2025
Effect of Aficamten Compared with Metoprolol on Echocardiographic Measures in Symptomatic Obstructive Hypertrophic Cardiomyopathy: MAPLE-HCM
Hegde S, Wang X, Garcia-Pavia P, Getchevski S, Masri A, Merkely B, Nassif M, Peña-Peña M, Barriales-Villa R, Bilen O, Burroughs M, Claggett B, Costabel J, de Barros Correia E, Dybro A, Elliott P, Lakdawala N, Mann A, Maron M, Nair A, Poulsen S, Reant P, Schulze P, Wang A, Sohn R, Berhane I, Heitner S, Jacoby D, Kupfer S, Malik F, Wohltman A, Fifer M, Solomon S, Investigators M. Effect of Aficamten Compared with Metoprolol on Echocardiographic Measures in Symptomatic Obstructive Hypertrophic Cardiomyopathy: MAPLE-HCM. Journal Of The American College Of Cardiology 2025 PMID: 40932433, DOI: 10.1016/j.jacc.2025.08.022.Peer-Reviewed Original ResearchLeft ventricular ejection fractionSymptomatic obstructive hypertrophic cardiomyopathyObstructive hypertrophic cardiomyopathyMitral valve systolic anterior motionLeft atrial volume indexAtrial volume indexSystolic anterior motionEffects of monotherapyHypertrophic cardiomyopathyAnterior motionDiastolic functionMitral regurgitationCardiac structureMeasures of LV diastolic functionLV global longitudinal strainVolume indexEchocardiographic measures of cardiac structureMeasures of cardiac structureOutflow tract gradientLV diastolic functionFirst-line therapyGlobal circumferential strainGlobal longitudinal strainVentricular ejection fractionMaximal wall thickness
2024
Impact of Aficamten on Echocardiographic Cardiac Structure and Function in Symptomatic Obstructive Hypertrophic Cardiomyopathy
Hegde S, Claggett B, Wang X, Jering K, Prasad N, Roshanali F, Masri A, Nassif M, Barriales-Villa R, Abraham T, Cardim N, Coats C, Kramer C, Maron M, Michels M, Olivotto I, Saberi S, Jacoby D, Heitner S, Kupfer S, Meng L, Wohltman A, Malik F, Solomon S, Investigators S. Impact of Aficamten on Echocardiographic Cardiac Structure and Function in Symptomatic Obstructive Hypertrophic Cardiomyopathy. Journal Of The American College Of Cardiology 2024, 84: 1789-1802. PMID: 39217556, DOI: 10.1016/j.jacc.2024.08.002.Peer-Reviewed Original ResearchLeft ventricular ejection fractionObstructive hypertrophic cardiomyopathySymptomatic obstructive hypertrophic cardiomyopathyLVOT gradientKCCQ-CSSNT-proBNPAssociated with improvementsHypertrophic cardiomyopathyKansas City Cardiomyopathy Questionnaire clinical summary scoreCardiac structureMeasures of LV diastolic functionLV global circumferential strainN-terminal pro-B-type natriuretic peptideLV global longitudinal strainLV end-systolic volumePro-B-type natriuretic peptideEchocardiographic measures of cardiac structureMeasures of cardiac structureLateral e' velocityLV diastolic functionAtrial volume indexGlobal longitudinal strainLV systolic functionPlacebo-controlled studyGlobal circumferential strain
2020
Left atrial strain and diastolic function abnormalities in obese and type 2 diabetic adolescents and young adults
Steele JM, Urbina EM, Mazur WM, Khoury PR, Nagueh SF, Tretter JT, Alsaied T. Left atrial strain and diastolic function abnormalities in obese and type 2 diabetic adolescents and young adults. Cardiovascular Diabetology 2020, 19: 163. PMID: 33004030, PMCID: PMC7531140, DOI: 10.1186/s12933-020-01139-9.Peer-Reviewed Original ResearchConceptsConduit strain rateDiastolic function abnormalitiesLV diastolic functionDiastolic functionFunction abnormalitiesT2DM patientsYoung adultsLA volumeMultivariable analysisBooster strainLeft ventricular diastolic function abnormalitiesType 2 diabetic adolescentsType 2 diabetes mellitusMitral E/Normal LA volumePrevalence of diastolicStructurally normal heartsPrevalence of abnormalitiesSpeckle tracking measurementsAtrial strainAtrial functionDiabetes mellitusEchocardiographic measuresEjection fractionHeart failure
2019
Prognostic and functional implications of left atrial late gadolinium enhancement cardiovascular magnetic resonance
Quail M, Grunseich K, Baldassarre LA, Mojibian H, Marieb MA, Cornfeld D, Soufer A, Sinusas AJ, Peters DC. Prognostic and functional implications of left atrial late gadolinium enhancement cardiovascular magnetic resonance. Journal Of Cardiovascular Magnetic Resonance 2019, 21: 2. PMID: 30602395, PMCID: PMC6317232, DOI: 10.1186/s12968-018-0514-3.Peer-Reviewed Original ResearchConceptsLA late gadolinium enhancementNew-onset atrial arrhythmiasLate gadolinium enhancementAtrial arrhythmiasAtrial late gadolinium enhancementLA functionAtrial fibrillationGadolinium enhancementCardiovascular magnetic resonance imagingNew atrial arrhythmiasPoor procedural outcomesLV diastolic functionLA ejection fractionVentricular mechanical functionCardiovascular magnetic resonanceMagnetic resonance imagingSeptal eDiastolic functionEjection fractionHazard ratioLA volumeProcedural outcomesPrognostic biomarkerCardiac diseasePrior history
2015
Aortic stiffness and left ventricular diastolic function in children with well-functioning bicuspid aortic valves
Weismann C, Lombardi K, Grell B, Northrup V, Sugeng L. Aortic stiffness and left ventricular diastolic function in children with well-functioning bicuspid aortic valves. European Heart Journal - Cardiovascular Imaging 2015, 17: 225-230. PMID: 26072912, PMCID: PMC4882883, DOI: 10.1093/ehjci/jev151.Peer-Reviewed Original ResearchConceptsBicuspid aortic valveIsolated bicuspid aortic valveDiastolic functionAortic stiffnessNo significant differenceAortic elasticityAortic valveParameters of LV diastolic functionHealthy frequency-matched controlsParameters of aortic elasticityLeft ventricular diastolic functionSubgroup analysis of childrenRetrospective review of echocardiogramsLV diastolic functionCongenital heart diseaseReview of echocardiogramsVentricular diastolic functionSignificant differenceFrequency-matched controlsLeft ventricular (LV) diastolic impairmentDiastolic impairmentAnalysis of childrenLV systolicRetrospective reviewSystolic function
2013
Aortic Stiffness and Left Ventricular Diastolic Function in Children Following Early Repair of Aortic Coarctation
Lombardi KC, Northrup V, McNamara RL, Sugeng L, Weismann CG. Aortic Stiffness and Left Ventricular Diastolic Function in Children Following Early Repair of Aortic Coarctation. The American Journal Of Cardiology 2013, 112: 1828-1833. PMID: 24035164, DOI: 10.1016/j.amjcard.2013.07.052.Peer-Reviewed Original ResearchConceptsLV diastolic functionAortic stiffness indexDiastolic functionCoA repairAortic stiffnessStiffness indexAortic elasticityAbnormal LV diastolic functionLV diastolic dysfunctionVentricular diastolic functionVentricular diastolic impairmentRepaired coarctationDiastolic dysfunctionSystolic functionBlood pressureDiastolic impairmentRetrospective reviewAortic coarctationMedian timeEarly repairLV sizeGroup NormalYounger ageAge rangeCoarctation
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