2020
Guanylate-binding proteins convert cytosolic bacteria into caspase-4 signaling platforms
Wandel MP, Kim BH, Park ES, Boyle KB, Nayak K, Lagrange B, Herod A, Henry T, Zilbauer M, Rohde J, MacMicking JD, Randow F. Guanylate-binding proteins convert cytosolic bacteria into caspase-4 signaling platforms. Nature Immunology 2020, 21: 880-891. PMID: 32541830, PMCID: PMC7381384, DOI: 10.1038/s41590-020-0697-2.Peer-Reviewed Original ResearchConceptsGuanylate-binding proteinsCaspase-4 activationCaspase-4Human caspase-4Pyroptotic cell deathGram-negative bacteriaCytosolic bacteriaReplicative nicheEvolutionary evidenceIntracellular bacteriaCell deathMultiple antagonistsNeighboring cellsCaspase-11BacteriaAntibacterial defenseBacterial challengeGasderminShigella flexneriProteinDependent pyroptosisActivationPathwayBacterial lipopolysaccharideGBP2
2018
Allatostatin C modulates nociception and immunity in Drosophila
Bachtel ND, Hovsepian GA, Nixon DF, Eleftherianos I. Allatostatin C modulates nociception and immunity in Drosophila. Scientific Reports 2018, 8: 7501. PMID: 29760446, PMCID: PMC5951828, DOI: 10.1038/s41598-018-25855-1.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntimicrobial Cationic PeptidesBacterial InfectionsBlood ProteinsDisease Models, AnimalDrosophila melanogasterDrosophila ProteinsFemaleGene Knockdown TechniquesHot TemperatureHyperalgesiaImmunityIon ChannelsMutationNeuropeptidesNociceptionPhotorhabdusReceptors, G-Protein-CoupledUp-RegulationConceptsReceptor 2Bacterial infectionsHost survivalAbsence of infectionLigand-gated ion channelsInflammatory painNociceptive neuronsChronic inflammationImmune infiltrationInflammatory responseAlters immunityImmunosuppressive substancesThermal nociceptionPathogenic bacterial infectionsNeuronal roleNociceptionRobust upregulationAllatostatin receptorImmune deficiency (IMD) pathwayBacterial challengeInfectionMicrobial stimulationImmune signalingHomeostatic conditionsDirect activation
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