2015
Effects of ospemifene on the female reproductive and urinary tracts
Archer DF, Carr BR, Pinkerton JV, Taylor HS, Constantine GD. Effects of ospemifene on the female reproductive and urinary tracts. Menopause The Journal Of The North American Menopause Society 2015, 22: 786-796. PMID: 25423325, PMCID: PMC4481022, DOI: 10.1097/gme.0000000000000365.Peer-Reviewed Original ResearchConceptsEstrogen receptor agonist/antagonistReceptor agonists/antagonistsAgonists/antagonistsVaginal atrophyVaginal tissueSelective estrogen receptor modulatorsEffects of ospemifenePostmenopausal women's healthRelief of symptomsEstrogen receptor modulatorsAgonist/antagonist effectsUrinary tract tissuesHormone-responsive tissuesTissue-dependent responseEndometrial histopathologyEndometrial safetyEstrogen therapyClinical effectsTransvaginal ultrasoundMenopausal symptomsUrinary tractPreclinical dataCytologic examinationVaginal effectsPreclinical models
2014
Differential effects of menopausal therapies on the endometrium
Mirkin S, Archer DF, Taylor HS, Pickar JH, Komm BS. Differential effects of menopausal therapies on the endometrium. Menopause The Journal Of The North American Menopause Society 2014, 21: 899-908. PMID: 24518153, DOI: 10.1097/gme.0000000000000186.Peer-Reviewed Original ResearchConceptsTissue selective estrogen complexSelective estrogen receptor modulatorsEstrogen-progestin therapyEndometrial profileEndometrial safetyEndometrial effectsEstrogen therapyMenopausal symptomsEstrogen receptor degradationNew hormone therapiesIndividual selective estrogen receptor modulatorsIrregular uterine bleedingIncidence of hyperplasiaEstrogen receptor modulatorsMenopausal therapyTolerability profileUterine bleedingEndometrial proliferationHormone therapyPostmenopausal womenEndometrial cancerClinical findingsSafety profileAvailable treatmentsReceptor modulators
2013
Tissue Selective Estrogen Complexes (TSECs) Differentially Modulate Markers of Proliferation and Differentiation in Endometrial Cells
Kulak J, Ferriani RA, Komm BS, Taylor HS. Tissue Selective Estrogen Complexes (TSECs) Differentially Modulate Markers of Proliferation and Differentiation in Endometrial Cells. Reproductive Sciences 2013, 20: 129-137. PMID: 23171676, PMCID: PMC3826278, DOI: 10.1177/1933719112463251.Peer-Reviewed Original ResearchConceptsTissue selective estrogen complexSelective estrogen receptor modulatorsLeukemia inhibitory factorProgesterone receptorBazedoxifene acetateEndometrial effectsEndometrial proliferationEstrogen complexEffects of raloxifeneRisk of estrogenVehicle-treated controlsEndometrial cell proliferationEstrogen receptor modulatorsEndometrial gene expressionMessenger RNA expressionDifferential effectsEndometrial safetyEstrogen-responsive genesEndometrial hyperplasiaLIF expressionPR expressionEndometrial cellsReceptor modulatorsMore estrogenIshikawa cells
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