2015
Leiomyoma-derived transforming growth factor-β impairs bone morphogenetic protein-2-mediated endometrial receptivity
Doherty LF, Taylor HS. Leiomyoma-derived transforming growth factor-β impairs bone morphogenetic protein-2-mediated endometrial receptivity. Fertility And Sterility 2015, 103: 845-852. PMID: 25596622, PMCID: PMC4363085, DOI: 10.1016/j.fertnstert.2014.12.099.Peer-Reviewed Original ResearchConceptsEndometrial stromal cellsLeukemia inhibitory factorEndometrial receptivityTGF receptorElevated TGF-β levelsCultured endometrial stromal cellsTGF-β receptor type IITGF-β antibodyTGF-β levelsReceptor type 1aReceptor type IIBMP receptor type 1AEnzyme-linked immunosorbentRecombinant human BMP-2LIF expressionSymptomatic leiomyomasPregnancy lossSurgical specimensPretreatment levelsUterine leiomyomaReceptor type 1BMAIN OUTCOMELeiomyoma cellsLeiomyomaHuman BMP-2
2007
Transforming Growth Factor- Signaling in Normal and Malignant Hematopoiesis
Isufi I, Seetharam M, Zhou L, Sohal D, Opalinska J, Pahanish P, Verma A. Transforming Growth Factor- Signaling in Normal and Malignant Hematopoiesis. Journal Of Interferon & Cytokine Research 2007, 27: 543-552. PMID: 17651015, DOI: 10.1089/jir.2007.0009.Peer-Reviewed Original ResearchConceptsIntracellular TGF-beta signalingFuture therapeutic interventionsImportant physiologic regulatorTGF-beta receptorsTGF-beta signalingPremalignant stateLymphoid neoplasmsSmall molecule inhibitorsMyeloid cellsTGF receptorTherapeutic interventionsTumor growthHematopoietic stem cellsPhysiologic regulatorTumor microenvironmentGrowth factorGrowth factor signalingMolecule inhibitorsQuiescent hematopoietic stem cellsStem cellsFactor signalingReceptorsCell growthLate progenitorsMalignant hematopoiesis
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