2018
GalT‐KO pig lungs are highly susceptible to acute vascular rejection in baboons, which may be mitigated by transgenic expression of hCD47 on porcine blood vessels
Watanabe H, Sahara H, Nomura S, Tanabe T, Ekanayake‐Alper D, Boyd L, Louras N, Asfour A, Danton M, Ho S, Arn S, Hawley R, Shimizu A, Nagayasu T, Ayares D, Lorber M, Sykes M, Sachs D, Yamada K. GalT‐KO pig lungs are highly susceptible to acute vascular rejection in baboons, which may be mitigated by transgenic expression of hCD47 on porcine blood vessels. Xenotransplantation 2018, 25: e12391. PMID: 29527745, PMCID: PMC6135720, DOI: 10.1111/xen.12391.Peer-Reviewed Original ResearchConceptsNon-surviving animalsHCD47Pig lungTransgene expressionLung graftsPorcineLung graft survivalDaysAssociated with early graft lossPodsAcute humoral rejectionWeaningSwineEarly graft lossAcute vascular rejectionGalT-KOHumoral rejectionGraft lossGraft survivalFemoral cathetersVascular rejectionPOD 7Hemorrhagic changesLeft lungFollow-up
2007
Effect of Inhaled Tacrolimus on Cellular and Humoral Rejection to Prevent Posttransplant Obliterative Airway Disease
Schrepfer S, Deuse T, Reichenspurner H, Hoffmann J, Haddad M, Fink J, Fischbein M, Robbins R, Pelletier M. Effect of Inhaled Tacrolimus on Cellular and Humoral Rejection to Prevent Posttransplant Obliterative Airway Disease. American Journal Of Transplantation 2007, 7: 1733-1742. PMID: 17532751, DOI: 10.1111/j.1600-6143.2007.01858.x.Peer-Reviewed Original ResearchConceptsObliterative airway diseaseTreatment groupsAirway diseaseSystemic side effectsCellular immune activationOrthotopic tracheal transplantationGraft infiltrationCellular rejectionCellular immunosuppressionHumoral rejectionAllograft rejectionElevated BUNImmune activationTacrolimusAerosol inhalationMononuclear infiltrationSide effectsPOD 8Tracheal transplantationAirway graftsPO animalsHistology of graftsGraftTreatmentPods
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