Peer-Reviewed Original ResearchMembrane contact sitesLipid transfer proteinLipid transferMembrane tensionMCS formationLipid exchange mechanismsMembrane contact formationOrganelle biogenesisExtended synaptotagminsOrganelle dynamicsMembrane proteinsDifferent organellesMembrane bindingMembrane expansionContact sitesMolecular mechanismsLipid flowLipid homeostasisTransfer proteinSimple lipidsProteinMembraneDistinct compositionLipidsKey role
2020
Griscelli Syndrome Type 2 Sine Albinism: Unraveling Differential RAB27A Effector Engagement
Ohishi Y, Ammann S, Ziaee V, Strege K, Groß M, Amos C, Shahrooei M, Ashournia P, Razaghian A, Griffiths G, Ehl S, Fukuda M, Parvaneh N. Griscelli Syndrome Type 2 Sine Albinism: Unraveling Differential RAB27A Effector Engagement. Frontiers In Immunology 2020, 11: 612977. PMID: 33362801, PMCID: PMC7758216, DOI: 10.3389/fimmu.2020.612977.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAdolescentAlbinismAnimalsBinding SitesCell LineChildChild, PreschoolChlorocebus aethiopsCOS CellsFemaleHumansInfantInfant, NewbornLeukocytes, MononuclearLymphohistiocytosis, HemophagocyticMaleMembrane ProteinsMutation, MissensePiebaldismPrimary Immunodeficiency Diseasesrab GTP-Binding Proteinsrab27 GTP-Binding ProteinsConceptsGS-2Rab GTPase familyRegulates vesicular transportAnimal cell linesGTPase familyOrganelle dynamicsTissue-specific effectorsVesicular transportMissense mutationsHemophagocytic lymphohistiocytosisCellular consequencesRab27aGriscelli syndrome type 2Episodes of hemophagocytic lymphohistiocytosisMutationsBinding sitesInborn errors of immunityCell linesPartial albinismErrors of immunityHair pigmentationCytotoxic lymphocytesClinical characteristicsInborn errorsAlbinism
2017
HIDE Probes: A New Toolkit for Visualizing Organelle Dynamics, Longer and at Super-Resolution
Thompson AD, Bewersdorf J, Toomre D, Schepartz A. HIDE Probes: A New Toolkit for Visualizing Organelle Dynamics, Longer and at Super-Resolution. Biochemistry 2017, 56: 5194-5201. PMID: 28792749, PMCID: PMC5854879, DOI: 10.1021/acs.biochem.7b00545.Peer-Reviewed Original ResearchConceptsLive cellsOrganelle dynamicsDiscrete organellesMultiple organellesLive-cell nanoscopyPlasma membraneDiverse processesEndoplasmic reticulumDynamic assemblyLiving cellsDynamic reorganizationOrganellesSingle-molecule switchingMembrane probeCellsMembraneMitochondriaReticulumRegulationHigh densityProbeAssemblyNew toolkitLong time periodsDivision
2010
Regulation of mouse oocyte microtubule and organelle dynamics by PADI6 and the cytoplasmic lattices
Kan R, Yurttas P, Kim B, Jin M, Wo L, Lee B, Gosden R, Coonrod S. Regulation of mouse oocyte microtubule and organelle dynamics by PADI6 and the cytoplasmic lattices. Developmental Biology 2010, 350: 311-322. PMID: 21147087, PMCID: PMC3031771, DOI: 10.1016/j.ydbio.2010.11.033.Peer-Reviewed Original ResearchConceptsOrganelle positioningMotor proteinsCytoplasmic latticesLevels of acetylated microtubulesCargo traffickingOrganelle dynamicsOrganelle redistributionMT polymerizationGerm cellsCytoplasmic microtubulesOrganellesMicrotubulesSomatic cellsA-tubulinOocyte microtubulesPADI6ProteinOocytesMotor activityCellsTraffickingCytoplasmGerm
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