2023
Anatomical Diversity of the Adult Corticospinal Tract Revealed by Single-Cell Transcriptional Profiling
Golan N, Ehrlich D, Bonanno J, O'Brien R, Murillo M, Kauer S, Ravindra N, Van Dijk D, Cafferty W. Anatomical Diversity of the Adult Corticospinal Tract Revealed by Single-Cell Transcriptional Profiling. Journal Of Neuroscience 2023, 43: 7929-7945. PMID: 37748862, PMCID: PMC10669816, DOI: 10.1523/jneurosci.0811-22.2023.Peer-Reviewed Original ResearchConceptsCorticospinal tract neuronsCorticospinal tractAdult corticospinal tractIrreversible functional deficitsCortical layer 2/3Lumbar spinal cordSpinal cord injuryLayer 5 neuronsClasses of neuronsMolecular heterogeneityAxon collateralizationTract neuronsCord injuryRetrograde labelingMotor pathwaysFemale miceFunctional deficitsLayer 2/3Primary axonsSpinal cordTerminal fieldsNeuron subtypesAdult tractTherapeutic interventionsSingle-cell RNA sequencing
2021
Rab27a-Dependent Paracrine Communication Controls Dendritic Spine Formation and Sensory Responses in the Barrel Cortex
Zhang L, Zhang X, Hsieh LS, Lin TV, Bordey A. Rab27a-Dependent Paracrine Communication Controls Dendritic Spine Formation and Sensory Responses in the Barrel Cortex. Cells 2021, 10: 622. PMID: 33799820, PMCID: PMC8000154, DOI: 10.3390/cells10030622.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCells, CulturedDendritic SpinesExcitatory Postsynaptic PotentialsExtracellular VesiclesFemaleGene Expression Regulation, DevelopmentalGestational AgeMiceParacrine CommunicationPregnancyPyramidal Cellsrab27 GTP-Binding ProteinsSensory Receptor CellsSomatosensory CortexSynaptic TransmissionVibrissaeConceptsSmall extracellular vesiclesL4 neuronsParacrine communicationExcitatory synaptic transmissionRelease of sEVsDendritic spine formationCell-autonomous effectsRisk of autismL2/3 neuronsPyramidal neuronsLayer 2/3Somatosensory cortexBarrel cortexCortical neuronsSynaptic transmissionWhisker stimulationSomatosensory informationJuvenile miceSynaptic connectivitySynaptic integrationSpine formationBrain developmentNeuronsSensory stimulationSpine development
2019
Enhanced Population Coding for Rewarded Choices in the Medial Frontal Cortex of the Mouse
Siniscalchi MJ, Wang H, Kwan AC. Enhanced Population Coding for Rewarded Choices in the Medial Frontal Cortex of the Mouse. Cerebral Cortex 2019, 29: 4090-4106. PMID: 30615132, PMCID: PMC6735259, DOI: 10.1093/cercor/bhy292.Peer-Reviewed Original ResearchConceptsMedial frontal cortexInstrumental behaviorFrontal cortexAuditory discrimination taskSecondary motor regionsSelection of actionsNeural representationDiscrimination taskNeural ensemble activityReward magnitudeChoice signalsReward amountUnrewarded choicesPast choicesMotor regionsLayer 2/3Rodent brainProbabilistic outcomesCategorical presenceBehavioral effectsPopulation codingEnsemble activityOutcomesCortexConsistent influence
2015
Layer 4 Pyramidal Neurons Exhibit Robust Dendritic Spine Plasticity In Vivo after Input Deprivation
Miquelajauregui A, Kribakaran S, Mostany R, Badaloni A, Consalez G, Portera-Cailliau C. Layer 4 Pyramidal Neurons Exhibit Robust Dendritic Spine Plasticity In Vivo after Input Deprivation. Journal Of Neuroscience 2015, 35: 7287-7294. PMID: 25948276, PMCID: PMC4420789, DOI: 10.1523/jneurosci.5215-14.2015.Peer-Reviewed Original ResearchConceptsPyramidal neuronsInput deprivationWhisker trimmingSynaptic plasticityLayer 4 pyramidal neuronsDendritic spine lossDendritic spine plasticitySensory processingDendritic spine dynamicsRobust synaptic plasticityL4 neuronsSpine lossCre miceLayer 2/3Spine plasticityTransgenic miceElectrophysiological propertiesSpine dynamicsCortex exhibitNeuronsDeprivation resultsTwo-photon microscopyApical tuftMiceVivo
2009
Effect of the environment on the dendritic morphology of the rat auditory cortex
Bose M, Muñoz‐llancao P, Roychowdhury S, Nichols J, Jakkamsetti V, Porter B, Byrapureddy R, Salgado H, Kilgard M, Aboitiz F, Dagnino‐Subiabre A, Atzori M. Effect of the environment on the dendritic morphology of the rat auditory cortex. Synapse 2009, 64: 97-110. PMID: 19771593, PMCID: PMC2830877, DOI: 10.1002/syn.20710.Peer-Reviewed Original ResearchConceptsApical dendritic lengthBasal dendritic lengthApical dendritesDendritic lengthAuditory cortexSpine densityBasal dendritesShorter apical dendritesGolgi-Cox staining techniqueLayer-specific patternRat auditory cortexShort basal dendritesPrimary auditory cortexSensory deafnessInduce similar changesInfragranular neuronsLayer 2/3Neocortical plasticityExcitatory synapsesSholl analysisEnvironmental enrichmentStressed animalsGolgi-CoxStress-induced changesEnvironmental manipulations
2003
Adaptation and Temporal Decorrelation by Single Neurons in the Primary Visual Cortex
Wang X, Liu Y, Sanchez-Vives M, McCormick D. Adaptation and Temporal Decorrelation by Single Neurons in the Primary Visual Cortex. Journal Of Neurophysiology 2003, 89: 3279-3293. PMID: 12649312, DOI: 10.1152/jn.00242.2003.Peer-Reviewed Original ResearchConceptsPrimary visual cortical neuronsVisual cortical slicesCellular mechanismsVisual cortical neuronsIntrinsic membrane propertiesPrimary visual cortexPossible cellular mechanismsSensory inputSlow afterhyperpolarizationIntrinsic ionic currentsCortical slicesLayer 2/3Cortical neuronsNeocortical neuronsIntracellular injectionV1 neuronsNeuronal responsesVisual cortexEfficient neural codingModel neuronsReal-world sensory inputsNeuronsIonic currentsProlonged changesSingle neurons
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