IDHwt glioblastomas can be stratified by their transcriptional response to standard treatment, with implications for targeted therapy
Tanner G, Barrow R, Ajaib S, Al-Jabri M, Ahmed N, Pollock S, Finetti M, Rippaus N, Bruns A, Syed K, Poulter J, Matthews L, Hughes T, Wilson E, Johnson C, Varn F, Brüning-Richardson A, Hogg C, Droop A, Gusnanto A, Care M, Cutillo L, Westhead D, Short S, Jenkinson M, Brodbelt A, Chakrabarty A, Ismail A, Verhaak R, Stead L. IDHwt glioblastomas can be stratified by their transcriptional response to standard treatment, with implications for targeted therapy. Genome Biology 2024, 25: 45. PMID: 38326875, PMCID: PMC10848526, DOI: 10.1186/s13059-024-03172-3.Peer-Reviewed Original ResearchConceptsGBM tumorsTumor microenvironmentNeoplastic cellsResponse to standard treatmentTreatment resistance mechanismsDifferentiated neoplastic cellsSurrounding normal brainResponder subtypesGBM stem cellsAssociated with distinct changesRecurrent tumorsIDHwt glioblastomasTargeted therapyIDH1 mutationStandard treatmentBrain neoplasmsTumorCancer-cellBrain tumorsEffective treatmentNeurotransmitter signalingStem cellsMesenchymal transitionPairs of pre-Subtypes
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