2018
Allatostatin C modulates nociception and immunity in Drosophila
Bachtel ND, Hovsepian GA, Nixon DF, Eleftherianos I. Allatostatin C modulates nociception and immunity in Drosophila. Scientific Reports 2018, 8: 7501. PMID: 29760446, PMCID: PMC5951828, DOI: 10.1038/s41598-018-25855-1.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntimicrobial Cationic PeptidesBacterial InfectionsBlood ProteinsDisease Models, AnimalDrosophila melanogasterDrosophila ProteinsFemaleGene Knockdown TechniquesHot TemperatureHyperalgesiaImmunityIon ChannelsMutationNeuropeptidesNociceptionPhotorhabdusReceptors, G-Protein-CoupledUp-RegulationConceptsReceptor 2Bacterial infectionsHost survivalAbsence of infectionLigand-gated ion channelsInflammatory painNociceptive neuronsChronic inflammationImmune infiltrationInflammatory responseAlters immunityImmunosuppressive substancesThermal nociceptionPathogenic bacterial infectionsNeuronal roleNociceptionRobust upregulationAllatostatin receptorImmune deficiency (IMD) pathwayBacterial challengeInfectionMicrobial stimulationImmune signalingHomeostatic conditionsDirect activationCurcumin Acts as a Positive Allosteric Modulator of α 7-Nicotinic Acetylcholine Receptors and Reverses Nociception in Mouse Models of Inflammatory Pain
El Nebrisi E, Bagdas D, Toma W, Al Samri H, Brodzik A, Alkhlaif Y, Yang K, Howarth F, Damaj I, Oz M. Curcumin Acts as a Positive Allosteric Modulator of α 7-Nicotinic Acetylcholine Receptors and Reverses Nociception in Mouse Models of Inflammatory Pain. Journal Of Pharmacology And Experimental Therapeutics 2018, 365: 190-200. PMID: 29339457, PMCID: PMC7947331, DOI: 10.1124/jpet.117.245068.Peer-Reviewed Original ResearchConceptsEffect of curcuminPositive allosteric modulatorsMouse modelVisceral painAntinociceptive effectNACh receptorsAcetylcholine receptorsAllosteric modulatorsΑ7 nicotinic acetylcholine receptorVisceral pain modelHuman nicotinic acetylcholine receptorNicotinic acetylcholine receptorsInflammatory painPain modelNociceptive behaviorReceptor agonistSignificant potentiationDependent ClLocomotor activityACh concentrationPainNociceptionReceptorsTonicG proteins
2017
FGF13 Selectively Regulates Heat Nociception by Interacting with Nav1.7
Yang L, Dong F, Yang Q, Yang P, Wu R, Wu Q, Wu D, Li C, Zhong Y, Lu Y, Cheng X, Xu F, Chen L, Bao L, Zhang X. FGF13 Selectively Regulates Heat Nociception by Interacting with Nav1.7. Neuron 2017, 93: 806-821.e9. PMID: 28162808, DOI: 10.1016/j.neuron.2017.01.009.Peer-Reviewed Original ResearchConceptsDorsal root gangliaAction potential firingHeat nociceptionFibroblast growth factorDRG neuronsSustained action potential firingTransient receptor potential cation channel V1Intracellular fibroblast growth factorsNoxious heat stimulationNoxious heat stimuliMouse DRG neuronsNociceptive neuronsNociceptive behaviorSodium channel NaRoot gangliaHeat stimuliNociceptionAction potentialsSodium currentHeat stimulationGrowth factorFGF13NeuronsChannel NaCurrent knowledge
2010
Effect of capsaicin on potassium conductance and electromotility of the guinea pig outer hair cell
Wu T, Song L, Shi X, Jiang Z, Santos-Sacchi J, Nuttall A. Effect of capsaicin on potassium conductance and electromotility of the guinea pig outer hair cell. Hearing Research 2010, 272: 117-124. PMID: 21044673, PMCID: PMC3387680, DOI: 10.1016/j.heares.2010.10.010.Peer-Reviewed Original ResearchConceptsOuter hair cellsTRPV-1 channelsHair cellsPrimary sensory neuronsEffects of capsaicinGuinea pig outer hair cellsSensory neuronsPharmacological actionsCapsaicinPotassium conductancePotent blockerPharmacological propertiesDirect actionNovel actionCochlear amplificationK conductanceAuditory effectsClassic activatorAuditory receptionCellsNociceptionElectromotilityBlockersNew findingsNeurons
1990
Kynurenic acid blocks chemogenic nociception
Hajós M, Engberg G. Kynurenic acid blocks chemogenic nociception. Journal Of Pharmacy And Pharmacology 1990, 42: 373-374. PMID: 1976793, DOI: 10.1111/j.2042-7158.1990.tb05434.x.Peer-Reviewed Original Research
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