2021
Expression of human CD47 in pig glomeruli prevents proteinuria and prolongs graft survival following pig‐to‐baboon xenotransplantation
Takeuchi K, Ariyoshi Y, Shimizu A, Okumura Y, Cara‐Fuentes G, Garcia G, Pomposelli T, Watanabe H, Boyd L, Ekanayake‐Alper D, Amarnath D, Sykes M, Sachs D, Johnson R, Yamada K. Expression of human CD47 in pig glomeruli prevents proteinuria and prolongs graft survival following pig‐to‐baboon xenotransplantation. Xenotransplantation 2021, 28: e12708. PMID: 34418164, PMCID: PMC8957703, DOI: 10.1111/xen.12708.Peer-Reviewed Original ResearchConceptsDevelopment of proteinuriaKidney graftsRenal tubular cellsGlomerular cellsTubular cellsNephrotic syndromeHuman CD47Transgene expressionPig-to-baboon xenotransplantationBone marrow transplantationDestructive inflammatory responseUpregulation of CD80Pig-to-baboonSMPDL-3bPigsMarrow transplantationGalT-KOGraft survivalProlonged survivalAntibody administrationThymic graftsHCD47Kidney xenotransplantationVascularized thymic graftsGroup B
2020
Antibody reactivity with new antigens revealed in multi‐transgenic triple knockout pigs may cause early loss of pig kidneys in baboons
Ariyoshi Y, Takeuchi K, Pomposelli T, Ekanayake‐Alper D, Shimizu A, Boyd L, Estime E, Ohta M, Asfour A, Arn J, Ayares D, Lorber M, Sykes M, Sachs D, Yamada K. Antibody reactivity with new antigens revealed in multi‐transgenic triple knockout pigs may cause early loss of pig kidneys in baboons. Xenotransplantation 2020, 28: e12642. PMID: 32909301, PMCID: PMC8957702, DOI: 10.1111/xen.12642.Peer-Reviewed Original ResearchConceptsPeripheral blood mononuclear cellsCytidine monophospho-N-acetylneuraminic acid hydroxylaseEndothelial protein C receptorTransgenic pigsMulti-transgenesPigsPre-screening assayPig kidneyGene editing technologyPig-to-baboonRenal functionKO pigsEditing technologyVascularized thymic graftsBaboon seraKnockout pigsStable renal functionGalT-KOHuman thrombomodulinMaintained renal functionBlood mononuclear cellsAcute xenograft rejectionProtein C receptorGenetic manipulationNatural antibodies
2018
Transgenic Expression of hCD47 on Vessels in Porcine GalTKO Lung Grafts in Baboons may Mitigate Acute Vascular Rejection in Baboons
Watanabe H, Nomura S, Sahara H, Pomposelli T, Ariyoshi Y, Boyd L, Ekanayake-Alper D, Tanabe T, Glor H, Arn S, Hawley R, Shimizu A, Ayares D, Lorber M, Sykes M, Sachs D, Yamada K. Transgenic Expression of hCD47 on Vessels in Porcine GalTKO Lung Grafts in Baboons may Mitigate Acute Vascular Rejection in Baboons. Transplantation 2018, 102: s313. DOI: 10.1097/01.tp.0000543035.62185.da.Peer-Reviewed Original ResearchGalT‐KO pig lungs are highly susceptible to acute vascular rejection in baboons, which may be mitigated by transgenic expression of hCD47 on porcine blood vessels
Watanabe H, Sahara H, Nomura S, Tanabe T, Ekanayake‐Alper D, Boyd L, Louras N, Asfour A, Danton M, Ho S, Arn S, Hawley R, Shimizu A, Nagayasu T, Ayares D, Lorber M, Sykes M, Sachs D, Yamada K. GalT‐KO pig lungs are highly susceptible to acute vascular rejection in baboons, which may be mitigated by transgenic expression of hCD47 on porcine blood vessels. Xenotransplantation 2018, 25: e12391. PMID: 29527745, PMCID: PMC6135720, DOI: 10.1111/xen.12391.Peer-Reviewed Original ResearchConceptsNon-surviving animalsHCD47Pig lungTransgene expressionLung graftsPorcineLung graft survivalDaysAssociated with early graft lossPodsAcute humoral rejectionWeaningSwineEarly graft lossAcute vascular rejectionGalT-KOHumoral rejectionGraft lossGraft survivalFemoral cathetersVascular rejectionPOD 7Hemorrhagic changesLeft lungFollow-up
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