2025
Predictive Validity and Treatment Sensitivity of the Death-Implicit Association Test (D-IAT) During Inpatient Treatment and Across a 6-Month Follow-Up Period
Levy H, Lord K, Rice T, Sain K, Stubbing J, Diefenbach G, Tolin D. Predictive Validity and Treatment Sensitivity of the Death-Implicit Association Test (D-IAT) During Inpatient Treatment and Across a 6-Month Follow-Up Period. Cognitive Therapy And Research 2025, 1-10. DOI: 10.1007/s10608-024-10564-z.Peer-Reviewed Original ResearchDeath Implicit Association TestSuicidal thoughtsInpatient treatmentFrequency of suicidal behaviorAssociation TestCognitive-behavioral therapyHigh risk of suicidePsychiatric inpatient unitTreatment sensitivitySample of inpatientsRisk of suicideImplicit cognitionSuicidal behaviorSuicide riskPredictive validitySuicide preventionDetect treatment effectsInpatient unitSuicideFollow-up periodPeriod post-dischargeInpatientsTreatment effectsThoughtsInpatient admissions
2024
Rare germline variants in cancer-relevant genes are associated with breast cancer risk in young women with high-risk family history
Rozenblit M, Qing T, Ye Y, Zhao H, Hofstatter E, Singh V, Reisenbichler E, Murray M, Pusztai L. Rare germline variants in cancer-relevant genes are associated with breast cancer risk in young women with high-risk family history. Breast Cancer Research And Treatment 2024, 209: 21-26. PMID: 39602012, DOI: 10.1007/s10549-024-07560-y.Peer-Reviewed Original ResearchHigh-risk family historyFamily historyRare germline variantsCancer riskSNP-set kernel association testAssociated with breast cancer riskCancer casesContribution of family historyEarly-onset breast cancerCancer prevention clinicBreast cancerBreast cancer riskKernel association testBreast cancer casesCancer-predisposing genesGermline variantsGermline pathogenic variantsYoung womenPrevention clinicSKAT-OBurden testsPathogenic variantsExome sequencing dataAssociation TestLevel alterationsA genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychopathology
Gupta P, Galimberti M, Liu Y, Beck S, Wingo A, Wingo T, Adhikari K, Kranzler H, Stein M, Gelernter J, Levey D. A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychopathology. Nature Human Behaviour 2024, 8: 2235-2249. PMID: 39134740, PMCID: PMC11576509, DOI: 10.1038/s41562-024-01951-3.Peer-Reviewed Original ResearchPersonality traitsPsychiatric traitsBidirectional effectsGenetic architectureHuman personality traitsGenetic correlation analysisGene-based association testsGenome-wide significant lociNeuroticismAgreeablenessGenome-wide association studiesGenome-wide association study meta-analysisMental illnessGenome-wide investigationAssociation TestComplex human traitsProteome-wide analysisAnxietyDepressionExtraversionConscientiousnessExpression of genesNovel lociSignificant lociTranscriptome-wideRacial Implicit Associations in Child Psychiatry
Malison K, Avila-Quintero V, Al-Mateen C, Flores J, Landeros-Weisenberger A, Njoroge W, Novins D, Robles-Ramamurthy B, Taylor J, Bloch M, Tobón A. Racial Implicit Associations in Child Psychiatry. Journal Of The American Academy Of Child & Adolescent Psychiatry 2024, 64: 734-744. PMID: 38823476, DOI: 10.1016/j.jaac.2024.04.013.Peer-Reviewed Original ResearchImplicit Association TestRace Implicit Association TestRecruitment of human participantsExternalizing behavior problemsPaper self-identifiesImplicit associationsChildren faceBehavior problemsChild psychiatryAbstractText Label="DIVERSITY &Negatively valenced wordsExternal wordHuman participantsValenced wordsExternalizing disordersParticipating psychiatristsPsychiatric cliniciansNegative valenceNegative wordsPsychiatristsAssociation TestPsychiatryInvestigate psychiatristsReduce racial inequalityDemographic predictorsGenetic polymorphisms associated with adverse pregnancy outcomes in nulliparas
Khan R, Guerrero R, Wapner R, Hahn M, Raja A, Salleb-Aouissi A, Grobman W, Simhan H, Silver R, Chung J, Reddy U, Radivojac P, Pe’er I, Haas D. Genetic polymorphisms associated with adverse pregnancy outcomes in nulliparas. Scientific Reports 2024, 14: 10514. PMID: 38714721, PMCID: PMC11076516, DOI: 10.1038/s41598-024-61218-9.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesAdverse pregnancy outcomesMulti-ancestry genome-wide association studyCluster of SNPsGestational diabetesPregnancy outcomesAdmixed AmericansNovel lociPregnancy lossAssociation studiesGenetic markersIncreased risk of pregnancy lossTRMU geneGenetic ancestryAssociated with gestational diabetesRisk of pregnancy lossSub-cohortProportion of pregnanciesCause of morbidityLociAssociation TestSNPsPreterm birthMaternal riskIncreased riskWanting-liking dissociation and altered dopaminergic functioning: Similarities between internet gaming disorder and tobacco use disorder
Ma X, Wang M, Zhou W, Zhang Z, Ni H, Jiang A, Zheng Y, Du X, Potenza M, Dong G. Wanting-liking dissociation and altered dopaminergic functioning: Similarities between internet gaming disorder and tobacco use disorder. Journal Of Behavioral Addictions 2024, 13: 596-609. PMID: 38635338, PMCID: PMC11220823, DOI: 10.1556/2006.2024.00011.Peer-Reviewed Original ResearchInternet gaming disorderTobacco use disorderIGD participantsGaming disorderCue-craving taskImplicit Association TestBrain-behavior mechanismsHealthy control participantsImplicit association test resultsFunctional MRI dataNeuromelanin-sensitive MRIIncentive sensitizationAddiction severityDopaminergic involvementDSM-5Dopaminergic functionDopaminergic systemPotential dissociationUse disorderControl participantsBrain featuresHedonic responsesAssociation TestGaming motivesNeural featuresUtility of the Death-Implicit Association Test in a Sample of Suicidal Inpatients
Lord K, Rice T, Levy H, Sain K, Stubbing J, Diefenbach G, Tolin D. Utility of the Death-Implicit Association Test in a Sample of Suicidal Inpatients. Cognitive Therapy And Research 2024, 48: 426-434. DOI: 10.1007/s10608-024-10465-1.Peer-Reviewed Original ResearchDeath Implicit Association TestSuicide riskD scoreSample of psychiatric inpatientsMeasures of suicide riskAssessment of suicide riskAssociation TestIndicators of suicide riskLifetime suicide attemptsMethodThe present studySuicidal cognitionsPsychiatric inpatientsSuicidal ideationExplicit measuresSuicide attemptsAttempted SuicideInconsistent findingsPositive scoresDD scoresPresent studyAssociated with lifeIdeationSelf-IdentificationHopelessnessCognition
2023
Using Behavioral Measures to Assess Suicide Risk in the Psychiatric Emergency Department for Youth
Shin K, Baroni A, Gerson R, Bell K, Pollak O, Tezanos K, Spirito A, Cha C. Using Behavioral Measures to Assess Suicide Risk in the Psychiatric Emergency Department for Youth. Child Psychiatry & Human Development 2023, 55: 1475-1486. PMID: 36821015, DOI: 10.1007/s10578-023-01507-y.Peer-Reviewed Original ResearchConceptsImplicit Association TestMeasures of suicide riskSuicide stroop taskBehavioral measuresSuicide riskStroop taskSuicidal ideationSuicide attemptsAttempted SuicideWithin-person effectsAssess suicide riskLevels of distressSuicide-related reasonsBehavioral tasksSuicidal thoughtsPsychiatric EDIncreased distressSelf-ReportSuicide screeningAssociation TestSuicideComposite scoreDemographic covariatesIdeationYouth
2022
Whole exome sequencing in dense families suggests genetic pleiotropy amongst Mendelian and complex neuropsychiatric syndromes
Ganesh S, Vemula A, Bhattacharjee S, Mathew K, Ithal D, Navin K, Nadella R, Viswanath B, Sullivan P, Jain S, Purushottam M. Whole exome sequencing in dense families suggests genetic pleiotropy amongst Mendelian and complex neuropsychiatric syndromes. Scientific Reports 2022, 12: 21128. PMID: 36476812, PMCID: PMC9729597, DOI: 10.1038/s41598-022-25664-7.Peer-Reviewed Original ResearchConceptsSequence kernel association testKernel association testWhole-exome sequencing studiesExome sequencing studiesUnique genesGenetic architectureCase-control association analysisDeleterious variantsSequencing studiesWhole-exome sequencingMendelian syndromesAssociation analysisCriteria of rarityPleiotropic influenceGenesWES studyFunctional consequencesSignificant overrepresentationGenetic pleiotropyExome sequencingAffected individualsFamilyImportant insightsUnrelated controlsAssociation TestIncorporating family disease history and controlling case–control imbalance for population-based genetic association studies
Zhuang Y, Wolford B, Nam K, Bi W, Zhou W, Willer C, Mukherjee B, Lee S. Incorporating family disease history and controlling case–control imbalance for population-based genetic association studies. Bioinformatics 2022, 38: 4337-4343. PMID: 35876838, PMCID: PMC9477535, DOI: 10.1093/bioinformatics/btac459.Peer-Reviewed Original ResearchConceptsEmpirical saddlepoint approximationFamily disease historyCase-control imbalanceSaddlepoint approximationGenome-wide association analysisPopulation-based genetic association studiesGenetic association testsVariant-phenotype associationsDisease historyGenetic association studiesLow detection powerType I error inflationCorrelation of phenotypesWhite British sampleSupplementary dataAssociation studiesPopulation-based biobanksIncreased phenotypic correlationsKorean GenomeSimulation studyPhenotype distributionPhenotypeAssociation TestBioinformaticsPhenotypic correlations
2021
Best research practices for using the Implicit Association Test
Greenwald A, Brendl M, Cai H, Cvencek D, Dovidio J, Friese M, Hahn A, Hehman E, Hofmann W, Hughes S, Hussey I, Jordan C, Kirby T, Lai C, Lang J, Lindgren K, Maison D, Ostafin B, Rae J, Ratliff K, Spruyt A, Wiers R. Best research practices for using the Implicit Association Test. Behavior Research Methods 2021, 54: 1161-1180. PMID: 34519017, PMCID: PMC9170636, DOI: 10.3758/s13428-021-01624-3.Peer-Reviewed Original ResearchEfficient mixed model approach for large-scale genome-wide association studies of ordinal categorical phenotypes
Bi W, Zhou W, Dey R, Mukherjee B, Sampson J, Lee S. Efficient mixed model approach for large-scale genome-wide association studies of ordinal categorical phenotypes. American Journal Of Human Genetics 2021, 108: 825-839. PMID: 33836139, PMCID: PMC8206161, DOI: 10.1016/j.ajhg.2021.03.019.Peer-Reviewed Original ResearchConceptsOrdinal categorical phenotypesGenome-wide association studiesCategorical phenotypesGenome-wide significant variantsRare variantsPhenotype distributionControlled type I error ratesType I error rateMixed model approachArray genotypingAssociation studiesCommon variantsQuantitative traitsSignificant variantsLogistic mixed modelsLack of analysis toolsUK BiobankLinear mixed model approachPhenotypeAssociation TestVariantsMixed modelsSignificance levelMAFTraits
2020
Applied Racial/Ethnic Healthcare Disparities Research Using Implicit Measures.
Hagiwara N, Dovidio J, Stone J, Penner L. Applied Racial/Ethnic Healthcare Disparities Research Using Implicit Measures. Social Cognition 2020, 38: s68-s97. PMID: 34103783, PMCID: PMC8183978, DOI: 10.1521/soco.2020.38.supp.s68.Peer-Reviewed Original ResearchImplicit Association TestProvider implicit biasImplicit biasImplicit measuresHealthcare disparities researchImplicit social cognitionSocial cognition researchSocial cognitionImplicit prejudiceCognition researchAssociation TestEthnic healthcare disparitiesSuch associationsBiasCognitionResearchTreatment recommendationsDisparities researchMeasuresPrejudiceLittle evidenceOngoing controversyHealth disparities researchSuch effortsPatient communicationImplicit androcentrism: Men are human, women are gendered
Bailey A, LaFrance M, Dovidio J. Implicit androcentrism: Men are human, women are gendered. Journal Of Experimental Social Psychology 2020, 89: 103980. DOI: 10.1016/j.jesp.2020.103980.Peer-Reviewed Original ResearchImplicit Association TestGender differencesCertain social rolesCognitive processesExamples of humanityTheoretical accountsAssociation TestHuman conceptsAndrocentric tendencySocial rolesMale participantsParticipantsSemantic redundancySensitive topicsGender biasPeopleSame redundancyMale respondentsAndrocentrismPresent studyWomenMenPersonsLabelsBiasA genome-wide association study of cocaine use disorder accounting for phenotypic heterogeneity and gene–environment interaction
Sun J, Kranzler HR, Gelernter J, Bi J. A genome-wide association study of cocaine use disorder accounting for phenotypic heterogeneity and gene–environment interaction. Journal Of Psychiatry And Neuroscience 2020, 45: 34-44. PMID: 31490055, PMCID: PMC6919916, DOI: 10.1503/jpn.180098.Peer-Reviewed Original ResearchConceptsGenetic lociGenome-wide association testsPhenotypic heterogeneityNew genetic lociGenetic variantsWide association studyGene-environment interplayNovel genetic variantsHigh heritability estimatesSignificant genomeReplication sampleSingle nucleotide polymorphismsGenetic variationAssociation studiesLociNucleotide polymorphismsAssociation TestHeritability estimatesGene-environment interactionsReplication resultsCluster analysisEnvironmental factorsTRAK2GenomeDiscovery phase
2019
Retrospective Association Analysis of Longitudinal Binary Traits Identifies Important Loci and Pathways in Cocaine Use
Wu W, Wang Z, Xu K, Zhang X, Amei A, Gelernter J, Zhao H, Justice AC, Wang Z. Retrospective Association Analysis of Longitudinal Binary Traits Identifies Important Loci and Pathways in Cocaine Use. Genetics 2019, 213: 1225-1236. PMID: 31591132, PMCID: PMC6893384, DOI: 10.1534/genetics.119.302598.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesAssociation analysisGenome-wide association analysisCase-control genome-wide association studyPhenotype model misspecificationImportant locusGenetic architectureComplex traitsGenetic association analysisGene mappingGenome scanPathway analysisAssociation studiesAxonal guidanceGenetic variantsBinary traitsAssociation TestElectronic health record-based studiesPathwayImportant pathwayLociTraitsPhenotype distributionLongitudinal phenotypesPhenotype63 TRANSCRIPTOMIC IMPUTATION ANALYSIS IN ANOREXIA NERVOSA IDENTIFIES BOTH METABOLIC AND PSYCHIATRIC AETIOLOGIES
Huckins L, Dobbyn A, Thornton L, Group of the PGC E, Devlin B, Sieberts S, Cox N, Im H, Breen G, Sklar P, Bulik C, Stahl E. 63 TRANSCRIPTOMIC IMPUTATION ANALYSIS IN ANOREXIA NERVOSA IDENTIFIES BOTH METABOLIC AND PSYCHIATRIC AETIOLOGIES. European Neuropsychopharmacology 2019, 29: s818. DOI: 10.1016/j.euroneuro.2017.08.064.Peer-Reviewed Original ResearchGene-tissue associationsTranscriptome imputationCommonMind ConsortiumGene expression prediction modelsGenome-wide significant lociTissue-specific gene expressionExpression prediction modelsMetabolic tissuesCaudate basal gangliaSignificant lociGenotype dataCharacterization of AnGene associationsReference panelGene expressionAetiology of ANMetabolic phenotypeMolecular pathwaysGenetic correlationsAssociation TestPsychiatric disordersAN riskMetabolic systemsImputation analysisBackground Anorexia nervosa
2018
Testing Mood-Activated Psychological Markers for Suicidal Ideation
B. C, O’Connor R, Kirtley O, Cleare S, Wetherall K, Eschle S, Tezanos K, Nock M. Testing Mood-Activated Psychological Markers for Suicidal Ideation. Journal Of Psychopathology And Clinical Science 2018, 127: 448-457. PMID: 29927267, DOI: 10.1037/abn0000358.Peer-Reviewed Original ResearchConceptsNegative mood inductionImplicit Association TestSuicidal ideationPsychological processesMood inductionDepressive symptomsSuicide stroop taskLikelihood of suicidal ideationBaseline suicidal ideationDifferential activation hypothesisFunction of moodPsychological risk factorsMeasuring psychological processesStroop taskIAT performanceTransient moodStroop scoresNegative moodSuicidal individualsImplicit identificationIdeationPsychological markersMoodActivation hypothesisAssociation TestThe validation of Implicit Association Test measures for smartphone and Internet addiction in at-risk children and adolescents
Roh D, Bhang SY, Choi JS, Kweon YS, Lee SK, Potenza MN. The validation of Implicit Association Test measures for smartphone and Internet addiction in at-risk children and adolescents. Journal Of Behavioral Addictions 2018, 7: 79-87. PMID: 29383939, PMCID: PMC6035023, DOI: 10.1556/2006.7.2018.02.Peer-Reviewed Original ResearchConceptsImplicit Association TestSmartphone addictionImplicit associationsInternet addictionImplicit Association Test (IAT) measuresRisk childrenMental healthFeatures of addictionResults Significant correlationsMeasures of InternetDaily stress levelsImpulsive tendenciesExplicit processesProblem behaviorDaily stressAssociation TestTest measuresGood convergentDiscriminant validityMultiple regression analysisInternet gamesStandardized scalesAdolescentsQuality of lifeAddiction
2017
Rare‐variant association tests in longitudinal studies, with an application to the Multi‐Ethnic Study of Atherosclerosis (MESA)
He Z, Lee S, Zhang M, Smith J, Guo X, Palmas W, Kardia S, Ionita‐Laza I, Mukherjee B. Rare‐variant association tests in longitudinal studies, with an application to the Multi‐Ethnic Study of Atherosclerosis (MESA). Genetic Epidemiology 2017, 41: 801-810. PMID: 29076270, PMCID: PMC5696115, DOI: 10.1002/gepi.22081.Peer-Reviewed Original ResearchConceptsMulti-Ethnic Study of AtherosclerosisMulti-Ethnic StudyStudy of atherosclerosisType I error rateRare-variant association testsRare variantsGene-based association testsRare-variant associationsAssociation TestLongitudinal outcomesLongitudinal studyExome sequencing dataMeasurement of blood pressureGenomic regionsSequence dataTrait heritabilitySequencing studiesMeasured outcomesGenetic variantsVariant analysisModerate sample sizesIndividual variantsRobust to misspecificationWithin-subject correlationStatistical power
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