2022
Role of Structural Modifications of Drug Candidates to Enhance Metabolic Stability
Nassar A. Role of Structural Modifications of Drug Candidates to Enhance Metabolic Stability. 2022, 303-322. DOI: 10.1002/9781119851042.ch9.Peer-Reviewed Original ResearchDrug candidatesStructural modificationsMetabolic stabilityDrug discovery processADME propertiesMetabolite characterizationDrug designDrug discoveryBalance of propertiesToxicity relationshipsExcretion studiesMetabolic instabilityDiscovery processHuman patientsStabilityPropertiesSuccess rateModificationDrugsCandidatesCharacterizationAbsorptionPatients
2019
Absorption shifts of diastereotopically ligated chlorophyll dimers of photosystem I
Suomivuori C, Fliegl H, Starikov E, Balaban T, Kaila V, Sundholm D. Absorption shifts of diastereotopically ligated chlorophyll dimers of photosystem I. Physical Chemistry Chemical Physics 2019, 21: 6851-6858. PMID: 30874282, DOI: 10.1039/c9cp00616h.Peer-Reviewed Original ResearchConceptsTime-dependent density functional theoryReduced virtual spaceChl dimerInitio calculationsApproximate second-order coupled clusterAbsorption shiftSecond-order coupled clusterCorrelated ab initio calculationsRange-separated density functionalsAlgebraic-diagrammatic constructionExcited-state propertiesNatural photosynthetic systemsAb initio calculationsDensity functional theoryPhotosynthetic systemsMolecular starting pointsChl ringExciton couplingFunctional theoryReaction centerAcid moietyEnergy conversionDimerHistidine residuesAbsorption
2013
Bone marrow absorption and retention properties of engineered scaffolds with micro-channels and nano-pores for tissue engineering: A proof of concept
Oh D, Kim Y, Ganbat D, Han M, Lim P, Back J, Lee F, Tawfeek H. Bone marrow absorption and retention properties of engineered scaffolds with micro-channels and nano-pores for tissue engineering: A proof of concept. Ceramics International 2013, 39: 8401-8410. DOI: 10.1016/j.ceramint.2013.04.021.Peer-Reviewed Original ResearchCapillary actionNano-sized poresMicro-sized channelsNative trabecular boneHydroxyapatite-based scaffoldProof of conceptTissue engineeringCoating methodHuman trabecular boneSurface areaEntire scaffoldOverall porosityRetention propertiesTrabecular boneScaffoldsDesign softwareNovel scaffoldCells ingressTrabecular networkInternal structurePorosityAbsorptionIngressEngineeringCombinatorial effects
2012
Questioning the questions that have been asked about the infant brain using near-infrared spectroscopy
Aslin RN. Questioning the questions that have been asked about the infant brain using near-infrared spectroscopy. Cognitive Neuropsychology 2012, 29: 7-33. PMID: 22329690, PMCID: PMC3461095, DOI: 10.1080/02643294.2012.654773.Peer-Reviewed Original Research
2010
Biomimetic Isotropic Nanostructures for Structural Coloration
Forster JD, Noh H, Liew SF, Saranathan V, Schreck CF, Yang L, Park J, Prum RO, Mochrie SG, O'Hern CS, Cao H, Dufresne ER. Biomimetic Isotropic Nanostructures for Structural Coloration. Advanced Materials 2010, 22: 2939-2944. PMID: 20414884, DOI: 10.1002/adma.200903693.Peer-Reviewed Original ResearchStructural Modifications of Drug Candidates: How Useful Are They in Improving Metabolic Stability of New Drugs? Part I: Enhancing Metabolic Stability
Nassar A. Structural Modifications of Drug Candidates: How Useful Are They in Improving Metabolic Stability of New Drugs? Part I: Enhancing Metabolic Stability. 2010, 1-16. DOI: 10.1002/9780470571224.pse109.Peer-Reviewed Original Research
2009
Imaging Membrane Potential with Voltage-Sensitive Dyes
Vucinic D, Kosmidis E, Falk C, Cohen L, Loew L, Djurisic M, Zecevic D. Imaging Membrane Potential with Voltage-Sensitive Dyes. 2009, 132-160. DOI: 10.1093/oso/9780195150445.003.0006.Peer-Reviewed Original ResearchMembrane-bound dyeOptical signalSecond harmonic generationVoltage-sensitive dyeDifferent optical propertiesHarmonic generationOptical measurementsOptical propertiesRaman absorptionOptical recordingRise timeSimultaneous measurementAbsorptionFigure 6.1BirefringenceFluorescenceMeasurementsDichroismDyeMolecular probesSignalsSquidKinds of results
2004
Improvingthe decision-making process in structural modification of drug candidates: reducing toxicity
Nassar A, Kamel A, Clarimont C. Improvingthe decision-making process in structural modification of drug candidates: reducing toxicity. Drug Discovery Today 2004, 9: 1055-1064. PMID: 15582794, DOI: 10.1016/s1359-6446(04)03297-0.Peer-Reviewed Original ResearchConceptsStructural modification of drug candidatesAdvancement of drug candidatesReactive intermediate formationGuided drug designDrug candidatesIntermediate formationBalance of propertiesLead compoundsDrug designStructural modificationsDrug discoveryReactive metabolitesDecision-making processReactionRadiolabeled reagentsDrug reactionsIdiosyncratic drug reactionsReagentsCompoundsAdverse drug reactionsADMEAbsorptionHuman patientsReduced toxicitySubstructureChapter 8 Prodrugs and Drug Delivery Systems
Silverman R. Chapter 8 Prodrugs and Drug Delivery Systems. 2004, 497-557. DOI: 10.1016/b978-0-08-051337-9.50013-4.Peer-Reviewed Original ResearchProdrug-to-drug conversionInactive compoundsActive drugBioprecursor prodrugsDrug designProdrug moleculesTransformation compoundsCompoundsDrug candidatesMolecular modificationsParent drugPhysicochemical propertiesMechanism of drug activityAbsorptionPharmacokinetic propertiesActivity of drugsPharmacodynamic propertiesTargeting of drugsConversion
2003
[20] Optical monitoring of neural activity using voltage-sensitive dyes
Djurisic M, Zochowski M, Wachowiak M, Falk CX, Cohen LB, Zecevic D. [20] Optical monitoring of neural activity using voltage-sensitive dyes. Methods In Enzymology 2003, 361: 423-451. PMID: 12624923, DOI: 10.1016/s0076-6879(03)61022-0.Peer-Reviewed Original ResearchConceptsOptical monitoringSecond harmonic generationVoltage-sensitive dyeDifferent optical propertiesMembrane-bound dyeHarmonic generationOptical propertiesOptical measurementsFluorescence resonance energy transferRaman absorptionEnergy transferResonance energy transferSimultaneous measurementAbsorptionBirefringenceMeasurementsDichroismDyeMolecular probesPopulation signalsFluorescenceProbe
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