2024
Tau propagation in the brain olfactory circuits is associated with smell perception changes in aging
Diez I, Ortiz-Terán L, Ng T, Albers M, Marshall G, Orwig W, Kim C, Bueichekú E, Montal V, Olofsson J, Vannini P, El Fahkri G, Sperling R, Johnson K, Jacobs H, Sepulcre J. Tau propagation in the brain olfactory circuits is associated with smell perception changes in aging. Nature Communications 2024, 15: 4809. PMID: 38844444, PMCID: PMC11156945, DOI: 10.1038/s41467-024-48462-3.Peer-Reviewed Original ResearchConceptsOlfactory systemMedial temporal lobe structuresCognitively normal older adultsOlfactory pathwayOdor identification deficitsNormal older adultsTemporal lobe structuresTau accumulationAlzheimer's diseaseIdentification deficitsGenetic vulnerabilityLobe structuresCortical systemsOlfactory circuitsAssociated with tau accumulationIdentification measuresCortical neurodegenerationOlder adultsPiB-PETTau propagationTau progressionPathological aggregationGenetic backgroundDiffusion MRIPredictive power
2007
Interactions between attention and memory
Chun MM, Turk-Browne NB. Interactions between attention and memory. Current Opinion In Neurobiology 2007, 17: 177-184. PMID: 17379501, DOI: 10.1016/j.conb.2007.03.005.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsMedial temporal lobe structuresRole of attentionDivision of attentionFrontal-parietal networkTemporal lobe structuresCognitive neuroscienceSpatial orientingAttention determineAttention taskConscious memoryUnconscious memoryConcurrent tasksSuch memoriesLobe structuresMemoryBrain areasStimuliTaskAttentionOrientingNeuroscienceLimited capacityRecent evidenceHippocampusInterdependence
2003
Amygdala and Hippocampal Volumes in Adolescents and Adults With Bipolar Disorder
Blumberg HP, Kaufman J, Martin A, Whiteman R, Zhang JH, Gore JC, Charney DS, Krystal JH, Peterson BS. Amygdala and Hippocampal Volumes in Adolescents and Adults With Bipolar Disorder. JAMA Psychiatry 2003, 60: 1201-1208. PMID: 14662552, DOI: 10.1001/archpsyc.60.12.1201.Peer-Reviewed Original ResearchConceptsHippocampal volumeMedial temporal lobe structuresTemporal lobe structuresBipolar disorderIllness featuresVeterans Affairs Medical CenterLobe structuresRepeated-measures statistical analysisCourse of illnessTotal brain volumeAmygdala volume reductionsBD type IAnatomic magnetic resonanceHealthy comparison subjectsPaucity of dataVolume reductionSignificant volume reductionVolumetric abnormalitiesNeurodegenerative changesIllness durationOutpatient treatmentUniversity HospitalGreater effect sizeMedical CenterHippocampal region
1999
Memory deficits for implicit contextual information in amnesic subjects with hippocampal damage
Chun M, Phelps E. Memory deficits for implicit contextual information in amnesic subjects with hippocampal damage. Nature Neuroscience 1999, 2: 844-847. PMID: 10461225, DOI: 10.1038/12222.Peer-Reviewed Original ResearchConceptsImplicit contextual informationContextual informationAdjacent medial temporal lobe structuresMedial temporal memory systemMemory systemMedial temporal lobe structuresImplicit contextual learningTemporal lobe structuresAmnesic patientsAmnesic subjectsMemory tracesConscious awarenessSkill learningVisual searchVisual contextMemory deficitsMultiple cuesContextual learningLobe structuresHippocampal damageTarget objectNeural structuresTaskLearningCues
1997
Memory deficits in schizophrenia: inadequate assimilation or true amnesia? Findings from the Wechsler Memory Scale--revised.
Hawkins KA, Sullivan TE, Choi EJ. Memory deficits in schizophrenia: inadequate assimilation or true amnesia? Findings from the Wechsler Memory Scale--revised. Journal Of Psychiatry And Neuroscience 1997, 22: 169-79. PMID: 9183115, PMCID: PMC1188849.Peer-Reviewed Original ResearchConceptsMemory deficitsWechsler Memory Scale-RevisedMedial temporal lobe structuresTemporal lobe structuresSchizophrenia spectrum patientsHippocampal dysfunctionSchizophrenia patientsTrue amnesiaWechsler Memory ScalePatientsImpaired attentionLobe structuresWechsler Adult Intelligence Scale-RevisedPsychiatric controlsSchizophreniaDysfunctionMemory ScaleDeficitsMemory testFindingsQuantitative MRI volume changes in late onset schizophrenia and Alzheimer's disease compared to normal controls
Barta P, Powers R, Aylward E, Chase G, Harris G, Rabins P, Tune L, Pearlson G. Quantitative MRI volume changes in late onset schizophrenia and Alzheimer's disease compared to normal controls. Psychiatry Research 1997, 68: 65-75. PMID: 9104754, DOI: 10.1016/s0925-4927(96)02751-5.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingOnset schizophreniaAlzheimer's diseaseNormal controlsMRI volume changesLate-onset schizophreniaLateral temporal lobe structuresNon-cognitive symptomsModerate cognitive impairmentTemporal lobe structuresAnterior superior temporal gyrusNormal elderly controlsMedial temporal regionsSuperior temporal gyrusPatient groupSTG volumeAD patientsElderly controlsCognitive impairmentResonance imagingTemporal gyrusTemporal regionsPatientsLobe structuresDisease
1996
Exploratory factor analysis of MRI brain structure measures in schizophrenia
Tien A, Eaton W, Schlaepfer T, McGilchrist I, Menon R, Richard P, Aylward E, Barta P, Strauss M, Pearlson G. Exploratory factor analysis of MRI brain structure measures in schizophrenia. Schizophrenia Research 1996, 19: 93-101. PMID: 8789907, DOI: 10.1016/0920-9964(96)88520-3.Peer-Reviewed Original ResearchConceptsSuperior temporal gyrusSchizophrenia groupNormal groupTemporal gyrusStructural brain abnormalitiesLateral temporal lobe structuresBrain volume measuresTemporal lobe structuresSpecific brain regionsPosterior superior temporal gyrusBrain structure measuresBasal gangliaBrain abnormalitiesCortical greyEntorhinal cortexBrain regionsSchizophrenic subjectsNeuropsychiatric dataLobe structuresSchizophreniaSignificant differencesSignificant correlationGray regionGyrusFactor structure
1992
Callosal Morphology Concurs With Neurobehavioral and Neuropathological Findings in Two Neurodevelopmental Disorders
Wang P, Doherty S, Hesselink J, Bellugi U. Callosal Morphology Concurs With Neurobehavioral and Neuropathological Findings in Two Neurodevelopmental Disorders. JAMA Neurology 1992, 49: 407-411. PMID: 1532713, DOI: 10.1001/archneur.1992.00530280101029.Peer-Reviewed Original ResearchConceptsWilliams syndromeFrontal lobe functionFrontal lobe dysfunctionFrontal lobe structuresConvergence of findingsFrontal lobe projectionsDown syndromeNeuropsychological profileLobe functionNeuropsychological findingsLobe structuresNeuroscientific investigationsNeurodevelopmental disordersMagnetic resonance imagingCorpus callosumCallosaControl subjectsResonance imagingNeuropathological findingsHypofrontalityComputer-assisted morphometryFindingsNeuroimagingSubjectsNeurobehavior
1991
MRI of the temporal lobe: Normal variations, with special reference toward epilepsy
Bronen R, Cheung G. MRI of the temporal lobe: Normal variations, with special reference toward epilepsy. Magnetic Resonance Imaging 1991, 9: 501-507. PMID: 1779721, DOI: 10.1016/0730-725x(91)90036-l.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingTemporal hornTemporal lobeCollateral sulcusCoronal magnetic resonance imagingTemporal horn dilatationMild asymmetryRight temporal lobeTemporal lobe structuresHippocampal sclerosisChoroidal fissureNormal variationMild enlargementFrequent findingHippocampal headNormal volunteersWhite matterAlzheimer's diseaseResonance imagingLobe structuresOccipitotemporal sulcusAdjacent vesselsHead rotationSclerosisSulcus
1990
Verbal memory impairment correlates with hippocampal pyramidal cell density.
Sass K, Spencer D, Kim J, Westerveld M, Novelly R, Lencz T. Verbal memory impairment correlates with hippocampal pyramidal cell density. Neurology 1990, 40: 1694-7. PMID: 2234424, DOI: 10.1212/wnl.40.11.1694.Peer-Reviewed Original ResearchConceptsTemporal seizure focusSeizure focusMemory impairmentSurgical removalMesial temporal lobe structuresMesial temporal structuresPyramidal cell densityGranule cell layerHippocampal subfields CA1Temporal lobe structuresVerbal memory impairmentRefractory epilepsySelective Reminding TestHilar areaImpairment correlatesTemporal lobeBlinded observersSubfields CA1Cell countArea dentataVolumetric cell densityPatientsLobe structuresImpairmentVerbal Selective Reminding Test
1989
Temporal lobe measurement in primary affective disorder by magnetic resonance imaging
Hauser P, Altshuler LL, Berrettini W, Dauphinais ID, Gelernter J, Post RM. Temporal lobe measurement in primary affective disorder by magnetic resonance imaging. Journal Of Neuropsychiatry 1989, 1: 128-134. PMID: 2521053, DOI: 10.1176/jnp.1.2.128.Peer-Reviewed Original ResearchConceptsPrimary affective disorderTemporal lobeAffective disordersCerebral areasSpecific temporal lobe structuresTemporal lobe structuresMagnetic resonance imagingNormal controlsNormal subjectsInterpeduncular cisternBrain scansCoronal slicesResonance imagingPatientsLobe structuresDisordersLobeSame hemisphereRelative decreaseMagnetic resonanceSubjects
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