2024
Design of a randomized clinical trial of brief couple therapy for PTSD augmented with intranasal oxytocin
Sippel L, Wachsman T, Kelley M, Knopp K, Khalifian C, Maglione J, Glynn S, Macdonald A, Monson C, Flanagan J, Holtzheimer P, Morland L. Design of a randomized clinical trial of brief couple therapy for PTSD augmented with intranasal oxytocin. Contemporary Clinical Trials 2024, 141: 107534. PMID: 38614447, DOI: 10.1016/j.cct.2024.107534.Peer-Reviewed Original ResearchConceptsCognitive-behavioral conjoint therapyImproving posttraumatic stress disorderPosttraumatic stress disorderIntranasal oxytocinConjoint therapyMechanisms of posttraumatic stress disorderRelationship qualityInternational units of oxytocinVA San Diego Healthcare SystemMechanisms of changeCognitive-behavioralStress disorderCouple therapyRelationship satisfactionManual treatmentPreliminary evidenceIntimate relationshipsOxytocinPotential mechanisms of actionVeteransSelf-reported communication skillsPlaceboRandomized clinical trialsCommunication skillsClinical trialsIntranasal Oxytocin Combined With Social Skills Training for Schizophrenia: An Add-on Randomized Controlled Trial
Saporta-Wiesel L, Feldman R, Levi L, Davidson M, Burshtein S, Gur R, Zagoory-Sharon O, Amiaz R, Park J, Davis J, Weiser M. Intranasal Oxytocin Combined With Social Skills Training for Schizophrenia: An Add-on Randomized Controlled Trial. Schizophrenia Bulletin Open 2024, 5: sgae022. PMID: 39502135, PMCID: PMC11535855, DOI: 10.1093/schizbullopen/sgae022.Peer-Reviewed Original ResearchSocial skills trainingSymptoms of schizophreniaSkills trainingSupportive psychotherapyNegative symptoms of schizophreniaTreatment of negative symptomsSocial interactionBaseline to end-of-studyBlunted affectNegative symptomsPANSS scoresIntranasal oxytocinPositive affectSocial dysfunctionSchizophreniaRandomized Controlled TrialsTotal scoreSocial behaviorPost Hoc AnalysisPANSSPsychotherapyOxytocinHigh dose oxytocinAffectEnd-of-study
2018
Oxytocin attenuates trust as a subset of more general reinforcement learning, with altered reward circuit functional connectivity in males
Ide J, Nedic S, Wong K, Strey S, Lawson E, Dickerson B, Wald L, La Camera G, Mujica-Parodi L. Oxytocin attenuates trust as a subset of more general reinforcement learning, with altered reward circuit functional connectivity in males. NeuroImage 2018, 174: 35-43. PMID: 29486321, DOI: 10.1016/j.neuroimage.2018.02.035.Peer-Reviewed Original ResearchConceptsUltra-high field fMRIPre-existing beliefsReinforcement learningBrain encodingGeneral reinforcement learningNeuroeconomic taskIntranasal oxytocinFace of informationField fMRIFeedback learningFMRI activationExperimental paradigmNegative rewardsOrbitofrontal cortexSocial learningReward circuitBehavioral trajectoriesFunctional connectivityConnectivity analysisSocial contextSubjects' behaviorSocial relationshipsBehavioral effectsLearningBayesian expectation
2016
Intranasal Oxytocin Enhances Connectivity in the Neural Circuitry Supporting Social Motivation and Social Perception in Children with Autism
Gordon I, Jack A, Pretzsch CM, Vander Wyk B, Leckman JF, Feldman R, Pelphrey KA. Intranasal Oxytocin Enhances Connectivity in the Neural Circuitry Supporting Social Motivation and Social Perception in Children with Autism. Scientific Reports 2016, 6: 35054. PMID: 27845765, PMCID: PMC5109935, DOI: 10.1038/srep35054.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderIntranasal oxytocinSocial motivationSocial perceptionSocial-emotional informationFunctional magnetic resonance imagingPlacebo-controlled crossover designBiological motionSocial stimuliAngry voicesSocial deficitsSpectrum disorderOT administrationMesolimbic reward pathwayBehavioral treatmentBrain rewardReduced connectivityBrain regionsReward pathwayCortical sitesRewardPerceptionMotivationOxytocinBrain sites
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply