2025
The UMPIRE study: A first‐in‐human multicenter trial of bilateral subscalp monitoring for epileptic seizure detection
Halliday A, Gillinder L, Lai A, Seneviratne U, Fontenot H, Cameron T, McLean K, Niemiec A, Raghupathi R, Ganguly T, Ellis C, Conrad E, Briggs R, Bulluss K, Kwan P, Perucca P, O'Brien T, McGonigal A, Gutman M, Papacostas J, Fong M, Lee A, Crompton D, Laing J, Wijayath M, Morokoff A, Murphy M, D'Souza W, Cook M. The UMPIRE study: A first‐in‐human multicenter trial of bilateral subscalp monitoring for epileptic seizure detection. Epilepsia 2025 PMID: 40445205, DOI: 10.1111/epi.18458.Peer-Reviewed Original ResearchAdverse eventsInterictal dischargesScalp video-EEG monitoringProcedure-related adverse eventsFirst-in-human studyDevice-related adverse eventsEEG recordingsScalp recordingsVideo-EEG monitoringLong-term seizure monitoringClinically relevant findingsPotential clinical utilityTemporal seizure focusScalp EEG recordingsPatient self-reportPostsurgical painHypothalamic hamartomaElectrographic seizuresAdult patientsBilateral recordingsUnilateral recordingsPatient groupPrimary outcomeSeizure frequencyLong-term EEG recordings
2018
Subfield-specific tractography of the hippocampus in epilepsy patients at 7 Tesla
Rutland J, Feldman R, Delman B, Panov F, Fields M, Marcuse L, Hof P, Lin H, Balchandani P. Subfield-specific tractography of the hippocampus in epilepsy patients at 7 Tesla. Seizure 2018, 62: 3-10. PMID: 30245458, PMCID: PMC6221989, DOI: 10.1016/j.seizure.2018.09.005.Peer-Reviewed Original ResearchConceptsMRI-negative patientsHealthy volunteersEpilepsy patientsMRI-negative epilepsy patientsHippocampal subfieldsDiffusion magnetic resonance imagingDetect subtle abnormalitiesTemporal seizure focusMagnetic resonance imagingAdvanced imaging techniquesSurgical treatmentPatients suspectedSurgical interventionAbnormal connectionSeizure focusPatientsResonance imagingFiber densityHippocampalEpilepsySeizuresImaging techniquesStructural imagingVolunteersProbabilistic tractography
1990
Verbal memory impairment correlates with hippocampal pyramidal cell density.
Sass K, Spencer D, Kim J, Westerveld M, Novelly R, Lencz T. Verbal memory impairment correlates with hippocampal pyramidal cell density. Neurology 1990, 40: 1694-7. PMID: 2234424, DOI: 10.1212/wnl.40.11.1694.Peer-Reviewed Original ResearchConceptsTemporal seizure focusSeizure focusMemory impairmentSurgical removalMesial temporal lobe structuresMesial temporal structuresPyramidal cell densityGranule cell layerHippocampal subfields CA1Temporal lobe structuresVerbal memory impairmentRefractory epilepsySelective Reminding TestHilar areaImpairment correlatesTemporal lobeBlinded observersSubfields CA1Cell countArea dentataVolumetric cell densityPatientsLobe structuresImpairmentVerbal Selective Reminding Test
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