2022
Homocysteine Levels and Clinical Outcomes in Schizophrenia—A Pilot Randomized Controlled Trial
Vedam V, Ghanta M, Kantipudi S, David D, Vijayalakshmi M, Nuthalapati P. Homocysteine Levels and Clinical Outcomes in Schizophrenia—A Pilot Randomized Controlled Trial. Journal Of Pharmacology And Pharmacotherapeutics 2022, 13: 284-292. DOI: 10.1177/0976500x221128649.Peer-Reviewed Original ResearchBrief Psychiatric Rating ScaleBrief Psychiatric Rating Scale scoresSchizophrenia patientsAbnormal Involuntary Movement Scale scorePsychiatric Rating ScaleEfficacy of olanzapineSafety of haloperidolHomocysteine levelsOlanzapine groupHaloperidol groupSchizophrenia treatmentPeripheral bloodOlanzapineRating ScalePilot randomized controlled trialHaloperidolSchizophreniaLevels of peripheral bloodTreatment outcomesScale scoreInterventional clinical trialsBlood homocysteine levelsRandomized Controlled TrialsClinical outcomesRight drug
2020
Olanzapine for the Prevention of Postdischarge Nausea and Vomiting after Ambulatory Surgery: A Randomized Controlled Trial.
Hyman JB, Park C, Lin HM, Cole B, Rosen L, Fenske SS, Barr Grzesh RL, Blank SV, Polsky SB, Hartnett M, Taub PJ, Palvia V, DeMaria S, Ascher-Walsh C. Olanzapine for the Prevention of Postdischarge Nausea and Vomiting after Ambulatory Surgery: A Randomized Controlled Trial. Anesthesiology 2020, 132: 1419-1428. PMID: 32229754, DOI: 10.1097/aln.0000000000003286.Peer-Reviewed Original ResearchConceptsOlanzapine groupPlacebo groupAmbulatory surgeryPostdischarge nauseaSevere nauseaFemale patients 50 yearsStandard antiemetic prophylaxisPlacebo-controlled studyPlacebo-controlled trialPrimary composite outcomeSingle preoperative dosePatients 50 yearsRisk of nauseaAddition of olanzapineAntiemetic prophylaxisOlanzapine 10Preoperative doseComposite outcomeSecondary outcomesControlled TrialsPrimary outcomeOral olanzapineGeneral anesthesiaNauseaVomiting
2006
Randomized, Double-Blind Trial of Olanzapine Versus Placebo in Patients Prodromally Symptomatic for Psychosis
McGlashan TH, Zipursky RB, Perkins D, Addington J, Miller T, Woods SW, Hawkins KA, Hoffman RE, Preda A, Epstein I, Addington D, Lindborg S, Trzaskoma Q, Tohen M, Breier A. Randomized, Double-Blind Trial of Olanzapine Versus Placebo in Patients Prodromally Symptomatic for Psychosis. American Journal Of Psychiatry 2006, 163: 790-799. PMID: 16648318, DOI: 10.1176/ajp.2006.163.5.790.Peer-Reviewed Original ResearchConceptsOlanzapine patientsPlacebo patientsProdromal symptomsPsychosis ratesDouble-blind treatment periodEfficacy of olanzapineFurther treatment researchOlanzapine Versus PlaceboOlanzapine-treated patientsDouble-blind trialPhase of illnessPositive prodromal symptomsInduced Weight GainHazard of conversionSignificant differencesNorth American clinicsSignificant treatment differencesOlanzapine groupVersus PlaceboPlacebo groupSymptom scoresEfficacy measuresWeek 8Treatment periodPatients
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