2013
Restoration of Glutamatergic Transmission by Dopamine D4 Receptors in Stressed Animals*
Yuen EY, Zhong P, Li X, Wei J, Yan Z. Restoration of Glutamatergic Transmission by Dopamine D4 Receptors in Stressed Animals*. Journal Of Biological Chemistry 2013, 288: 26112-26120. PMID: 23884421, PMCID: PMC3764814, DOI: 10.1074/jbc.m112.396648.Peer-Reviewed Original ResearchConceptsD4 receptorsDopamine D4 receptorExcitatory transmissionGlutamatergic transmissionPrefrontal cortexAMPA receptor-mediated synaptic transmissionReceptor-mediated synaptic transmissionCalcium/calmodulin kinase II activityEffects of D4PFC pyramidal neuronsCalmodulin kinase II activityKey brain regionsAttention deficit hyperactivity disorderBi-directional regulationDeficit hyperactivity disorderPyramidal neuronsCortical excitabilityDopaminergic inputSynaptic actionsSynaptic transmissionPotent reductionAMPA receptorsKinase II activityStressed animalsMaladaptive changes
2012
Repeated Stress Causes Cognitive Impairment by Suppressing Glutamate Receptor Expression and Function in Prefrontal Cortex
Yuen EY, Wei J, Liu W, Zhong P, Li X, Yan Z. Repeated Stress Causes Cognitive Impairment by Suppressing Glutamate Receptor Expression and Function in Prefrontal Cortex. Neuron 2012, 73: 962-977. PMID: 22405206, PMCID: PMC3302010, DOI: 10.1016/j.neuron.2011.12.033.Peer-Reviewed Original ResearchMeSH Keywords2-Amino-5-phosphonovalerate6-Cyano-7-nitroquinoxaline-2,3-dioneAnalysis of VarianceAnimalsBicucullineCognition DisordersDisease Models, AnimalEndosomal Sorting Complexes Required for TransportExcitatory Amino Acid AntagonistsExcitatory Postsynaptic PotentialsF-Box ProteinsGABA-A Receptor AntagonistsImmunoprecipitationIn Vitro TechniquesMaleNedd4 Ubiquitin Protein LigasesNeuropsychological TestsPrefrontal CortexPyramidal CellsRatsRats, Sprague-DawleyReceptors, GlutamateRecognition, PsychologyRestraint, PhysicalRNA, Small InterferingStress, PsychologicalUbiquitin-Protein LigasesConceptsGlutamate receptor expressionPrefrontal cortexRepeated stressReceptor expressionRecognition memoryCognitive processesTemporal order recognition memoryPFC pyramidal neuronsStress-related mental disordersJuvenile male ratsGlutamatergic responsesGlutamatergic transmissionPyramidal neuronsMale ratsSynaptic transmissionStressed animalsInhibition of proteasomeMaladaptive changesGlucocorticoid receptorCognitive impairmentNR1 subunitMental disordersChronic stressUbiquitin/proteasome-mediated degradationReceptor turnover
2009
Effect of the environment on the dendritic morphology of the rat auditory cortex
Bose M, Muñoz‐llancao P, Roychowdhury S, Nichols J, Jakkamsetti V, Porter B, Byrapureddy R, Salgado H, Kilgard M, Aboitiz F, Dagnino‐Subiabre A, Atzori M. Effect of the environment on the dendritic morphology of the rat auditory cortex. Synapse 2009, 64: 97-110. PMID: 19771593, PMCID: PMC2830877, DOI: 10.1002/syn.20710.Peer-Reviewed Original ResearchConceptsApical dendritic lengthBasal dendritic lengthApical dendritesDendritic lengthAuditory cortexSpine densityBasal dendritesShorter apical dendritesGolgi-Cox staining techniqueLayer-specific patternRat auditory cortexShort basal dendritesPrimary auditory cortexSensory deafnessInduce similar changesInfragranular neuronsLayer 2/3Neocortical plasticityExcitatory synapsesSholl analysisEnvironmental enrichmentStressed animalsGolgi-CoxStress-induced changesEnvironmental manipulationsChronic stress induces dendritic atrophy in the rat medial geniculate nucleus: Effects on auditory conditioning
Dagnino-Subiabre A, Muñoz-Llancao P, Terreros G, Wyneken U, Díaz-Véliz G, Porter B, Kilgard M, Atzori M, Aboitiz F. Chronic stress induces dendritic atrophy in the rat medial geniculate nucleus: Effects on auditory conditioning. Behavioural Brain Research 2009, 203: 88-96. PMID: 19397934, DOI: 10.1016/j.bbr.2009.04.024.Peer-Reviewed Original ResearchMeSH KeywordsAcoustic StimulationAnimalsAuditory PerceptionConditioning, ClassicalDendritesEscape ReactionFearFreezing Reaction, CatalepticGeniculate BodiesMaleNeuronsPhotic StimulationPosterior Thalamic NucleiRandom AllocationRatsRats, Sprague-DawleyReflex, StartleRestraint, PhysicalStress, PsychologicalVisual PerceptionConceptsMedial geniculate nucleusPosterior thalamic nucleusDendritic atrophyUnconditioned fearFear conditioningChronic stressStressed animalsAuditory conditioned stimulusAuditory fear conditioningAvoidance conditioned responseChronic restraint stressCued fear conditioningGeniculate nucleusSprague-Dawley ratsVisual fear conditioningFear conditioning protocolRestraint stressInferior colliculusThalamic nucleiConditioned stimulusConditioning trialsConditioned responseConditioning protocolUnconditioned responseAtrophy
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