2025
Effect of Aficamten Compared with Metoprolol on Echocardiographic Measures in Symptomatic Obstructive Hypertrophic Cardiomyopathy: MAPLE-HCM
Hegde S, Wang X, Garcia-Pavia P, Getchevski S, Masri A, Merkely B, Nassif M, Peña-Peña M, Barriales-Villa R, Bilen O, Burroughs M, Claggett B, Costabel J, de Barros Correia E, Dybro A, Elliott P, Lakdawala N, Mann A, Maron M, Nair A, Poulsen S, Reant P, Schulze P, Wang A, Sohn R, Berhane I, Heitner S, Jacoby D, Kupfer S, Malik F, Wohltman A, Fifer M, Solomon S, Investigators M. Effect of Aficamten Compared with Metoprolol on Echocardiographic Measures in Symptomatic Obstructive Hypertrophic Cardiomyopathy: MAPLE-HCM. Journal Of The American College Of Cardiology 2025 PMID: 40932433, DOI: 10.1016/j.jacc.2025.08.022.Peer-Reviewed Original ResearchLeft ventricular ejection fractionSymptomatic obstructive hypertrophic cardiomyopathyObstructive hypertrophic cardiomyopathyMitral valve systolic anterior motionLeft atrial volume indexAtrial volume indexSystolic anterior motionEffects of monotherapyHypertrophic cardiomyopathyAnterior motionDiastolic functionMitral regurgitationCardiac structureMeasures of LV diastolic functionLV global longitudinal strainVolume indexEchocardiographic measures of cardiac structureMeasures of cardiac structureOutflow tract gradientLV diastolic functionFirst-line therapyGlobal circumferential strainGlobal longitudinal strainVentricular ejection fractionMaximal wall thickness
2024
Impact of Aficamten on Echocardiographic Cardiac Structure and Function in Symptomatic Obstructive Hypertrophic Cardiomyopathy
Hegde S, Claggett B, Wang X, Jering K, Prasad N, Roshanali F, Masri A, Nassif M, Barriales-Villa R, Abraham T, Cardim N, Coats C, Kramer C, Maron M, Michels M, Olivotto I, Saberi S, Jacoby D, Heitner S, Kupfer S, Meng L, Wohltman A, Malik F, Solomon S, Investigators S. Impact of Aficamten on Echocardiographic Cardiac Structure and Function in Symptomatic Obstructive Hypertrophic Cardiomyopathy. Journal Of The American College Of Cardiology 2024, 84: 1789-1802. PMID: 39217556, DOI: 10.1016/j.jacc.2024.08.002.Peer-Reviewed Original ResearchLeft ventricular ejection fractionObstructive hypertrophic cardiomyopathySymptomatic obstructive hypertrophic cardiomyopathyLVOT gradientKCCQ-CSSNT-proBNPAssociated with improvementsHypertrophic cardiomyopathyKansas City Cardiomyopathy Questionnaire clinical summary scoreCardiac structureMeasures of LV diastolic functionLV global circumferential strainN-terminal pro-B-type natriuretic peptideLV global longitudinal strainLV end-systolic volumePro-B-type natriuretic peptideEchocardiographic measures of cardiac structureMeasures of cardiac structureLateral e' velocityLV diastolic functionAtrial volume indexGlobal longitudinal strainLV systolic functionPlacebo-controlled studyGlobal circumferential strainLongitudinal changes in the carotid arteries of head and neck cancer patients following radiation therapy: Results from a prospective serial imaging biomarker characterization study
Koutroumpakis E, Mohamed A, Chaftari P, Rosenthal D, Gujral D, Nutting C, Kamel S, Naser M, Kim P, Bassett R, Fuller C, Mouhayar E, Group A. Longitudinal changes in the carotid arteries of head and neck cancer patients following radiation therapy: Results from a prospective serial imaging biomarker characterization study. Radiotherapy And Oncology 2024, 195: 110220. PMID: 38467343, PMCID: PMC11380547, DOI: 10.1016/j.radonc.2024.110220.Peer-Reviewed Original ResearchIntima-media thicknessGlobal circumferential strainRadiation therapyCarotid arteryHead and neck RTHead and neck cancer patientsHead and neck cancerNeck radiation therapyCircumferential strainNeck cancer patientsCarotid intima-media thicknessCarotid artery injuryArtery duplex studiesCarotid artery stenosisNeck RTNo significant differenceNeck cancerDuplex studiesArterial injuryArtery stenosisCancer patientsMedia thicknessCarotid ultrasoundArterial elastanceCarotid
2023
Left ventricular strain in pediatric patients with bicuspid aortic valves and aortopathy
Frye R, Ittleman B, Shabanova V, Sugeng L, Steele J, Ferdman D, Karnik R. Left ventricular strain in pediatric patients with bicuspid aortic valves and aortopathy. Progress In Pediatric Cardiology 2023, 69: 101636. DOI: 10.1016/j.ppedcard.2023.101636.Peer-Reviewed Original ResearchBicuspid aortic valveLeft ventricular strainVentricular strainGlobal longitudinal strainGlobal circumferential strainAortic valvePediatric patientsEjection fractionLeft ventricle global longitudinal strainLeft ventricular global longitudinal strainBackground Bicuspid aortic valveVentricle global longitudinal strainSingle-center retrospective studyVentricular global longitudinal strainCommon congenital cardiac defectLongitudinal strainCircumferential strainAortic valve replacementNormal ejection fractionPrior cardiac interventionCongenital cardiac defectsYears of agePotential early markerLeft ventricular myocardiumSignificant differences
2021
Acute changes of left ventricular function during surgical revascularization by 3D speckle tracking
Chen W, Ortiz‐Leon X, Posada‐Martinez E, Pereira J, Dewar ML, Darr U, Geirsson A, Sugeng L, Zhu Q. Acute changes of left ventricular function during surgical revascularization by 3D speckle tracking. Echocardiography 2021, 38: 623-631. PMID: 33740279, DOI: 10.1111/echo.15040.Peer-Reviewed Original ResearchConceptsGlobal longitudinal strainLV ejection fractionTissue motion annular displacementGlobal circumferential strainLeft ventricular functionTransesophageal echocardiographyLongitudinal strainSurgical revascularizationVentricular functionAcute changesThree-dimensional speckle tracking echocardiographyTerritorial longitudinal strainCoronary artery bypassIntraoperative transesophageal echocardiographySpeckle tracking imagingLV longitudinal functionSpeckle tracking echocardiographyCoronary perfusion territoriesRegional longitudinal strainArtery bypassCABG surgeryEjection fractionClinical outcomesFunctional recoveryAbsence of changes
2020
Speckle tracking echocardiography can predict subclinical myocardial involvement in patients with sarcoidosis: A meta‐analysis
Barssoum K, Altibi A, Rai D, Kumar A, Kharsa A, Chowdhury M, Thakkar S, Shahid S, Abdelazeem M, Abuzaid A, Baibhav B, Parikh V, Feitell S, Balmer‐Swain M, Rao M, Amsallem M, Nanda N. Speckle tracking echocardiography can predict subclinical myocardial involvement in patients with sarcoidosis: A meta‐analysis. Echocardiography 2020, 37: 2061-2070. PMID: 33058271, DOI: 10.1111/echo.14886.Peer-Reviewed Original ResearchConceptsLeft ventricular global longitudinal strainGlobal circumferential strainSpeckle tracking echocardiographyStandardized mean differenceCardiac sarcoidosisCardiac magnetic resonanceSarcoidosis groupTracking echocardiographyHealthy controlsConfidence intervalsExtra-cardiac sarcoidosisGlobal longitudinal strainSubclinical myocardial involvementMeta-analysisScreening of CSAdvanced imaging modalitiesRandom-effects modelEnglish-language articlesPositron emission tomographyMyocardial involvementSarcoidosis patientsCardiac symptomsFDG-PETLongitudinal strainEchocardiographyAssociation Between Left Ventricular Mechanical Deformation and Myocardial Fibrosis in Nonischemic Cardiomyopathy
Csecs I, Pashakhanloo F, Paskavitz A, Jang J, Al‐Otaibi T, Neisius U, Manning W, Nezafat R. Association Between Left Ventricular Mechanical Deformation and Myocardial Fibrosis in Nonischemic Cardiomyopathy. Journal Of The American Heart Association 2020, 9: e016797. PMID: 33006296, PMCID: PMC7792406, DOI: 10.1161/jaha.120.016797.Peer-Reviewed Original ResearchConceptsLate gadolinium enhancementSeptal late gadolinium enhancementLV ejection fractionNonischemic cardiomyopathyExtent of fibrosisCardiovascular magnetic resonanceEjection fractionImpaired global circumferential strainImpaired LV ejection fractionLate gadolinium enhancement groupsDepressed LV ejection fractionClinical cardiovascular magnetic resonanceLeft ventricular (LVLGE-negative groupCircumferential strainGlobal radial strainGlobal longitudinal strainRadial strainGlobal circumferential strainLV deformation parametersGlobal LV functionAdverse cardiovascular outcomesLGE-positiveNonischemic fibrosisFibrosis burden
2019
P310Differentiation between arrhythmogenic right ventricular cardiomyopathy and athlete's heart using cardiac magnetic resonance based derived parameters and strain analysis
Czimbalmos C, Csecs I, Dohy Z, Toth A, Suhai F, Szabo L, Kiss O, Sydo N, Kovacs A, Lakatos B, Merkely B, Vago H. P310Differentiation between arrhythmogenic right ventricular cardiomyopathy and athlete's heart using cardiac magnetic resonance based derived parameters and strain analysis. European Heart Journal 2019, 40: ehz747.0145. DOI: 10.1093/eurheartj/ehz747.0145.Peer-Reviewed Original ResearchArrhythmogenic right ventricular cardiomyopathyArrhythmogenic right ventricular cardiomyopathy patientsTask Force criteriaRight ventricular cardiomyopathyCMR parametersARVC patientsEjection fractionVentricular cardiomyopathyDiagnostic accuracyRevised task force criteriaAthlete's heartForce criteriaDiagnosing ARVCRegional strain valuesRV global strainRV strain parametersEnd-diastolic volume ratioRight ventricular end-systolicGlobal circumferential strainRV strain rateCardiac magnetic resonanceStroke volume indexVentricular end-systolicT-wave inversionCut-off value
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