2025
Using geospatial analysis to describe the association between active tick surveillance data and clinical cases of anaplasmosis in Connecticut
Desiato J, Chan G, Palmeri M, Cantoni J, Cozens D, Linske M, Brackney D, Stafford K, Banach D. Using geospatial analysis to describe the association between active tick surveillance data and clinical cases of anaplasmosis in Connecticut. Journal Of Medical Entomology 2025, tjaf055. PMID: 40341955, DOI: 10.1093/jme/tjaf055.Peer-Reviewed Original ResearchDepartment of Public HealthConnecticut Department of Public HealthCases of anaplasmosisClinical cases of anaplasmosisIncidence ratePublic healthSurveillance dataPublic health interventionsPotential associationI. scapularisHealth interventionsTick surveillance dataConnecticut Agricultural Experiment StationIdentified geographic areasAgricultural Experiment StationEvaluate potential associationsIxodes scapularis ticksBacterium Anaplasma phagocytophilumPrevalence dataActive tick surveillanceClinical casesQuesting I. scapularisSpearman rank correlationIncreased riskAnaplasma phagocytophilum
2024
Salp14 epitope-based mRNA vaccination induces early recognition of a tick bite
Cui Y, Cibichakravarthy B, Tang X, Alameh M, Dwivedi G, Weissman D, Fikrig E. Salp14 epitope-based mRNA vaccination induces early recognition of a tick bite. Vaccine 2024, 42: 126304. PMID: 39236403, PMCID: PMC11416896, DOI: 10.1016/j.vaccine.2024.126304.Peer-Reviewed Original ResearchTick bite siteGuinea pigsMRNA-LNPMRNA vaccinesBite siteImmunized guinea pigsTiters of IgGIxodes scapularis ticksDevelopment of erythemaLipid nanoparticlesSkin of guinea pigsI. scapularisTicksErythemaHistamine activityPigsTick bitesCarboxyl terminusRepeated exposureExposure of animalsAmino acidsSalivary proteinsVaccineMRNAGuineaBacterial reprogramming of tick metabolism impacts vector fitness and susceptibility to infection
Samaddar S, Rolandelli A, O’Neal A, Laukaitis-Yousey H, Marnin L, Singh N, Wang X, Butler L, Rangghran P, Kitsou C, Cabrera Paz F, Valencia L, R. Ferraz C, Munderloh U, Khoo B, Cull B, Rosche K, Shaw D, Oliver J, Narasimhan S, Fikrig E, Pal U, Fiskum G, Polster B, Pedra J. Bacterial reprogramming of tick metabolism impacts vector fitness and susceptibility to infection. Nature Microbiology 2024, 9: 2278-2291. PMID: 38997520, PMCID: PMC11926704, DOI: 10.1038/s41564-024-01756-0.Peer-Reviewed Original ResearchMetabolic reprogrammingInfection of tick cellsInvestigate metabolic reprogrammingTick cellsLyme disease spirochete Borrelia burgdorferiSusceptibility to infectionArthropod-borne pathogensMetabolomics approachRickettsia buchneriHuman pathogensMetabolite allocationDiminished survivalBacterium Anaplasma phagocytophilumSpirochete Borrelia burgdorferiAcid metabolismA. phagocytophilum infectionInterspecies relationshipsElevated levelsInfectionFeeding impairmentHuman granulocytic anaplasmosisMetabolic responseArthropod vectorsI. scapularisPathogens
2023
Metabolomic changes associated with acquired resistance to Ixodes scapularis
Cui Y, Matias J, Tang X, Cibichakravarthy B, DePonte K, Wu M, Fikrig E. Metabolomic changes associated with acquired resistance to Ixodes scapularis. Ticks And Tick-borne Diseases 2023, 15: 102279. PMID: 37972499, DOI: 10.1016/j.ttbdis.2023.102279.Peer-Reviewed Original ResearchGuinea pigsHydroxyphenyllactic acidMetabolome of serumGroups of miceTyrosine metabolic pathwayTick biteImmune responseControl animalsIxodes scapularisTick salivaI. scapularisMiceInduction of componentsMetabolomic changesMortalityNitisinoneMolecular mechanismsAnimalsMetabolism pathwaysTyrosine degradationPigsTyrosine metabolism pathwayMetabolic pathwaysScapularisMetabolome
2022
Identification of novel conserved Ixodes vaccine candidates; a promising role for non-secreted salivary gland proteins
Trentelman J, de Vogel F, Colstrup E, Sima R, Coumou J, Koetsveld J, Klouwens M, Nayak A, Ersoz J, Barriales D, Tomás-Cortázar J, Narasimhan S, Hajdusek O, Anguita J, Hovius J. Identification of novel conserved Ixodes vaccine candidates; a promising role for non-secreted salivary gland proteins. Vaccine 2022, 40: 7593-7603. PMID: 36357287, DOI: 10.1016/j.vaccine.2022.10.032.Peer-Reviewed Original ResearchConceptsTick salivary gland proteinsAnti-tick vaccinesTick immunityVaccine candidatesSalivary gland proteinsLyme borreliosisNymphal I. ricinusExperimental Lyme borreliosisImmune animalsVaccination studiesTick feedingI. ricinusTick attachmentNymphal ticksPathogen transmissionGuinea pigsIxodes scapularisI. scapularisGland proteinsVaccineCausative agentImmunityMain vectorIdentification of novelPromising roleImmunization of guinea pigs with cement extract induces resistance against Ixodes scapularis ticks
Lynn GE, Černý J, Kurokawa C, Diktaş H, Matias J, Sajid A, Arora G, DePonte K, Narasimhan S, Fikrig E. Immunization of guinea pigs with cement extract induces resistance against Ixodes scapularis ticks. Ticks And Tick-borne Diseases 2022, 13: 102017. PMID: 35963188, DOI: 10.1016/j.ttbdis.2022.102017.Peer-Reviewed Original ResearchTick salivaAnti-tick vaccinesTick-host interfaceSpecific protective antigensTick engorgement weightIxodes scapularis ticksTick speciesTick feedingEngorgement weightFeeding ticksHost resistanceTickborne pathogensDisease agentsAnimal hostsIxodes scapularisFemale I. scapularisI. scapularisScapularis ticksTicksImportant vectorTick detachmentPrimary vectorMidgut extractsProtective antigenHematophagous parasites
2019
Vertical transmission rates of Borrelia miyamotoi in Ixodes scapularis collected from white-tailed deer
Han S, Lubelczyk C, Hickling GJ, Belperron AA, Bockenstedt LK, Tsao JI. Vertical transmission rates of Borrelia miyamotoi in Ixodes scapularis collected from white-tailed deer. Ticks And Tick-borne Diseases 2019, 10: 682-689. PMID: 30846418, PMCID: PMC6551370, DOI: 10.1016/j.ttbdis.2019.02.014.Peer-Reviewed Original ResearchConceptsVertical transmission rateB. miyamotoiBorrelia miyamotoiBorrelia miyamotoi diseaseHunter-harvested white-tailed deerTransovarial transmission ratesInfected female ticksMiyamotoi infectionB. burgdorferi sensu strictoBurgdorferi sensu strictoInfection prevalenceI. scapularisHuman hostIxodes ricinus complexMiyamotoiLarval I. scapularisWhite-tailed deerLyme borreliaeFever spirochetesFurther investigation
2018
Host-specific expression of Ixodes scapularis salivary genes
Narasimhan S, Booth CJ, DePonte K, Wu MJ, Liang X, Mohanty S, Kantor F, Fikrig E. Host-specific expression of Ixodes scapularis salivary genes. Ticks And Tick-borne Diseases 2018, 10: 386-397. PMID: 30545615, DOI: 10.1016/j.ttbdis.2018.12.001.Peer-Reviewed Original ResearchConceptsVector-host interactionsTick infestationI. scapularisReservoir hostsNon-reservoir hostsHost-specific expressionRodent reservoir hostsInfected ticksPathogen transmissionZoonotic cycleSalivary genesIxodes scapularisTicksNatural hostScapularisInfestationTick biteLyme diseaseBorrelia burgdorferiLarval stagesPathogensHostPeromyscus leucopusStrong immune responseSalivary transcriptome
2009
Passage through Ixodes scapularis Ticks Enhances the Virulence of a Weakly Pathogenic Isolate of Borrelia burgdorferi
Adusumilli S, Booth CJ, Anguita J, Fikrig E. Passage through Ixodes scapularis Ticks Enhances the Virulence of a Weakly Pathogenic Isolate of Borrelia burgdorferi. Infection And Immunity 2009, 78: 138-144. PMID: 19822652, PMCID: PMC2798202, DOI: 10.1128/iai.00470-09.Peer-Reviewed Original ResearchConceptsIxodes scapularis ticksCommon tick-borne illnessScapularis ticksTick-borne illnessB. burgdorferi sensu strictoC3H miceBurgdorferi sensu strictoLyme diseaseMiceHigh expression levelsBorrelia burgdorferiB. burgdorferiTick engorgementExpression levelsSpirochetesDiseaseArray analysisSyringe inoculationBurgdorferiPathogenic isolatesIsolatesI. scapularisArthritisVirulencePathogenesis
2007
Role of Outer Surface Protein D in the Borrelia burgdorferi Life Cycle
Li X, Neelakanta G, Liu X, Beck DS, Kantor FS, Fish D, Anderson JF, Fikrig E. Role of Outer Surface Protein D in the Borrelia burgdorferi Life Cycle. Infection And Immunity 2007, 75: 4237-4244. PMID: 17620358, PMCID: PMC1951184, DOI: 10.1128/iai.00632-07.Peer-Reviewed Original ResearchConceptsB. burgdorferiSecond blood mealMurine modelSpirochete transmissionB. burgdorferi persistenceLyme borreliosisMiceB. burgdorferi strainsProtein DI. scapularisTick gutBlood mealBurgdorferi strainsSpirochete life cycleBurgdorferiGut extractsIxodes scapularisB. burgdorferi infectivityThreefold decreaseHost-specific signalsScapularisTicksBorreliosisA Tick Antioxidant Facilitates the Lyme Disease Agent's Successful Migration from the Mammalian Host to the Arthropod Vector
Narasimhan S, Sukumaran B, Bozdogan U, Thomas V, Liang X, DePonte K, Marcantonio N, Koski RA, Anderson JF, Kantor F, Fikrig E. A Tick Antioxidant Facilitates the Lyme Disease Agent's Successful Migration from the Mammalian Host to the Arthropod Vector. Cell Host & Microbe 2007, 2: 7-18. PMID: 18005713, PMCID: PMC2699493, DOI: 10.1016/j.chom.2007.06.001.Peer-Reviewed Original ResearchConceptsMammalian hostsComplex feeding sitesLyme disease agent Borrelia burgdorferiSuccessful migrationMammalian responseTick Ixodes scapularisTick salivary glandsReactive oxygen speciesFeeding sitesArthropod vectorsTick proteinsBurgdorferi-infected miceOxygen speciesEfficient vectorCritical roleSpirochete acquisitionIxodes scapularisB. burgdorferiPathogensHostBorrelia burgdorferiI. scapularisInflammatory cellsImmune cellsSurvival advantage
2006
Disruption of the salivary protein 14 in Ixodes scapularis nymphs and impact on pathogen acquisition.
PEDRA JH, Narasimhan S, Deponte K, Marcantonio N, KANTOR FS, Fikrig E. Disruption of the salivary protein 14 in Ixodes scapularis nymphs and impact on pathogen acquisition. American Journal Of Tropical Medicine And Hygiene 2006, 75: 677-82. PMID: 17038693, DOI: 10.4269/ajtmh.2006.75.677.Peer-Reviewed Original ResearchConceptsScapularis nymphsProtein 14Adult Ixodes scapularisIxodes scapularis nymphsI. scapularisBorrelia burgdorferiTick feedingI. scapularis nymphsB. burgdorferiFamily expressionEngorgement weightTick weightPhysiological rolePathogen acquisitionBurgdorferiIxodes scapularisRNA interferenceExpressionDifferent mechanismsFeedingScapularis
1999
Temporal Relation between Ixodes scapularis Abundance and Risk for Lyme Disease Associated with Erythema Migrans
Falco R, McKenna D, Daniels T, Nadelman R, Nowakowski J, Fish D, Wormser G. Temporal Relation between Ixodes scapularis Abundance and Risk for Lyme Disease Associated with Erythema Migrans. American Journal Of Epidemiology 1999, 149: 771-776. PMID: 10206627, DOI: 10.1093/oxfordjournals.aje.a009886.Peer-Reviewed Original ResearchConceptsErythema migransLyme diseaseWestchester County Medical CenterLyme Disease AssociatedEarly Lyme diseaseCounty Medical CenterDisease prevention effortsYears of ageSuccessful prevention programsAdult ticksDisease AssociatedPrevention criteriaMedical CenterPatientsPrevention programsDisease controlPrevention effortsCase numbersI. scapularisDiseaseAdult I. scapularisEM casesEM incidenceAnnual numberMigransComparative Vector Competence of Dermacentor variabilis and Ixodes scapularis (Acari: Ixodidae) for the Agent of Human Granulocytic Ehrlichiosis
Vignes F, Levin M, Fish D. Comparative Vector Competence of Dermacentor variabilis and Ixodes scapularis (Acari: Ixodidae) for the Agent of Human Granulocytic Ehrlichiosis. Journal Of Medical Entomology 1999, 36: 182-185. PMID: 10083755, DOI: 10.1093/jmedent/36.2.182.Peer-Reviewed Original ResearchConceptsAgent of HGEHuman granulocytic ehrlichiosisPolymerase chain reactionD. variabilis nymphsGranulocytic ehrlichiosisI. scapularis nymphsEvidence of transmissionVector competenceScapularis nymphsI. scapularisLeucopus miceD. variabilis larvaeMiceDermacentor variabilisComparative vector competenceRepletionChain reactionCompetent vectorsD. variabilisWhite-footed miceTrialsEhrlichiosisAgentsIxodes scapularisIxodes scapularis Say
1998
Density-dependent factors regulating feeding success of Ixodes scapularis larvae (Acari: Ixodidae).
Levin M, Fish D. Density-dependent factors regulating feeding success of Ixodes scapularis larvae (Acari: Ixodidae). Journal Of Parasitology 1998, 84: 36-43. PMID: 9488335, DOI: 10.2307/3284526.Peer-Reviewed Original ResearchConceptsMice fed 2Larval Ixodes scapularis ticksIxodes scapularis ticksReplete larvaeIxodes scapularis larvaeUnattached ticksFed 2MiceScapularis ticksLarval I. scapularisEngorgement weightSolitary miceDifferent parasitesUnfed ticksTicksContinuous infestationI. scapularisGroupFeeding successTick density
1997
Feeding Density Influences Acquisition of Borrelia burgdorferi in Larval Ixodes scapularis (Acari: Ixodidae)
Levin M, Papero M, Fish D. Feeding Density Influences Acquisition of Borrelia burgdorferi in Larval Ixodes scapularis (Acari: Ixodidae). Journal Of Medical Entomology 1997, 34: 569-572. PMID: 9379464, DOI: 10.1093/jmedent/34.5.569.Peer-Reviewed Original ResearchConceptsPrevalence of infectionBorrelia burgdorferi transmissionConsecutive weeksLarval Ixodes scapularisSpirochete prevalenceBorrelia burgdorferiB. burgdorferiLarval I. scapularisInfluences acquisitionPrevalenceBurgdorferiIxodes scapularisWhite-footed mouseIxodes scapularis SayI. scapularisEfficiency of acquisitionI. scapularis populationsInfectionMiceTransmission of the Agent of Human Granulocytic Ehrlichiosis by Host-Seeking Ixodus scapularis (Acari: Ixodidae) in Southern New York State
Vignes F, Fish D. Transmission of the Agent of Human Granulocytic Ehrlichiosis by Host-Seeking Ixodus scapularis (Acari: Ixodidae) in Southern New York State. Journal Of Medical Entomology 1997, 34: 379-382. PMID: 9220669, DOI: 10.1093/jmedent/34.4.379.Peer-Reviewed Original ResearchConceptsHuman granulocytic ehrlichiosisGranulocytic ehrlichiosisXenodiagnostic larvaeUninfected micePolymerase chain reaction analysisI. scapularis ticksChain reaction analysisBlood smearsHGE agentLyme diseaseMiceWhole bloodInfectionScapularis ticksMicroscopic examinationEhrlichiosisBorrelia burgdorferi JohnsonSouthern New York StateReaction analysisAgentsIxodes scapularisNew York StateWestchester CountyI. scapularisNatural foci
1996
Novel Borrelia burgdorferi isolates from Ixodes scapularis and Ixodes dentatus ticks feeding on humans
Anderson JF, Flavell RA, Magnarelli LA, Barthold SW, Kantor FS, Wallich R, Persing DH, Mathiesen D, Fikrig E. Novel Borrelia burgdorferi isolates from Ixodes scapularis and Ixodes dentatus ticks feeding on humans. Journal Of Clinical Microbiology 1996, 34: 524-529. PMID: 8904407, PMCID: PMC228839, DOI: 10.1128/jcm.34.3.524-529.1996.Peer-Reviewed Original ResearchConceptsLate Lyme diseaseBorrelia burgdorferiScapularis ticksPulsed-field gel electrophoresis patternsWhite-footed miceIxodes scapularis ticksB. burgdorferi sensu strictoI. scapularis ticksBurgdorferi sensu strictoLyme diseaseMonoclonal antibodiesGel electrophoresis patternsI. scapularisRestriction fragment length polymorphismFragment length polymorphismMicePrevious isolatesZS7Strain B31
1995
Increase in Abundance of Immature Ixodes scapularis (Acari: Ixodidae) in an Emergent Lyme Disease Endemic Area
Falco R, Daniels T, Fish D. Increase in Abundance of Immature Ixodes scapularis (Acari: Ixodidae) in an Emergent Lyme Disease Endemic Area. Journal Of Medical Entomology 1995, 32: 522-526. PMID: 7650715, DOI: 10.1093/jmedent/32.4.522.Peer-Reviewed Original Research
1993
Reduced Abundance of Ixodes scapularis (Acari: Ixodidae) and Lyme Disease Risk by Deer Exclusion
Daniels T, Fish D, Schwartz I. Reduced Abundance of Ixodes scapularis (Acari: Ixodidae) and Lyme Disease Risk by Deer Exclusion. Journal Of Medical Entomology 1993, 30: 1043-1049. PMID: 8271246, DOI: 10.1093/jmedent/30.6.1043.Peer-Reviewed Original Research
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