2024
Characterization of Eddy-Currents Associated with Multi-Coil B0 Field Control in an Accessible Head-Only Scanner
Theilenberg S, Ismail R, Froelich T, DeLabarre L, Nixon T, de Graaf R, Garwood M, Juchem C. Characterization of Eddy-Currents Associated with Multi-Coil B0 Field Control in an Accessible Head-Only Scanner. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2024 DOI: 10.58530/2024/3932.Peer-Reviewed Original Research
2022
Exploring the genetic overlap between twelve psychiatric disorders
Romero C, Werme J, Jansen P, Gelernter J, Stein M, Levey D, Polimanti R, de Leeuw C, Posthuma D, Nagel M, van der Sluis S. Exploring the genetic overlap between twelve psychiatric disorders. Nature Genetics 2022, 54: 1795-1802. PMID: 36471075, DOI: 10.1038/s41588-022-01245-2.Peer-Reviewed Original ResearchConceptsSingle nucleotide polymorphismsPleiotropic single nucleotide polymorphismsPositive genetic correlationStringent P-value thresholdGenetic architectureGenomic regionsGenetic covarianceBiological processesBiological pathwaysMolecular characterizationObserved phenotypicGenetic correlationsGenetic overlapBiological characterizationBiological mechanismsP-value thresholdOnly annotationGenesPleiotropicPairwise comparisonsPhenotypicPathwayAnnotationPolymorphismCharacterizationRole of Structural Modifications of Drug Candidates to Enhance Metabolic Stability
Nassar A. Role of Structural Modifications of Drug Candidates to Enhance Metabolic Stability. 2022, 303-322. DOI: 10.1002/9781119851042.ch9.Peer-Reviewed Original ResearchDrug candidatesStructural modificationsMetabolic stabilityDrug discovery processADME propertiesMetabolite characterizationDrug designDrug discoveryBalance of propertiesToxicity relationshipsExcretion studiesMetabolic instabilityDiscovery processHuman patientsStabilityPropertiesSuccess rateModificationDrugsCandidatesCharacterizationAbsorptionPatients
2021
Forging O–O Bonds
Cody C, Brudvig G. Forging O–O Bonds. Joule 2021, 5: 1923-1925. DOI: 10.1016/j.joule.2021.07.013.Peer-Reviewed Original Research
2020
Rational Design of Bioavailable Photosensitizers for Manipulation and Imaging of Biological Systems
Binns TC, Ayala AX, Grimm JB, Tkachuk AN, Castillon GA, Phan S, Zhang L, Brown TA, Liu Z, Adams SR, Ellisman MH, Koyama M, Lavis LD. Rational Design of Bioavailable Photosensitizers for Manipulation and Imaging of Biological Systems. Cell Chemical Biology 2020, 27: 1063-1072.e7. PMID: 32698018, PMCID: PMC7483975, DOI: 10.1016/j.chembiol.2020.07.001.Peer-Reviewed Original ResearchConceptsBiological systemsChemical toolsRational designChemical reactionsPhotosensitizerElectron microscopyChromophore-assisted light inactivationNumerous biological experimentsHigh-resolution imagingPowerful methodPhotopolymerizationReactive oxygen speciesRhodamineOxygen speciesSynthesisTargeted destructionReactionBiological experimentsBroad rangeMicroscopyCharacterizationCell ablationDiaminobenzidineSynthesis of organometallic pincer-supported cobalt(II) complexes
Townsend T, Bernskoetter W, Brudvig G, Hazari N, Lant H, Mercado B. Synthesis of organometallic pincer-supported cobalt(II) complexes. Polyhedron 2020, 177: 114308. DOI: 10.1016/j.poly.2019.114308.Peer-Reviewed Original Research
2017
Synthesis and Characterization of Iridium(V) Coordination Complexes With an N,O‐Donor Organic Ligand
Sharninghausen L, Sinha S, Shopov D, Mercado B, Balcells D, Brudvig G, Crabtree R. Synthesis and Characterization of Iridium(V) Coordination Complexes With an N,O‐Donor Organic Ligand. Angewandte Chemie 2017, 129: 13227-13231. DOI: 10.1002/ange.201707593.Peer-Reviewed Original ResearchCoordination complexesO-donor organic ligandsMononuclear coordination complexesO-donor environmentMetal-centered oxidationX-ray crystallographyOrganic ligandsDonor strengthAlkoxide groupsDFT calculationsD orbitalsUnprecedented stabilityComplexesLigandsOxidationIR-VIsomersXPSCrystallographyV complexSynthesisCharacterizationStabilityCalculationsDegradationIdentification and Partial Structural Characterization of Mass Isolated Valsartan and Its Metabolite with Messenger Tagging Vibrational Spectroscopy
Gorlova O, Colvin SM, Brathwaite A, Menges FS, Craig SM, Miller SJ, Johnson MA. Identification and Partial Structural Characterization of Mass Isolated Valsartan and Its Metabolite with Messenger Tagging Vibrational Spectroscopy. Journal Of The American Society For Mass Spectrometry 2017, 28: 2414-2422. PMID: 28801884, DOI: 10.1007/s13361-017-1767-z.Peer-Reviewed Original ResearchVibrational spectroscopyStructural characterizationRole of conformersOH stretching fundamentalsPartial structural characterizationStructural isomersIsomeric formsTarget ionsMass spectrometryN2 moleculesDrug valsartanRf ion trapIR absorptionIon trapFingerprint regionK ionsIon approachSpectroscopyIonsIsomersCharacterizationConformersRecent advancesSpectrometryOHVisualization and characterization of individual type III protein secretion machines in live bacteria
Zhang Y, Lara-Tejero M, Bewersdorf J, Galán JE. Visualization and characterization of individual type III protein secretion machines in live bacteria. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: 6098-6103. PMID: 28533372, PMCID: PMC5468683, DOI: 10.1073/pnas.1705823114.Peer-Reviewed Original ResearchConceptsProtein secretion machinesSecretion machineType III secretion machinesLive bacteriaEukaryotic cellsEffector proteinsMolecular machinesSubcellular distributionSuperresolution microscopyBacteriaMajor insightsResolution gapDetailed viewAssemblyMutantsProteinNanomachinesCharacterizationCellsSpatial distributionIsolation
2016
Phytochemical screening of Saye, a traditional herbal remedy for malaria
Da O, Coulibaly M, Ouédraogo J, Yaro B, Yerbanga R, Kini F, Koama B, Dakuyo Z, Nikiema J, Ouédraogo G, Matsabisa, Ouédraogo J. Phytochemical screening of Saye, a traditional herbal remedy for malaria. International Journal Of Biological And Chemical Sciences 2016, 9: 2940-2946. DOI: 10.4314/ijbcs.v9i6.33.Peer-Reviewed Original ResearchSpecific chemical reagentsHigh-performance liquid chromatographyCharacterization of phytoconstituentsPerformance liquid chromatographyThin-layer chromatographyChemical reagentsLiquid chromatographyChemical profilesOrganic extractsLayer chromatographyChromatographyHPLC analysisReagentsAnthraquinoneWater extractMixtureCassia alataCharacterizationCochlospermum planchoniiExtractTriterpenesWaterPhytoconstituentsHigh-resolution mass spectrometry of small molecules bound to membrane proteins
Gault J, Donlan JA, Liko I, Hopper JT, Gupta K, Housden NG, Struwe WB, Marty MT, Mize T, Bechara C, Zhu Y, Wu B, Kleanthous C, Belov M, Damoc E, Makarov A, Robinson CV. High-resolution mass spectrometry of small molecules bound to membrane proteins. Nature Methods 2016, 13: 333-336. PMID: 26901650, PMCID: PMC4856209, DOI: 10.1038/nmeth.3771.Peer-Reviewed Original Research
2013
Rhodium(III)-Catalyzed Indazole Synthesis by C–H Bond Functionalization and Cyclative Capture
Lian Y, Bergman RG, Lavis LD, Ellman JA. Rhodium(III)-Catalyzed Indazole Synthesis by C–H Bond Functionalization and Cyclative Capture. Journal Of The American Chemical Society 2013, 135: 7122-7125. PMID: 23642256, PMCID: PMC3656829, DOI: 10.1021/ja402761p.Peer-Reviewed Original ResearchConceptsH bond functionalizationInitial spectroscopic characterizationH bond additionBond functionalizationSpectroscopic characterizationBond additionIndazole productsAryl groupsRegioselective couplingN-substitutionUnsymmetrical azobenzenesAzobenzeneOne-stepIndazoleNew classSynthesisFunctionalizationAldehydesFluorophoresPreparationCharacterizationProducts
2012
SU‐E‐T‐92: on the Use of High‐Sensitivity Thermoluminescent Dosimeters (TLDs) for Dosimetric Characterization of Low‐Energy Brachytherapy Sources
Chen Z, Bongiorni P, Donahue W, Hearn R, Rodgers J, Nath R. SU‐E‐T‐92: on the Use of High‐Sensitivity Thermoluminescent Dosimeters (TLDs) for Dosimetric Characterization of Low‐Energy Brachytherapy Sources. Medical Physics 2012, 39: 3723-3723. PMID: 28517162, DOI: 10.1118/1.4735149.Peer-Reviewed Original ResearchRoom temperatureTLD-100HIrradiation timeThermal reservoirReservoir systemLow-energy brachytherapy sourcesDosimetric characterizationDosimetry characterizationAnnealingSource characterizationTLD-100Solid phantomHeatingTemperatureC heatingTest casesReservoirBrachytherapy sourcesWater equivalent solid phantomCharacterizationCs-137 irradiator
2011
Synthesis and Characterization of Self-Assembled DNA Nanostructures
Lin C, Ke Y, Chhabra R, Sharma J, Liu Y, Yan H. Synthesis and Characterization of Self-Assembled DNA Nanostructures. Methods In Molecular Biology 2011, 749: 1-11. PMID: 21674361, DOI: 10.1007/978-1-61779-142-0_1.ChaptersConceptsDNA nanostructuresDNA nanotechnologySelf-assembled DNA nanostructuresSuch nanoscale objectsStructural DNA nanotechnologyCharacterization of SelfDNA-based nanodevicesExcellent yieldsNanoscale objectsNanostructuresArtificial nanostructuresMolecular speciesBuilding blocksNanotechnologyFast evolvementMain building blocksNanoarchitecturesLarge varietySynthesisMaterialsNanodevicesPreparationCharacterizationBuilding materialsYieldAn Iridium(IV) Species, [Cp*Ir(NHC)Cl]+, Related to a Water-Oxidation Catalyst
Brewster T, Blakemore J, Schley N, Incarvito C, Hazari N, Brudvig G, Crabtree R. An Iridium(IV) Species, [Cp*Ir(NHC)Cl]+, Related to a Water-Oxidation Catalyst. Organometallics 2011, 30: 965-973. DOI: 10.1021/om101016s.Peer-Reviewed Original ResearchWater oxidation catalystsOne-electron stepsX-ray crystallographyWingtip groupsElectrochemical characterizationLigand environmentElectrochemical behaviorOxidation stateEPR spectroscopyNew compoundsCatalystRhombic symmetryCompoundsΚ2 CC donorsPrecatalystNHCChelatesCrystallographySpectroscopyLigandsCatalyticPrecursorsCharacterizationWater
2008
Structural Modifications of Drug Candidates: How Useful Are They in Improving Metabolic Stability of New Drugs? Part I: Enhancing Metabolic Stability
Nassar A. Structural Modifications of Drug Candidates: How Useful Are They in Improving Metabolic Stability of New Drugs? Part I: Enhancing Metabolic Stability. 2008, 253-268. DOI: 10.1002/9780470439265.ch10.Peer-Reviewed Original Research
2007
Characterization and Optimization of Selective, Nonpeptidic Inhibitors of Cathepsin S with an Unprecedented Binding Mode †
Inagaki H, Tsuruoka H, Hornsby M, Lesley SA, Spraggon G, Ellman JA. Characterization and Optimization of Selective, Nonpeptidic Inhibitors of Cathepsin S with an Unprecedented Binding Mode †. Journal Of Medicinal Chemistry 2007, 50: 2693-2699. PMID: 17469812, DOI: 10.1021/jm070111+.Peer-Reviewed Original ResearchConceptsUnprecedented binding modePotent cathepsin S inhibitorsBinding modesX-ray structureLow molecular weightCathepsin S inhibitorsNonpeptidic inhibitorsK. CharacterizationMolecular weightS inhibitorsAldehyde inhibitorsFragment identificationCleavage efficiencyCathepsin SInhibitor 2SubstrateSelectivityScreening methodStructureKi valuesComplexesCathepsin BConversionCharacterizationSelective
2002
Enantioselective Oxidation of Di-tert-Butyl Disulfide with a Vanadium Catalyst: Progress toward Mechanism Elucidation †
Blum SA, Bergman RG, Ellman JA. Enantioselective Oxidation of Di-tert-Butyl Disulfide with a Vanadium Catalyst: Progress toward Mechanism Elucidation †. The Journal Of Organic Chemistry 2002, 68: 150-155. PMID: 12515473, DOI: 10.1021/jo0205560.Peer-Reviewed Original ResearchSolvent effectsDi-tertChiral Schiff base ligandsButyl disulfideSchiff base ligandDramatic solvent effectVanadium catalystsNMR spectroscopyCatalyst precursorsEnantioselective oxidationReaction enantioselectivityOxidation pathwayMechanism elucidationEnantioselectivityFull characterizationLigandsOxidationDisulfideCatalystSpectroscopyThiosulfinatesReactionPrecursorsElucidationCharacterizationHydrothermal synthesis and characterization of nanorods “LixV2−δO4−δ·H2O”
Zhang H, Gui Z, Fan R, Chen X. Hydrothermal synthesis and characterization of nanorods “LixV2−δO4−δ·H2O”. Inorganic Chemistry Communications 2002, 5: 399-402. DOI: 10.1016/s1387-7003(02)00413-6.Peer-Reviewed Original ResearchX-ray photoelectron spectroscopyX-ray diffractionTransmission electron microscopyCharacterization of nanorodsOne-dimensional nanorodsHydrothermal synthesisHydrazine monohydratePhotoelectron spectroscopyAlkaline conditionsMolecular coordinationNanorodsElectron microscopyAssembly mechanismV2O5SpectroscopyDiffractionMonohydrateSynthesisMicroscopyCharacterizationCoordination
1999
Affinity interaction of hydroxypyruvate reductase from Methylophilus spp. with Cibacron blue F3GA-derived poly(HEMA EGDMA) microspheres: partial purification and characterization
Arica M, Halıcıgil C, Alaeddinoğlu G, Denizli A. Affinity interaction of hydroxypyruvate reductase from Methylophilus spp. with Cibacron blue F3GA-derived poly(HEMA EGDMA) microspheres: partial purification and characterization. Process Biochemistry 1999, 34: 375-381. DOI: 10.1016/s0032-9592(98)00104-6.Peer-Reviewed Original ResearchCibacron Blue F3GABiomimetic dyesAdsorption mediumDimer structureMolecular massNADH solutionAffinity interactionHydroxypyruvate reductaseMicrospheresAbsorption capacityMethylophilus sppSDS-polyacrylamide gelsPartial purificationOptimal pHReductasePolyacrylamideDyeMaximum enzyme activityGelKm valuesPurificationMMPHEnzymeCharacterization
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply