2013
A Chimeric RNA Characteristic of Rhabdomyosarcoma in Normal Myogenesis Process
Yuan H, Qin F, Movassagh M, Park H, Golden W, Xie Z, Zhang P, Sklar J, Li H. A Chimeric RNA Characteristic of Rhabdomyosarcoma in Normal Myogenesis Process. Cancer Discovery 2013, 3: 1394-1403. PMID: 24089019, DOI: 10.1158/2159-8290.cd-13-0186.Peer-Reviewed Original ResearchMeSH KeywordsCell DifferentiationCell LineForkhead Box Protein O1Forkhead Transcription FactorsGene Expression Regulation, DevelopmentalGene FusionHumansMesenchymal Stem CellsMuscle DevelopmentMusclesMyoD ProteinMyogeninOncogene Proteins, FusionPaired Box Transcription FactorsPAX3 Transcription FactorRhabdomyosarcoma, AlveolarTranslocation, GeneticConceptsPAX3-FOXO1Chimeric RNAsChromosomal translocationsMuscle differentiation processChimeric fusion RNAsChimeric gene productsNormal cellsNormal non-cancer cellsPluripotent cellsNormal fetal muscleNon-cancer cellsGene productsChromosomal rearrangementsPosttranscriptional mechanismsDevelopmental roleFusion RNAGene fusionsDifferentiation processRNA characteristicsSame lineageMyogenesis processChimeric productsNormal developmentRhabdomyosarcoma cellsRNA
2008
A Neoplastic Gene Fusion Mimics Trans-Splicing of RNAs in Normal Human Cells
Li H, Wang J, Mor G, Sklar J. A Neoplastic Gene Fusion Mimics Trans-Splicing of RNAs in Normal Human Cells. Science 2008, 321: 1357-1361. PMID: 18772439, DOI: 10.1126/science.1156725.Peer-Reviewed Original ResearchMeSH KeywordsCell HypoxiaCell LineCell Line, TumorChromosome AberrationsChromosomes, Human, Pair 17Chromosomes, Human, Pair 7Co-Repressor ProteinsDeferoxamineDNA-Binding ProteinsEndometrial NeoplasmsEndometriumExonsFemaleGene FusionHumansMenstrual CycleMutant Chimeric ProteinsNeoplasm ProteinsProgesteroneProtein BiosynthesisRNA PrecursorsRNA, MessengerStromal CellsTrans-SplicingTranscription FactorsTranslocation, GeneticConceptsGene fusionsChimeric RNAsPrecursor messenger RNAChimeric gene productsResultant chimeric transcriptsTrans splicingNormal human cellsAnti-apoptotic activityChromosome 7p15Gene productsChromosomal rearrangementsChromosome 17q11JAZF1 geneHuman cellsTumor-specific productsRNANormal endometrial stromal cellsChimeric transcriptsMessenger RNAExonsProteinHuman tumorsStromal cellsEndometrial stromal cellsCells
1998
Detection of the SYT-SSX chimeric RNA of synovial sarcoma in paraffin-embedded tissue and its application in problematic cases.
Argani P, Zakowski M, Klimstra D, Rosai J, Ladanyi M. Detection of the SYT-SSX chimeric RNA of synovial sarcoma in paraffin-embedded tissue and its application in problematic cases. Modern Pathology 1998, 11: 65-71. PMID: 9556426.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedChromosomes, Human, Pair 18Diagnosis, DifferentialFemaleHead and Neck NeoplasmsHumansImmunohistochemistryKeratinsMaleMolecular Probe TechniquesNeoplasm ProteinsParaffin EmbeddingPolymerase Chain ReactionProteinsProto-Oncogene ProteinsRecombinant Fusion ProteinsRepressor ProteinsRNA, NeoplasmSarcoma, SynovialSkin NeoplasmsThoracic NeoplasmsTranscription, GeneticTranslocation, GeneticX ChromosomeConceptsSynovial sarcomaMalignant solitary fibrous tumorSkin adnexal tumorsThymus-like differentiationSpindle epithelial tumorSolitary fibrous tumorSpindle cell tumorsSYT-SSXReverse-transcriptase polymerase chain reaction assayParaffin-embedded tissuesPolymerase chain reaction assayAdnexal tumorsFibrous tumorEpithelial tumorsCell tumorsChimeric RNAsRNA transcriptsTarget sequenceTumorThoracic regionSarcomaSubcutaneous tissue
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