2023
Electrical properties of dendritic spines
Zecevic D. Electrical properties of dendritic spines. Biophysical Journal 2023, 122: 4303-4315. PMID: 37837192, PMCID: PMC10698282, DOI: 10.1016/j.bpj.2023.10.008.Peer-Reviewed Original ResearchConceptsDendritic spinesIntracellular calcium concentration changesCortical pyramidal neuronsExcitatory synaptic transmissionCalcium concentration changesBasal dendritesPyramidal neuronsMushroom spinesSpine synapsesSynaptic transmissionBrain slicesVoltage-sensitive dyeNervous systemSpine neckSignificant physiological roleSynaptic signalingTwo-photon uncagingElectrical compartmentsSpineOnly experimental studiesBiochemical compartmentalizationPhysiological roleDifferent preparationsAnatomical structuresAdequate sensitivity
2019
Using holographic illumination to study synaptic signal integration at individual dendritic spines
Weng J, Celis C, Zecevic D. Using holographic illumination to study synaptic signal integration at individual dendritic spines. 2019, 10865: 1086514. DOI: 10.1117/12.2507284.Peer-Reviewed Original ResearchSynaptic signal integrationExcitatory synaptic potentialsDendritic spinesSynaptic potentialsTemporal summationAcute cortical brain slicesIndividual synapsesLayer 5 pyramidal neuronsIndividual excitatory synapsesThin basal dendritesCortical brain slicesVoltage-sensitive dye recordingIndividual dendritic spinesSite of originSensory information processingBasal dendritesPyramidal neuronsExcitatory synapsesBrain slicesRepetitive activationVoltage-sensitive dyeSomatic recordingsSingle synapsesSynaptic signalsIndividual neurons
2017
Protein Tyrosine Phosphatase δ Mediates the Sema3A-Induced Cortical Basal Dendritic Arborization through the Activation of Fyn Tyrosine Kinase
Nakamura F, Okada T, Shishikura M, Uetani N, Taniguchi M, Yagi T, Iwakura Y, Ohshima T, Goshima Y, Strittmatter SM. Protein Tyrosine Phosphatase δ Mediates the Sema3A-Induced Cortical Basal Dendritic Arborization through the Activation of Fyn Tyrosine Kinase. Journal Of Neuroscience 2017, 37: 7125-7139. PMID: 28637841, PMCID: PMC6705738, DOI: 10.1523/jneurosci.2519-16.2017.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCells, CulturedCerebral CortexDendritesEnzyme ActivationFemaleGene Expression Regulation, EnzymologicMaleMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicNeuronal PlasticityProtein-Tyrosine KinasesProto-Oncogene Proteins c-fynReceptor-Like Protein Tyrosine Phosphatases, Class 2Semaphorin-3AConceptsCortical dendritic growthBasal dendritesCultured dorsal root ganglion neuronsCortical layer V neuronsPrimary cultured dorsal root ganglion (DRG) neuronsDorsal root ganglion neuronsWild-type cortical neuronsBasal dendritic arborizationLayer V neuronsAxon guidanceDouble heterozygous mutantsSpecific guidance cuesProtein tyrosine phosphatase δAxon guidance cuesPoor arborizationV neuronsGuidance cuesGanglion neuronsDendritic arborizationCortical neuronsMutant miceSemaphorin 3ASrc kinaseActivation of FynGrowth cone collapse response
2015
Electrical behaviour of dendritic spines as revealed by voltage imaging
Popovic MA, Carnevale N, Rozsa B, Zecevic D. Electrical behaviour of dendritic spines as revealed by voltage imaging. Nature Communications 2015, 6: 8436. PMID: 26436431, PMCID: PMC4594633, DOI: 10.1038/ncomms9436.Peer-Reviewed Original Research
2013
The Angelman Syndrome Protein Ube3a Is Required for Polarized Dendrite Morphogenesis in Pyramidal Neurons
Miao S, Chen R, Ye J, Tan G, Li S, Zhang J, Jiang Y, Xiong Z. The Angelman Syndrome Protein Ube3a Is Required for Polarized Dendrite Morphogenesis in Pyramidal Neurons. Journal Of Neuroscience 2013, 33: 327-333. PMID: 23283345, PMCID: PMC6618628, DOI: 10.1523/jneurosci.2509-12.2013.Peer-Reviewed Original ResearchConceptsPyramidal neuronsApical dendritesLong apical dendritesNeuron dendritic arborsDendrite outgrowthUbiquitin protein ligase E3ANovel pathological mechanismBasal dendritesCorticospinal tractDendritic arborsMouse modelPathological mechanismsMammalian prefrontal cortexExcitatory cellsPrefrontal cortexNeuronsDendrite morphogenesisCellular mechanismsDendritic morphologySelective inhibitionUBE3AMiceDendritesMolecular mechanismsDownregulation
2012
Location-Dependent Excitatory Synaptic Interactions in Pyramidal Neuron Dendrites
Behabadi BF, Polsky A, Jadi M, Schiller J, Mel BW. Location-Dependent Excitatory Synaptic Interactions in Pyramidal Neuron Dendrites. PLOS Computational Biology 2012, 8: e1002599. PMID: 22829759, PMCID: PMC3400572, DOI: 10.1371/journal.pcbi.1002599.Peer-Reviewed Original ResearchConceptsExcitatory synaptic contactsPyramidal neuronsSynaptic contactsSpike thresholdExcitatory synaptic interactionsBasal dendritic arborsNeocortical pyramidal neuronsMore proximal inputsBasal dendritesExcitatory pathwaysDendritic arborsDistal excitationBrain slicesSynaptic projectionsSynaptic interactionsElectrophysiological recordingsProximal inputsResponse modulationFunctional asymmetryNeuronsPeak responseSomaDistal endPN responsesDendritesLocation-Dependent Effects of Inhibition on Local Spiking in Pyramidal Neuron Dendrites
Jadi M, Polsky A, Schiller J, Mel BW. Location-Dependent Effects of Inhibition on Local Spiking in Pyramidal Neuron Dendrites. PLOS Computational Biology 2012, 8: e1002550. PMID: 22719240, PMCID: PMC3375251, DOI: 10.1371/journal.pcbi.1002550.Peer-Reviewed Original ResearchMeSH KeywordsAction Potentialsalpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic AcidAnimalsCalcium SignalingComputational BiologyComputer SimulationDendritesExcitatory Postsynaptic Potentialsgamma-Aminobutyric AcidIn Vitro TechniquesMaleModels, NeurologicalN-MethylaspartatePyramidal CellsRatsRats, WistarSomatosensory CortexConceptsPyramidal neuronsDendritic inhibitionInterneuron typesDendritic spikesLayer 5 pyramidal neuronsSpike thresholdDistal dendritic inhibitionInhibitory interneuron typesSpike initiation zoneDendritic spike thresholdDifferent neural pathwaysBasal dendritesSynaptic contactsNeocortical slicesCortical circuitsDendritic responsesNeural pathwaysSomatic inhibitionLocal spikingSpike generationCortical computationRelative activationInhibitionDetailed compartmental modelNeurons
2009
Effect of the environment on the dendritic morphology of the rat auditory cortex
Bose M, Muñoz‐llancao P, Roychowdhury S, Nichols J, Jakkamsetti V, Porter B, Byrapureddy R, Salgado H, Kilgard M, Aboitiz F, Dagnino‐Subiabre A, Atzori M. Effect of the environment on the dendritic morphology of the rat auditory cortex. Synapse 2009, 64: 97-110. PMID: 19771593, PMCID: PMC2830877, DOI: 10.1002/syn.20710.Peer-Reviewed Original ResearchConceptsApical dendritic lengthBasal dendritic lengthApical dendritesDendritic lengthAuditory cortexSpine densityBasal dendritesShorter apical dendritesGolgi-Cox staining techniqueLayer-specific patternRat auditory cortexShort basal dendritesPrimary auditory cortexSensory deafnessInduce similar changesInfragranular neuronsLayer 2/3Neocortical plasticityExcitatory synapsesSholl analysisEnvironmental enrichmentStressed animalsGolgi-CoxStress-induced changesEnvironmental manipulations
2007
Synaptic Integration of Adult-Generated Olfactory Bulb Granule Cells: Basal Axodendritic Centrifugal Input Precedes Apical Dendrodendritic Local Circuits
Whitman MC, Greer CA. Synaptic Integration of Adult-Generated Olfactory Bulb Granule Cells: Basal Axodendritic Centrifugal Input Precedes Apical Dendrodendritic Local Circuits. Journal Of Neuroscience 2007, 27: 9951-9961. PMID: 17855609, PMCID: PMC6672649, DOI: 10.1523/jneurosci.1633-07.2007.Peer-Reviewed Original ResearchConceptsExternal plexiform layerGranule cell layerAdult-generated granule cellsGranule cellsOlfactory bulbSynaptic integrationLocal circuitsOlfactory bulb granule cellsNew granule cellsSubventricular zone migrateAdult mammalian olfactory bulbMammalian olfactory bulbElaborate dendritic arborsBasal dendritesPostsynaptic markersAxon collateralsSynaptic markersPlexiform layerPeriglomerular cellsDendritic arborsMitral/Spine increasesDendritic spinesNew interneuronsD postinfection
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