2024
Current state and potential applications of neonatal Fc receptor (FcRn) inhibitors in hematologic conditions
Jacobs J, Booth G, Raza S, Clark L, Fasano R, Gavriilaki E, Abels E, Binns T, Duque M, McQuilten Z, Mingot‐Castellano M, Savani B, Sharma D, Tran M, Tormey C, Moise K, Bloch E, Adkins B. Current state and potential applications of neonatal Fc receptor (FcRn) inhibitors in hematologic conditions. American Journal Of Hematology 2024, 99: 2351-2366. PMID: 39324647, PMCID: PMC11560617, DOI: 10.1002/ajh.27487.Peer-Reviewed Original ResearchHematological conditionsFcRn inhibitorsClinical trialsStandardized treatment algorithmClinical trial dataNeonatal Fc receptorIn vivo studiesImmune-mediatedHematological disordersTreatment algorithmTransports IgGAdverse eventsImmunomodulatory/immunosuppressive therapiesIgG levelsPatient populationProtective IgGFc receptorsTherapeutic strategiesMucosal surfacesRheumatologic conditionsIgG antibodiesImmunoglobulin isotypesTrial dataIgGFcRn
2022
Serum Autoantibody Lowering by the Anti-FcRn Monoclonal Antibody, Nipocalimab, Correlates With Clinical Improvement in Generalized Myasthenia Gravis Patients
Ramchandren S, Guptill J, Antozzi C, Bril V, Gamez J, Meuth S, Nowak R, Quan D, Mantecon M, Ling L, Zhu Y, Karcher K, Sun H. Serum Autoantibody Lowering by the Anti-FcRn Monoclonal Antibody, Nipocalimab, Correlates With Clinical Improvement in Generalized Myasthenia Gravis Patients. Neurology 2022, 99: s35-s37. DOI: 10.1212/01.wnl.0000903304.73134.e3.Peer-Reviewed Original ResearchPhase 2 studyMyasthenia gravis patientsClinical improvementGravis patientsMonoclonal antibodiesAnti-AChR autoantibodiesMuSK-positive patientsMyasthenia Gravis ActivitiesDaily living scoreSerum total IgGSerum IgG levelsMG-ADL scoreNeonatal Fc receptorGMG patientsClinical responseDose armLiving scorePathogenic autoantibodiesPositive patientsIgG levelsPathogenic antibodiesIgG autoantibodiesPharmacodynamic effectsSerum IgGTotal IgG
2021
Targeting the neonatal Fc receptor in pemphigus: safety first
Micevic G, Lo SN, Rajan N. Targeting the neonatal Fc receptor in pemphigus: safety first. British Journal Of Dermatology 2021, 186: 389-390. PMID: 34961930, PMCID: PMC9295899, DOI: 10.1111/bjd.20939.Peer-Reviewed Original Research
2009
Renal FcRn Reclaims Albumin but Facilitates Elimination of IgG
Sarav M, Wang Y, Hack B, Chang A, Jensen M, Bao L, Quigg R. Renal FcRn Reclaims Albumin but Facilitates Elimination of IgG. Journal Of The American Society Of Nephrology 2009, 20: 1941-1952. PMID: 19661163, PMCID: PMC2736763, DOI: 10.1681/asn.2008090976.Peer-Reviewed Original ResearchConceptsElimination of IgGFcRn(-/-Renal lossFcRn(-/-) miceMinimal urinary excretionSerum albumin levelWild-type miceWild-type kidneysSerum concentrations of albuminProximal tubular epitheliumWild-type controlsDevelopment of hypoalbuminemiaNeonatal Fc receptorLoss of IgGLoss of albuminSerum levelsAlbumin levelsIncreased to wild-type levelsUrinary excretionSerum concentrationsFc receptorsTubular epitheliumConcentrations of albuminPlasma protein poolKidney
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