Effect of Aficamten Compared with Metoprolol on Echocardiographic Measures in Symptomatic Obstructive Hypertrophic Cardiomyopathy: MAPLE-HCM
Hegde S, Wang X, Garcia-Pavia P, Getchevski S, Masri A, Merkely B, Nassif M, Peña-Peña M, Barriales-Villa R, Bilen O, Burroughs M, Claggett B, Costabel J, de Barros Correia E, Dybro A, Elliott P, Lakdawala N, Mann A, Maron M, Nair A, Poulsen S, Reant P, Schulze P, Wang A, Sohn R, Berhane I, Heitner S, Jacoby D, Kupfer S, Malik F, Wohltman A, Fifer M, Solomon S, Investigators M. Effect of Aficamten Compared with Metoprolol on Echocardiographic Measures in Symptomatic Obstructive Hypertrophic Cardiomyopathy: MAPLE-HCM. Journal Of The American College Of Cardiology 2025 PMID: 40932433, DOI: 10.1016/j.jacc.2025.08.022.Peer-Reviewed Original ResearchLeft ventricular ejection fractionSymptomatic obstructive hypertrophic cardiomyopathyObstructive hypertrophic cardiomyopathyMitral valve systolic anterior motionLeft atrial volume indexAtrial volume indexSystolic anterior motionEffects of monotherapyHypertrophic cardiomyopathyAnterior motionDiastolic functionMitral regurgitationCardiac structureMeasures of LV diastolic functionLV global longitudinal strainVolume indexEchocardiographic measures of cardiac structureMeasures of cardiac structureOutflow tract gradientLV diastolic functionFirst-line therapyGlobal circumferential strainGlobal longitudinal strainVentricular ejection fractionMaximal wall thickness
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