Advances in the Evolutionary Understanding of MHC Polymorphism
Radwan J, Babik W, Kaufman J, Lenz T, Winternitz J. Advances in the Evolutionary Understanding of MHC Polymorphism. Trends In Genetics 2020, 36: 298-311. PMID: 32044115, DOI: 10.1016/j.tig.2020.01.008.Peer-Reviewed Original ResearchConceptsExcess of nonsynonymous changesMHC gene familyPathogen-driven selectionVertebrate adaptive immune responsePeptide-binding domainGene genealogiesAdaptive introgressionDeleterious mutationsGene familyNonsynonymous changesGeographic subdivisionMHC polymorphismMHC genesMHC allelesComplexity of selectionCell surfaceEvolutionary understandingImmune responseAdaptive immune responsesGenesPolymorphismPeptide antigensIntrogressionHitchhikingVertebrates
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