2023
Tumoral Intraductal Neoplasms of the Bile Ducts Comprise Morphologically and Genetically Distinct Entities.
Wang T, Askan G, Ozcan K, Rana S, Zehir A, Bhanot U, Yantiss R, Rao D, Wahl S, Bagci P, Balci S, Balachandran V, Jarnagin W, Adsay N, Klimstra D, Basturk O. Tumoral Intraductal Neoplasms of the Bile Ducts Comprise Morphologically and Genetically Distinct Entities. Archives Of Pathology & Laboratory Medicine 2023, 147: 1390-1401. PMID: 36821179, DOI: 10.5858/arpa.2022-0343-oa.Peer-Reviewed Original ResearchConceptsIntraductal oncocytic papillary neoplasmIntraductal papillary neoplasmIntraductal tubulopapillary neoplasmIntraductal neoplasmsPapillary neoplasmBile ductTargeted Next-Generation SequencingMale to female ratioHigh-grade dysplasiaRecurrent genetic aberrationsCopy number variantsTumor suppressor geneFollow-up informationDisease-related deathNext-generation sequencingWnt Signaling PathwayGenetically distinct entitiesCK20 expressionGenetic aberrationsFemale ratioFollow-upTubulopapillary neoplasmNeoplasmsSuppressor geneFrequent alterations
2022
A Review of Mucinous Cystic and Intraductal Neoplasms of the Pancreatobiliary Tract.
Ozcan K, Klimstra D. A Review of Mucinous Cystic and Intraductal Neoplasms of the Pancreatobiliary Tract. Archives Of Pathology & Laboratory Medicine 2022, 146: 298-311. PMID: 35192699, DOI: 10.5858/arpa.2021-0399-ra.Peer-Reviewed Original ResearchConceptsMucinous cystic neoplasmsIntraductal neoplasmsPancreatobiliary tractCystic neoplasmsPancreatic neoplasmsIntraductal papillary mucinous neoplasmPancreatic intraductal neoplasmsIntraductal oncocytic papillary neoplasmBile duct neoplasmsPapillary mucinous neoplasmCystic pancreatic neoplasmsMass-forming neoplasmIntraductal tubulopapillary neoplasmIntraductal papillary neoplasmIntraductal papillary neoplasm of bile ductSensitive imaging techniqueMucinous neoplasmsPapillary neoplasmPancreatobiliary neoplasmsPrognostic variationsGenomic alterationsTubulopapillary neoplasmNeoplasmsBile ductPathological features
2012
Intraductal Tubular Neoplasms of the Bile Ducts
Katabi N, Torres J, Klimstra D. Intraductal Tubular Neoplasms of the Bile Ducts. The American Journal Of Surgical Pathology 2012, 36: 1647-1655. PMID: 23073323, DOI: 10.1097/pas.0b013e3182684d4f.Peer-Reviewed Original ResearchConceptsIntraductal tubular neoplasmInvasive carcinoma componentBile ductIntraductal neoplasmsCarcinoma componentImmunohistochemical featuresMild to moderate cytologic atypiaFree of tumor recurrenceMemorial Sloan-Kettering Cancer CenterPancreatobiliary-type carcinomasTubular neoplasmsModerate cytologic atypiaBile duct excisionClinical follow-upOccurrence of metastasisTubular growth patternIntraductal tubulopapillary neoplasmIntraductal papillary neoplasmFoci of necrosisDuct excisionIntraductal componentTumor recurrencePapillary architectureAbdominal painCA19-9
2007
Intraductal and Papillary Variants of Acinar Cell Carcinomas
Basturk O, Zamboni G, Klimstra D, Capelli P, Andea A, Kamel N, Adsay N. Intraductal and Papillary Variants of Acinar Cell Carcinomas. The American Journal Of Surgical Pathology 2007, 31: 363-370. PMID: 17325477, DOI: 10.1097/01.pas.0000213376.09795.9f.Peer-Reviewed Original ResearchConceptsAcinar cell carcinomaIntraductal growthCell carcinomaIntraductal neoplasmsPrecursor of invasive cancerMean tumor sizePancreatic intraductal neoplasmsMarkers of ductal differentiationTime of diagnosisLack of mucinPolypoid naturePapillary variantPancreatic resectionInvasive cancerTumor sizeVariants of acinar cell carcinomaClinicopathological featuresCystic areasDuctal differentiationSolid tumorsTributary ductsDifferential diagnosisPapillary patternHistological findingsClinical significance
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