Circulating Plasma Levels of MicroRNA-21 and MicroRNA-221 Are Potential Diagnostic Markers for Primary Intrahepatic Cholangiocarcinoma
Correa-Gallego C, Maddalo D, Doussot A, Kemeny N, Kingham T, Allen P, D’Angelica M, DeMatteo R, Betel D, Klimstra D, Jarnagin W, Ventura A. Circulating Plasma Levels of MicroRNA-21 and MicroRNA-221 Are Potential Diagnostic Markers for Primary Intrahepatic Cholangiocarcinoma. PLOS ONE 2016, 11: e0163699. PMID: 27685844, PMCID: PMC5042503, DOI: 10.1371/journal.pone.0163699.Peer-Reviewed Original ResearchMiR-21MiR-221Plasma miRNAsOverexpression of miR-21Circulating miR-21Circulating plasma miRNAsPlasma expression levelsLevel of microRNA-21MiRNA expressionMicroRNA-21Differentially expressed miRNAsOverexpressed miRNAsUpregulated miRNAsCohort of patientsIntrahepatic cholangiocarcinomaMicroRNA-221Healthy controlsMiRNAsMiRNA expression dataNon-neoplastic liver parenchymaDiscriminatory abilityPrimary intrahepatic cholangiocarcinomaIntrahepatic cholangiocarcinoma patientsCirculating plasma levelsPotential diagnostic markers
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