2020
Circular RNA CircMAP3K5 Acts as a MicroRNA-22-3p Sponge to Promote Resolution of Intimal Hyperplasia Via TET2-Mediated Smooth Muscle Cell Differentiation
Zeng Z, Xia L, Fan S, Zheng J, Qin J, Fan X, Liu Y, Tao J, Liu Y, Li K, Ling Z, Bu Y, Martin KA, Hwa J, Liu R, Tang WH. Circular RNA CircMAP3K5 Acts as a MicroRNA-22-3p Sponge to Promote Resolution of Intimal Hyperplasia Via TET2-Mediated Smooth Muscle Cell Differentiation. Circulation 2020, 143: 354-371. PMID: 33207953, DOI: 10.1161/circulationaha.120.049715.Peer-Reviewed Original ResearchConceptsHuman coronary artery smooth muscle cellsTet2 knockout miceCoronary artery smooth muscle cellsArtery smooth muscle cellsCircular RNAsSmooth muscle cellsVascular smooth muscle cellsWire-injured mouse femoral arteriesSmooth muscle cell differentiationCircular RNA profilingMuscle cell differentiationRNA sequencing dataLoss of TET2Coronary heart diseaseVascular SMC differentiationMiR-22-3pPlatelet-derived growth factorKnockout miceSMC differentiationMaster regulatorRNA sequencingRNA profilingPlatelet-derived growth factor-BBGene expressionSequencing data
2016
Regulation of CBL and ESR1 expression by microRNA-22-3p, 513a-5p and 625-5p may impact the pathogenesis of dust mite-induced pediatric asthma
Dong X, Xu M, Ren Z, Gu J, Lu M, Lu Q, Zhong N. Regulation of CBL and ESR1 expression by microRNA-22-3p, 513a-5p and 625-5p may impact the pathogenesis of dust mite-induced pediatric asthma. International Journal Of Molecular Medicine 2016, 38: 446-456. PMID: 27277384, PMCID: PMC4935459, DOI: 10.3892/ijmm.2016.2634.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAsthmaCase-Control StudiesChildCytokinesDemographyDown-RegulationErbB ReceptorsEstrogen Receptor alphaFemaleGene Expression ProfilingGene Expression RegulationGene Regulatory NetworksHumansInflammation MediatorsMaleMicroRNAsNF-kappa BPhosphatidylinositol 3-KinasesProto-Oncogene MasProto-Oncogene Proteins c-aktProto-Oncogene Proteins c-cblPyroglyphidaeReal-Time Polymerase Chain ReactionRNA, MessengerSyk KinaseUp-RegulationConceptsPediatric asthmaPlasma concentrationsGender-matched healthy controlsCbl proto-oncogeneMite-induced asthmaPeroxisome proliferator-activated receptorInflammatory cytokine pathwaysMicroRNA-22-3pTumor necrosis factorProliferator-activated receptorEnzyme-linked immunosorbentRegulation of CblMiR-22-3pAsthma groupIL-10Asthma attacksHealthy controlsCytokine pathwaysNecrosis factorEstrogen receptorImmune responseESR1 expressionAsthmaControl groupInvolvement of microRNAs
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