2015
Leiomyoma-derived transforming growth factor-β impairs bone morphogenetic protein-2-mediated endometrial receptivity
Doherty LF, Taylor HS. Leiomyoma-derived transforming growth factor-β impairs bone morphogenetic protein-2-mediated endometrial receptivity. Fertility And Sterility 2015, 103: 845-852. PMID: 25596622, PMCID: PMC4363085, DOI: 10.1016/j.fertnstert.2014.12.099.Peer-Reviewed Original ResearchConceptsEndometrial stromal cellsLeukemia inhibitory factorEndometrial receptivityTGF receptorElevated TGF-β levelsCultured endometrial stromal cellsTGF-β receptor type IITGF-β antibodyTGF-β levelsReceptor type 1aReceptor type IIBMP receptor type 1AEnzyme-linked immunosorbentRecombinant human BMP-2LIF expressionSymptomatic leiomyomasPregnancy lossSurgical specimensPretreatment levelsUterine leiomyomaReceptor type 1BMAIN OUTCOMELeiomyoma cellsLeiomyomaHuman BMP-2
2013
Tissue Selective Estrogen Complexes (TSECs) Differentially Modulate Markers of Proliferation and Differentiation in Endometrial Cells
Kulak J, Ferriani RA, Komm BS, Taylor HS. Tissue Selective Estrogen Complexes (TSECs) Differentially Modulate Markers of Proliferation and Differentiation in Endometrial Cells. Reproductive Sciences 2013, 20: 129-137. PMID: 23171676, PMCID: PMC3826278, DOI: 10.1177/1933719112463251.Peer-Reviewed Original ResearchConceptsTissue selective estrogen complexSelective estrogen receptor modulatorsLeukemia inhibitory factorProgesterone receptorBazedoxifene acetateEndometrial effectsEndometrial proliferationEstrogen complexEffects of raloxifeneRisk of estrogenVehicle-treated controlsEndometrial cell proliferationEstrogen receptor modulatorsEndometrial gene expressionMessenger RNA expressionDifferential effectsEndometrial safetyEstrogen-responsive genesEndometrial hyperplasiaLIF expressionPR expressionEndometrial cellsReceptor modulatorsMore estrogenIshikawa cells
2010
Leiomyoma Simultaneously Impair Endometrial BMP-2-Mediated Decidualization and Anticoagulant Expression through Secretion of TGF-β3
Sinclair DC, Mastroyannis A, Taylor HS. Leiomyoma Simultaneously Impair Endometrial BMP-2-Mediated Decidualization and Anticoagulant Expression through Secretion of TGF-β3. The Journal Of Clinical Endocrinology & Metabolism 2010, 96: 412-421. PMID: 21084396, PMCID: PMC3048319, DOI: 10.1210/jc.2010-1450.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntithrombin IIIBlood CoagulationBone Morphogenetic Protein 2Cells, CulturedDeciduaDNA, ComplementaryEnzyme-Linked Immunosorbent AssayFemaleHumansImmunohistochemistryInfertility, FemaleLeiomyomaMenorrhagiaMiddle AgedPlasminogen Activator Inhibitor 1Reverse Transcriptase Polymerase Chain ReactionRNAStromal CellsThrombomodulinTransforming Growth Factor beta3Uterine NeoplasmsConceptsEndometrial stromal cellsAntithrombin IIIPAI-1Bone morphogenetic protein receptorTGF-β3Primary endometrial stromal cellsEffects of leiomyomaReproductive-age womenPlasminogen activator inhibitor-1Expression of HOXA10TGF-β3 treatmentEndometrial gene expressionUniversity Medical CenterLess PAI-1Activator inhibitor-1Endometrial defectQuantitative RT-PCREndometrial decidualizationMenstrual bleedingLIF expressionMiscarriage riskUterine leiomyomaMedical CenterReproductive dysfunctionCase control
2005
Removal of hydrosalpinges increases endometrial leukaemia inhibitory factor (LIF) expression at the time of the implantation window
Seli E, Kayisli UA, Cakmak H, Bukulmez O, Bildirici I, Guzeloglu-Kayisli O, Arici A. Removal of hydrosalpinges increases endometrial leukaemia inhibitory factor (LIF) expression at the time of the implantation window. Human Reproduction 2005, 20: 3012-3017. PMID: 16024536, DOI: 10.1093/humrep/dei188.Peer-Reviewed Original ResearchConceptsLeukemia inhibitory factorInfertile womenLIF expressionFertile controlsExpression of LIFLeukemia inhibitory factor expressionAdverse effectsEndometrial LIF expressionPresence of hydrosalpingesWindow of implantationIVF-embryo transferGlandular epithelial cellsWestern blot findingsLIF immunoreactivityLIF levelsEndometrial receptivityEndometrial expressionImplantation windowPregnancy rateHydrosalpingesSalpingectomyImmunohistochemical analysisLow implantationInhibitory factorFactor expression
1998
Leukemia Inhibitory Factor in Human Reproduction
Senturk L, Arici A. Leukemia Inhibitory Factor in Human Reproduction. American Journal Of Reproductive Immunology 1998, 39: 144-151. PMID: 9506212, DOI: 10.1111/j.1600-0897.1998.tb00346.x.Peer-Reviewed Original ResearchConceptsLeukemia inhibitory factorFallopian tubeMenstrual cycleHuman endometriumMenstrual cycle-dependent mannerInhibitory factorRole of LIFEffects of LIFHuman reproductionEndometrial LIF expressionMyeloid leukemic cell linesTime of implantationTime of ovulationLIF levelsOvulatory eventsLIF expressionInterleukin-6 familyStromal cell culturesEndometrial tissueInflammatory cytokinesLeukemic cell linesPeripheral neuronsPleiotropic cytokineSuccessful implantationOvarian follicles
1995
Modulation of leukemia inhibitory factor gene expression and protein biosynthesis in human endometrium
Arici A, Engin O, Attar E, Olive D. Modulation of leukemia inhibitory factor gene expression and protein biosynthesis in human endometrium. The Journal Of Clinical Endocrinology & Metabolism 1995, 80: 1908-1915. PMID: 7775640, DOI: 10.1210/jcem.80.6.7775640.Peer-Reviewed Original ResearchMeSH KeywordsAdultBloodCells, CulturedCulture MediaDeciduaEndometriumEpidermal Growth FactorFemaleGene Expression RegulationGrowth InhibitorsHumansInterferon-gammaInterleukin-1Interleukin-6Leukemia Inhibitory FactorLymphokinesMiddle AgedPlatelet-Derived Growth FactorPregnancyProtein BiosynthesisRNA, MessengerTransforming Growth Factor betaTumor Necrosis Factor-alphaConceptsExpression of LIFLeukemia inhibitory factorLIF expressionLIF mRNAEndometrial cellsGrowth factorHuman endometriumLeukemia inhibitory factor gene expressionMenstrual cycle-dependent mannerRole of LIFSteroid hormonesHuman implantationLIF mRNA expressionEndometrial stromal cellsEndometrium/deciduaHuman endometrial cellsPlatelet-derived growth factorEndometrial gland cellsMessenger ribonucleic acid levelsRibonucleic acid levelsMidluteal endometriumFactor gene expressionTime-dependent mannerFirst trimesterTumor necrosis
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