A Neoplastic Gene Fusion Mimics Trans-Splicing of RNAs in Normal Human Cells
Li H, Wang J, Mor G, Sklar J. A Neoplastic Gene Fusion Mimics Trans-Splicing of RNAs in Normal Human Cells. Science 2008, 321: 1357-1361. PMID: 18772439, DOI: 10.1126/science.1156725.Peer-Reviewed Original ResearchMeSH KeywordsCell HypoxiaCell LineCell Line, TumorChromosome AberrationsChromosomes, Human, Pair 17Chromosomes, Human, Pair 7Co-Repressor ProteinsDeferoxamineDNA-Binding ProteinsEndometrial NeoplasmsEndometriumExonsFemaleGene FusionHumansMenstrual CycleMutant Chimeric ProteinsNeoplasm ProteinsProgesteroneProtein BiosynthesisRNA PrecursorsRNA, MessengerStromal CellsTrans-SplicingTranscription FactorsTranslocation, GeneticConceptsGene fusionsChimeric RNAsPrecursor messenger RNAChimeric gene productsResultant chimeric transcriptsTrans splicingNormal human cellsAnti-apoptotic activityChromosome 7p15Gene productsChromosomal rearrangementsChromosome 17q11JAZF1 geneHuman cellsTumor-specific productsRNANormal endometrial stromal cellsChimeric transcriptsMessenger RNAExonsProteinHuman tumorsStromal cellsEndometrial stromal cellsCellsRegulation and activation of ezrin protein in endometriosis
Ornek T, Fadiel A, Tan O, Naftolin F, Arici A. Regulation and activation of ezrin protein in endometriosis. Human Reproduction 2008, 23: 2104-2112. PMID: 18552365, DOI: 10.1093/humrep/den215.Peer-Reviewed Original ResearchConceptsEndometrial stromal cellsEctopic endometrial tissuePathogenesis of endometriosisWestern blot analysisEndometrial tissueNormal endometriumEctopic endometrial stromal cellsNormal endometrial stromal cellsEctopic endometrial tissue samplesEndometrial tissue samplesEzrin proteinMembrane invasionBlot analysisExpression of ezrinEndometriosisStromal cellsEutopicPotential markerTissue samplesWomenInvasive characteristicsCell invasionEctopic sitesEndometriumInvasive potential
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