2018
GalT‐KO pig lungs are highly susceptible to acute vascular rejection in baboons, which may be mitigated by transgenic expression of hCD47 on porcine blood vessels
Watanabe H, Sahara H, Nomura S, Tanabe T, Ekanayake‐Alper D, Boyd L, Louras N, Asfour A, Danton M, Ho S, Arn S, Hawley R, Shimizu A, Nagayasu T, Ayares D, Lorber M, Sykes M, Sachs D, Yamada K. GalT‐KO pig lungs are highly susceptible to acute vascular rejection in baboons, which may be mitigated by transgenic expression of hCD47 on porcine blood vessels. Xenotransplantation 2018, 25: e12391. PMID: 29527745, PMCID: PMC6135720, DOI: 10.1111/xen.12391.Peer-Reviewed Original ResearchConceptsNon-surviving animalsHCD47Pig lungTransgene expressionLung graftsPorcineLung graft survivalDaysAssociated with early graft lossPodsAcute humoral rejectionWeaningSwineEarly graft lossAcute vascular rejectionGalT-KOHumoral rejectionGraft lossGraft survivalFemoral cathetersVascular rejectionPOD 7Hemorrhagic changesLeft lungFollow-up
2011
Contributions of Direct and Indirect Alloresponses to Chronic Rejection of Kidney Allografts in Nonhuman Primates
Nadazdin O, Boskovic S, Wee S, Sogawa H, Koyama I, Colvin R, Smith R, Tocco G, O’Connor D, Karl J, Madsen J, Sachs D, Kawai T, Cosimi A, Benichou G. Contributions of Direct and Indirect Alloresponses to Chronic Rejection of Kidney Allografts in Nonhuman Primates. The Journal Of Immunology 2011, 187: 4589-4597. PMID: 21957140, PMCID: PMC3197941, DOI: 10.4049/jimmunol.1003253.Peer-Reviewed Original ResearchConceptsChronic humoral rejectionT cell alloresponsesChronic rejectionIndirect alloresponseTolerant monkeysAlloantibody productionIndirect T cell responsesChronic rejection of kidney allograftsAlloresponses in vitroAnti-donor AbsT cell responsesAllogeneic organ transplantationDonor-SpecificRejection of kidney transplantsIndirect alloreactivityAlloantibody responseTolerant recipientsMarrow allograftsHumoral rejectionImmunosuppressive treatmentKidney allograftsPeriod posttransplantationT cellsAlloresponseKidney transplantation
2007
Effect of Inhaled Tacrolimus on Cellular and Humoral Rejection to Prevent Posttransplant Obliterative Airway Disease
Schrepfer S, Deuse T, Reichenspurner H, Hoffmann J, Haddad M, Fink J, Fischbein M, Robbins R, Pelletier M. Effect of Inhaled Tacrolimus on Cellular and Humoral Rejection to Prevent Posttransplant Obliterative Airway Disease. American Journal Of Transplantation 2007, 7: 1733-1742. PMID: 17532751, DOI: 10.1111/j.1600-6143.2007.01858.x.Peer-Reviewed Original ResearchConceptsObliterative airway diseaseTreatment groupsAirway diseaseSystemic side effectsCellular immune activationOrthotopic tracheal transplantationGraft infiltrationCellular rejectionCellular immunosuppressionHumoral rejectionAllograft rejectionElevated BUNImmune activationTacrolimusAerosol inhalationMononuclear infiltrationSide effectsPOD 8Tracheal transplantationAirway graftsPO animalsHistology of graftsGraftTreatmentPods
1995
Monitoring of allograft recipients for the development of HLA‐specific antibodies: Elimination of OKT3 as a complicating factor
Mulligan D, Gentry L, Dombrausky L, Klintmalm G, Nikaein A. Monitoring of allograft recipients for the development of HLA‐specific antibodies: Elimination of OKT3 as a complicating factor. Clinical Transplantation 1995, 9: 438-441. PMID: 8645885, DOI: 10.1111/j.1399-0012.1995.tb00363.x.Peer-Reviewed Original ResearchConceptsOKT3 MoAbPatient seraPanel reactive antibody (PRA) assayPositive reactivityAnti-HLA antibodiesHLA-specific antibodiesOKT3 monoclonal antibodyFalse-positive reactivityMismanagement of patientsAllograft recipientsHumoral rejectionTransplant recipientsAntibody assaysRabbit antimouse immunoglobulinAntibody developmentMonoclonal antibodiesMoAbSerumAntibodiesAntimouse immunoglobulinRecipientsComplicating factorsOKT3PatientsImmunoglobulin
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