2024
Medical comorbidities and lower myelin content are associated with poor cognition in young adults with perinatally acquired HIV
Patel P, Prince D, Bolenzius J, Ch’en P, Chiarella J, Kolind S, Vavasour I, Pedersen T, Levendovszky S, Spudich S, Marra C, Paul R. Medical comorbidities and lower myelin content are associated with poor cognition in young adults with perinatally acquired HIV. AIDS 2024, 38: 1932-1939. PMID: 39110577, PMCID: PMC11524773, DOI: 10.1097/qad.0000000000003989.Peer-Reviewed Original ResearchPoor cognitionCognitive impairmentHorizontally acquired HIVMarkers of cognitive reserveAssociated with poorer cognitionRisk factorsCross-sectional studyYoung adultsLower cognitive scoresYears of educationMultiple cognitive domainsExperience cognitive deficitsCognitive domain scoresHIV-uninfected controlsOlder adultsCorticospinal tractCognitive batteryDomain scoresMedical comorbidityCognitive deficitsCognitive domainsMyelin contentCognitive reserveNeuroimaging dataCognitive scores
2018
Association of the Haptoglobin Gene Polymorphism With Cognitive Function and Decline in Elderly African American Adults With Type 2 Diabetes
Beeri M, Lin H, Sano M, Ravona-Springer R, Liu X, Bendlin B, Gleason C, Guerrero-Berroa E, Soleimani L, Launer L, Ehrenberg S, Lache O, Seligman Y, Levy A. Association of the Haptoglobin Gene Polymorphism With Cognitive Function and Decline in Elderly African American Adults With Type 2 Diabetes. JAMA Network Open 2018, 1: e184458. PMID: 30646354, PMCID: PMC6324406, DOI: 10.1001/jamanetworkopen.2018.4458.Peer-Reviewed Original ResearchConceptsMini-Mental State ExaminationMini-Mental State Examination scoreAfrican American adultsIndividuals of white race/ethnicityAfrican American individualsBaseline MMSE scoreType 2 diabetesAmerican adultsWhite race/ethnicityDementia riskHp 1-1 genotypeCognitive functionMMSE scoreAmerican individualsCognitive declineElevated dementia riskRates of type 2 diabetesAssociated with more cognitive impairmentAssociated with poorer cognitive functionHp genotypeAssociated with poorer cognitionFaster cognitive declineAfrican American participantsPoorer cognitive functionAfrican American study participants
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