2020
Griscelli Syndrome Type 2 Sine Albinism: Unraveling Differential RAB27A Effector Engagement
Ohishi Y, Ammann S, Ziaee V, Strege K, Groß M, Amos C, Shahrooei M, Ashournia P, Razaghian A, Griffiths G, Ehl S, Fukuda M, Parvaneh N. Griscelli Syndrome Type 2 Sine Albinism: Unraveling Differential RAB27A Effector Engagement. Frontiers In Immunology 2020, 11: 612977. PMID: 33362801, PMCID: PMC7758216, DOI: 10.3389/fimmu.2020.612977.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAdolescentAlbinismAnimalsBinding SitesCell LineChildChild, PreschoolChlorocebus aethiopsCOS CellsFemaleHumansInfantInfant, NewbornLeukocytes, MononuclearLymphohistiocytosis, HemophagocyticMaleMembrane ProteinsMutation, MissensePiebaldismPrimary Immunodeficiency Diseasesrab GTP-Binding Proteinsrab27 GTP-Binding ProteinsConceptsGS-2Rab GTPase familyRegulates vesicular transportAnimal cell linesGTPase familyOrganelle dynamicsTissue-specific effectorsVesicular transportMissense mutationsHemophagocytic lymphohistiocytosisCellular consequencesRab27aGriscelli syndrome type 2Episodes of hemophagocytic lymphohistiocytosisMutationsBinding sitesInborn errors of immunityCell linesPartial albinismErrors of immunityHair pigmentationCytotoxic lymphocytesClinical characteristicsInborn errorsAlbinism
2016
Bistability in the Rac1, PAK, and RhoA Signaling Network Drives Actin Cytoskeleton Dynamics and Cell Motility Switches
Byrne KM, Monsefi N, Dawson JC, Degasperi A, Bukowski-Wills JC, Volinsky N, Dobrzyński M, Birtwistle MR, Tsyganov MA, Kiyatkin A, Kida K, Finch AJ, Carragher NO, Kolch W, Nguyen LK, von Kriegsheim A, Kholodenko BN. Bistability in the Rac1, PAK, and RhoA Signaling Network Drives Actin Cytoskeleton Dynamics and Cell Motility Switches. Cell Systems 2016, 2: 38-48. PMID: 27136688, PMCID: PMC4802415, DOI: 10.1016/j.cels.2016.01.003.Peer-Reviewed Original ResearchConceptsPAK inhibitionMesenchymal breast cancer cellsCell migrationActin cytoskeleton dynamicsRho small GTPase familyRac1 activation levelsSmall GTPase familySwitch-like responsePAK family kinasesSmall chemical inhibitorsCytoskeleton dynamicsActin dynamicsGTPase familyFamily kinasesGTPase activityBistable fashionInhibitory crosstalkChemical inhibitorsBreast cancer cellsMass spectrometry-based quantitationRac1RhoACell morphologyCancer cellsPAK
2015
The miR-199–dynamin regulatory axis controls receptor-mediated endocytosis
Aranda JF, Canfrán-Duque A, Goedeke L, Suárez Y, Fernández-Hernando C. The miR-199–dynamin regulatory axis controls receptor-mediated endocytosis. Journal Of Cell Science 2015, 128: 3197-3209. PMID: 26163491, PMCID: PMC4582188, DOI: 10.1242/jcs.165233.Peer-Reviewed Original ResearchConceptsClathrin heavy chainReceptor-mediated endocytosisIntracellular traffickingLow-density lipoprotein receptorGene expressionMiR-199aSmall non-coding RNAsNon-coding RNAsTarget gene expressionDynamin genesEukaryotic cellsHuman cell linesEndocytic transportGTPase familyCav-1 expressionUnexpected layerCaveolin-1Intronic sequencesIntracellular transportPhysiological processesEndocytosisImportant regulatorMiR-199bCell linesGenes
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