2002
Neuroprotective role of δ-opioid receptors in cortical neurons
Zhang J, Gibney GT, Zhao P, Xia Y. Neuroprotective role of δ-opioid receptors in cortical neurons. American Journal Of Physiology - Cell Physiology 2002, 282: c1225-c1234. PMID: 11997236, DOI: 10.1152/ajpcell.00226.2001.Peer-Reviewed Original ResearchConceptsCortical neuronsNeuronal injuryHypoxic injuryReceptor activationKappa-opioid receptor inhibitionDelta-opioid receptor activationOpioid receptor activationCultured cortical neuronsGlutamate-induced injuryΔ-opioid receptorsLactate dehydrogenase releaseImmature neuronsNeuroprotective roleReceptor inhibitionHypoxic exposureNeuronal susceptibilityCell injuryDay 4InjuryDehydrogenase releaseNeuronsActivation/inhibitionHypoxiaHypoxic conditionsHypoxic stress
1998
NEURONAL INJURY ASSOCIATED WITH HIV-1: Approaches to Treatment
Lipton S. NEURONAL INJURY ASSOCIATED WITH HIV-1: Approaches to Treatment. The Annual Review Of Pharmacology And Toxicology 1998, 38: 159-177. PMID: 9597152, DOI: 10.1146/annurev.pharmtox.38.1.159.Peer-Reviewed Original ResearchConceptsNeuronal injuryNeuronal damageHIV-1-associated cognitive/motor complexN-methyl-D-aspartate (NMDA) receptor-operated channelsCognitive/motor complexAIDS dementia complexHIV-1 resultsHIV-1 infectionExistence of HIVBrains of patientsReceptor-operated channelsFuture pharmacological interventionsFinal common pathwayPlatelet-activating factorFree radicalsAIDS dementiaReactive astrocytesDementia complexCognitive dysfunctionNMDA antagonistsExcessive activationNeuronal susceptibilityPharmacological interventionsHIV-1Excessive influx
1994
HIV-related neuronal injury
Lipton S. HIV-related neuronal injury. Molecular Neurobiology 1994, 8: 181-196. PMID: 7999315, DOI: 10.1007/bf02780669.Peer-Reviewed Original ResearchConceptsArachidonic acidExistence of HIVCalcium channel antagonistsVoltage-dependent Ca2Receptor-operated channelsFuture pharmacological interventionsFinal common pathwayAmyotrophic lateral sclerosisPlatelet-activating factorDysfunction of cognitionDemise of neuronsNeuropathic painAdult patientsAIDS dementiaNeuronal injuryNeurological manifestationsNeuronal damageImmunodeficiency syndromeAIDS patientsChannel antagonistsNMDA antagonistsNeuronal susceptibilityPharmacological interventionsLateral sclerosisParkinson's diseaseCa2+, N-Methyl-d-Aspartate Receptors, and Aids-Related Neuronal Injury
Lipton S. Ca2+, N-Methyl-d-Aspartate Receptors, and Aids-Related Neuronal Injury. International Review Of Neurobiology 1994, 36: 1-27. PMID: 7822116, DOI: 10.1016/s0074-7742(08)60301-3.Peer-Reviewed Original ResearchConceptsN-methyl-D-aspartate (NMDA) receptor-operated channelsN-methyl-D-aspartate receptorsHIV-1 envelope protein gp120Existence of HIVVoltage-dependent Ca2Receptor-operated channelsFuture pharmacological interventionsFinal common pathwayAmyotrophic lateral sclerosisEnvelope protein gp120Demise of neuronsNeuronal injuryAIDS patientsNeuronal susceptibilityPharmacological interventionsProtein gp120Lateral sclerosisParkinson's diseaseMacrophage productionInduces releaseHIVNitric oxideNeurodegenerative diseasesDiseaseHuntington's disease
1992
Models of neuronal injury in AIDS: another role for the NMDA receptor?
Lipton S. Models of neuronal injury in AIDS: another role for the NMDA receptor? Trends In Neurosciences 1992, 15: 75-79. PMID: 1373919, DOI: 10.1016/0166-2236(92)90013-x.Peer-Reviewed Original ResearchConceptsNMDA receptor-operated channelsExistence of HIVVoltage-dependent Ca2Receptor-operated channelsFuture pharmacological interventionsFinal common pathwayDysfunction of cognitionDemise of neuronsNeuronal injuryNeurological manifestationsNeuronal damageImmunodeficiency syndromeAIDS patientsNMDA receptorsNeuronal susceptibilityPharmacological interventionsType 1 resultsCommon pathwayNeuronsPatientsInjuryTwo-thirdsHIVDysfunctionEpilepsy
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