2024
Safety, tolerability, and efficacy estimate of evoked gamma oscillation in mild to moderate Alzheimer’s disease
Hajós M, Boasso A, Hempel E, Shpokayte M, Konisky A, Seshagiri C, Fomenko V, Kwan K, Nicodemus-Johnson J, Hendrix S, Vaughan B, Kern R, Megerian J, Malchano Z. Safety, tolerability, and efficacy estimate of evoked gamma oscillation in mild to moderate Alzheimer’s disease. Frontiers In Neurology 2024, 15: 1343588. PMID: 38515445, PMCID: PMC10957179, DOI: 10.3389/fneur.2024.1343588.Peer-Reviewed Original ResearchAssessment of adverse eventsMild to moderate ADGamma oscillationsModerate ADAmyloid-related imaging abnormalitiesAlzheimer's diseaseMild-to-moderate Alzheimer's diseaseSecondary clinical outcome measuresTherapy systemPrimary outcome measureHigher adherence ratesWhole-brain volumeClinical outcome measuresSecondary outcome measuresModerate Alzheimer's diseaseDisease-modifying effectsBaseline MMSE scoreStudy discontinuationExperimental AD modelsWell-toleratedEfficacy outcomesClinical benefitAdverse eventsDaily treatmentClinical criteria
2018
Association of the Haptoglobin Gene Polymorphism With Cognitive Function and Decline in Elderly African American Adults With Type 2 Diabetes
Beeri M, Lin H, Sano M, Ravona-Springer R, Liu X, Bendlin B, Gleason C, Guerrero-Berroa E, Soleimani L, Launer L, Ehrenberg S, Lache O, Seligman Y, Levy A. Association of the Haptoglobin Gene Polymorphism With Cognitive Function and Decline in Elderly African American Adults With Type 2 Diabetes. JAMA Network Open 2018, 1: e184458. PMID: 30646354, PMCID: PMC6324406, DOI: 10.1001/jamanetworkopen.2018.4458.Peer-Reviewed Original ResearchConceptsMini-Mental State ExaminationMini-Mental State Examination scoreAfrican American adultsIndividuals of white race/ethnicityAfrican American individualsBaseline MMSE scoreType 2 diabetesAmerican adultsWhite race/ethnicityDementia riskHp 1-1 genotypeCognitive functionMMSE scoreAmerican individualsCognitive declineElevated dementia riskRates of type 2 diabetesAssociated with more cognitive impairmentAssociated with poorer cognitive functionHp genotypeAssociated with poorer cognitionFaster cognitive declineAfrican American participantsPoorer cognitive functionAfrican American study participants
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