2025
Triglycerides are an important fuel reserve for synapse function in the brain
Kumar M, Wu Y, Knapp J, Pontius C, Park D, Witte R, McAllister R, Gupta K, Rajagopalan K, De Camilli P, Ryan T. Triglycerides are an important fuel reserve for synapse function in the brain. Nature Metabolism 2025, 7: 1392-1403. PMID: 40595405, PMCID: PMC12286841, DOI: 10.1038/s42255-025-01321-x.Peer-Reviewed Original ResearchConceptsLipid dropletsFatty acidsMitochondrial ATP productionFunction in vivoActivity-dependent fashionNerve terminalsATP productionNeuronal function in vivoSynapse functionAdult male miceTriglyceride lipaseIn vivo neuronsDDHD2Neuronal bioenergeticsMale miceAcute blockElectrical silenceMetabolic supportNeuronsNerveFuel reservesElectrical activityMitochondriaCognitive functionBioenergeticsMyelin–axon interface vulnerability in Alzheimer’s disease revealed by subcellular proteomics and imaging of human and mouse brain
Cai Y, Pinheiro-de-Sousa I, Slobodyanyuk M, Chen F, Huynh T, Kanyo J, Tang P, Fuentes L, Braker A, Welch R, Huttner A, Tong L, Yuan P, Lam T, Petsalaki E, Reimand J, Nairn A, Grutzendler J. Myelin–axon interface vulnerability in Alzheimer’s disease revealed by subcellular proteomics and imaging of human and mouse brain. Nature Neuroscience 2025, 28: 1418-1435. PMID: 40514588, PMCID: PMC12395420, DOI: 10.1038/s41593-025-01973-8.Peer-Reviewed Original ResearchSubcellular proteomicsAlzheimer's diseaseFemale 5XFAD miceProteomic hitsSubcellular localizationAmyloid-bProtein aggregationLigand-receptor interactionsAD donorsLipid metabolismExpansion microscopyPostmortem human brainProteomicsAxonal outgrowthMouse brainAlzheimerNeuronal plasticityCritical sitesAberrant myelinationMyelin ensheathmentDystrophic axonsMetabolic supportMiceAxonal structureMetabolism
2024
EGFR-driven lung adenocarcinomas coopt alveolar macrophage metabolism and function to support EGFR signaling and growth.
Kuhlmann-Hogan A, Cordes T, Xu Z, Kuna R, Traina K, Robles-Oteiza C, Ayeni D, Kwong E, Levy S, Globig A, Nobari M, Cheng G, Leibel S, Homer R, Shaw R, Metallo C, Politi K, Kaech S. EGFR-driven lung adenocarcinomas coopt alveolar macrophage metabolism and function to support EGFR signaling and growth. Cancer Discovery 2024, 14: 524-545. PMID: 38241033, PMCID: PMC11258210, DOI: 10.1158/2159-8290.cd-23-0434.Peer-Reviewed Original ResearchLung adenocarcinomaGM-CSFEGFR-mutant lung adenocarcinomaGM-CSF secretionProinflammatory immune responseSuppress tumor progressionLocal immunosuppressionStatin therapyTherapeutic combinationsNovel therapiesTumor cellsTumor progressionTumor growthLung adenocarcinoma cellsEGFR phosphorylationImmune responseTransformed epitheliumCancer cellsInflammatory functionsEGFR SignalingMacrophage metabolismAlveolar macrophagesIncreased cholesterol synthesisMetabolic supportOncogenic signaling
2018
Metabolic regulation and glucose sensitivity of cortical radial glial cells
Rash BG, Micali N, Huttner AJ, Morozov YM, Horvath TL, Rakic P. Metabolic regulation and glucose sensitivity of cortical radial glial cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 2018, 115: 10142-10147. PMID: 30224493, PMCID: PMC6176632, DOI: 10.1073/pnas.1808066115.Peer-Reviewed Original ResearchConceptsRadial glial cellsGlial cellsRGC fibersCortical radial glial cellsEmbryonic cortical slicesGestational obesityCerebral cortexCortical slicesMetabolic disturbancesCortical neurogenesisMetabolic supportBrain disordersAcute lossMitochondrial transportBrain developmentIntracellular CaPotential mechanismsHyperglycemiaMitochondrial functionGlucose sensitivityMiceStem cellsPrimary stem cellsPhysiological mechanismsCells
2017
A Case of Succinyl-CoA:3-Oxoacid CoA Transferase Deficiency Presenting with Severe Acidosis in a 14-Month-Old Female: Evidence for Pathogenicity of a Point Mutation in the OXCT1 Gene
Zheng DJ, Hooper M, Spencer-Manzon M, Pierce RW. A Case of Succinyl-CoA:3-Oxoacid CoA Transferase Deficiency Presenting with Severe Acidosis in a 14-Month-Old Female: Evidence for Pathogenicity of a Point Mutation in the OXCT1 Gene. Journal Of Pediatric Intensive Care 2017, 07: 062-066. PMID: 31073471, PMCID: PMC6260335, DOI: 10.1055/s-0037-1604270.Peer-Reviewed Original ResearchMetabolic supportSevere anion gap metabolic acidosisTransferase deficiencyAnion gap metabolic acidosisPediatric intensive care unitGap metabolic acidosisIntensive care unitMonth old femaleCare unitNeonatal periodSevere acidosisMetabolic acidosisEarly managementFavorable outcomeSCOT deficiencyHigh indexOld femaleOlder ageInborn errorsAcidosisOXCT1 geneImmediate transferDeficiencyFemalesTachypnea
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