2024
Acute Kidney Injury, Systemic Inflammation, and Long-Term Cognitive Function
Bhatraju P, Zelnick L, Stanaway I, Ikizler T, Menez S, Chinchilli V, Coca S, Kaufman J, Kimmel P, Parikh C, Go A, Siew E, Wurfel M, Himmelfarb J. Acute Kidney Injury, Systemic Inflammation, and Long-Term Cognitive Function. Clinical Journal Of The American Society Of Nephrology 2024, 19: 829-836. PMID: 38728094, PMCID: PMC11254015, DOI: 10.2215/cjn.0000000000000473.Peer-Reviewed Original ResearchConceptsLong-term cognitive impairmentRisk of long-term cognitive impairmentCognitive impairmentCognitive functionCognitive declineSoluble TNF receptor-1 concentrationsAssociated with poorer cognitive functionModified Mini-Mental Status ExaminationLong-term cognitive functionPoorer cognitive functionMini-Mental Status ExaminationLong-term cognitive declineSystemic inflammationCognitive testsCognitive dysfunctionSerial evaluationMediation analysisPersistent systemic inflammationSystemic inflammatory biomarkersAcute kidney injuryBaseline kidney functionComplication of CKDAssociated with long-term cognitive declineEpisode of AKITNF receptor 1
2018
Association of the Haptoglobin Gene Polymorphism With Cognitive Function and Decline in Elderly African American Adults With Type 2 Diabetes
Beeri M, Lin H, Sano M, Ravona-Springer R, Liu X, Bendlin B, Gleason C, Guerrero-Berroa E, Soleimani L, Launer L, Ehrenberg S, Lache O, Seligman Y, Levy A. Association of the Haptoglobin Gene Polymorphism With Cognitive Function and Decline in Elderly African American Adults With Type 2 Diabetes. JAMA Network Open 2018, 1: e184458. PMID: 30646354, PMCID: PMC6324406, DOI: 10.1001/jamanetworkopen.2018.4458.Peer-Reviewed Original ResearchConceptsMini-Mental State ExaminationMini-Mental State Examination scoreAfrican American adultsIndividuals of white race/ethnicityAfrican American individualsBaseline MMSE scoreType 2 diabetesAmerican adultsWhite race/ethnicityDementia riskHp 1-1 genotypeCognitive functionMMSE scoreAmerican individualsCognitive declineElevated dementia riskRates of type 2 diabetesAssociated with more cognitive impairmentAssociated with poorer cognitive functionHp genotypeAssociated with poorer cognitionFaster cognitive declineAfrican American participantsPoorer cognitive functionAfrican American study participants
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