Myelin–axon interface vulnerability in Alzheimer’s disease revealed by subcellular proteomics and imaging of human and mouse brain
Cai Y, Pinheiro-de-Sousa I, Slobodyanyuk M, Chen F, Huynh T, Kanyo J, Tang P, Fuentes L, Braker A, Welch R, Huttner A, Tong L, Yuan P, Lam T, Petsalaki E, Reimand J, Nairn A, Grutzendler J. Myelin–axon interface vulnerability in Alzheimer’s disease revealed by subcellular proteomics and imaging of human and mouse brain. Nature Neuroscience 2025, 1-18. PMID: 40514588, DOI: 10.1038/s41593-025-01973-8.Peer-Reviewed Original ResearchSubcellular proteomicsAlzheimer's diseaseFemale 5XFAD miceProteomic hitsSubcellular localizationAmyloid-bProtein aggregationLigand-receptor interactionsAD donorsLipid metabolismExpansion microscopyPostmortem human brainProteomicsAxonal outgrowthMouse brainAlzheimerNeuronal plasticityCritical sitesAberrant myelinationMyelin ensheathmentDystrophic axonsMetabolic supportMiceAxonal structureMetabolism
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