2018
SHROOM3-FYN Interaction Regulates Nephrin Phosphorylation and Affects Albuminuria in Allografts
Wei C, Banu K, Garzon F, Basgen JM, Philippe N, Yi Z, Liu R, Choudhuri J, Fribourg M, Liu T, Cumpelik A, Wong J, Khan M, Das B, Keung K, Salem F, Campbell KN, Kaufman L, Cravedi P, Zhang W, O'Connell PJ, He JC, Murphy B, Menon MC. SHROOM3-FYN Interaction Regulates Nephrin Phosphorylation and Affects Albuminuria in Allografts. Journal Of The American Society Of Nephrology 2018, 29: 2641-2657. PMID: 30341149, PMCID: PMC6218856, DOI: 10.1681/asn.2018060573.Peer-Reviewed Original ResearchMeSH KeywordsActin CytoskeletonAdolescentAdultAgedAlbuminuriaAllograftsAnimalsChildChild, PreschoolEnhancer Elements, GeneticFemaleGene Knockdown TechniquesGlomerular Filtration RateHomozygoteHumansKidneyKidney TransplantationMaleMembrane ProteinsMiceMice, 129 StrainMice, Inbred C57BLMice, KnockoutMicrofilament ProteinsMiddle AgedPhosphorylationPodocytesPolymorphism, Single NucleotideProto-Oncogene Proteins c-fynRenal Insufficiency, ChronicRNA, Small InterferingSignal Transductionsrc Homology DomainsYoung AdultConceptsDiffuse foot process effacementKnockdown miceFoot process effacementReduced albuminuriaAllograft fibrosisRenal functionDonor kidneysLower GFRRenal fibrosisTGF-b signalingHuman allograftsNephroseq databaseBiopsy samplesProcess effacementProtective roleAlbuminuriaAdult glomeruliHuman podocytesKnockdown podocytesCKDHuman dataPodocytesAllograftsActin cytoskeleton pathwayFibrosisInterferon-γ converts human microvascular pericytes into negative regulators of alloimmunity through induction of indoleamine 2,3-dioxygenase 1
Liu R, Merola J, Manes TD, Qin L, Tietjen GT, López-Giráldez F, Broecker V, Fang C, Xie C, Chen PM, Kirkiles-Smith NC, Jane-Wit D, Pober JS. Interferon-γ converts human microvascular pericytes into negative regulators of alloimmunity through induction of indoleamine 2,3-dioxygenase 1. JCI Insight 2018, 3: e97881. PMID: 29515027, PMCID: PMC5922286, DOI: 10.1172/jci.insight.97881.Peer-Reviewed Original ResearchMeSH KeywordsAllograftsAnimalsAntigen PresentationCell CommunicationCells, CulturedDisease Models, AnimalEndothelial CellsEndothelium, VascularFemaleGraft RejectionHealthy VolunteersHuman Umbilical Vein Endothelial CellsHumansIndoleamine-Pyrrole 2,3,-DioxygenaseInterferon-gammaIsoantigensMice, SCIDMicrovesselsPericytesPrimary Cell CultureRNA, Small InterferingSkinSkin TransplantationT-Lymphocytes, CytotoxicTransplantation ChimeraTransplantation, HomologousTryptophanConceptsInduction of indoleamineHuman pericytesEndothelial cellsAllograft rejectionTryptophan depletionT cellsAcute T cell-mediated rejectionT cell-mediated rejectionEffector memory T cellsDioxygenase 1Early acute rejectionCell-mediated rejectionSkin allograft rejectionAlloreactive T cellsHuman renal allograftsMemory T cellsRole of ECsContribution of pericytesAcute rejectionRenal allograftsImmunoregulatory effectsImmunosuppressive propertiesHuman allograftsMouse modelMicrovascular pericytes
2009
Development of a Humanized Mouse Model to Study the Role of Macrophages in Allograft Injury
Kirkiles-Smith NC, Harding MJ, Shepherd BR, Fader SA, Yi T, Wang Y, McNiff JM, Snyder EL, Lorber MI, Tellides G, Pober JS. Development of a Humanized Mouse Model to Study the Role of Macrophages in Allograft Injury. Transplantation 2009, 87: 189-197. PMID: 19155972, PMCID: PMC2776641, DOI: 10.1097/tp.0b013e318192e05d.Peer-Reviewed Original ResearchMeSH KeywordsAdoptive TransferAdult Stem CellsAnimalsAntigens, CDAntigens, CD34Antigens, Differentiation, MyelomonocyticArteriesDisease Models, AnimalGraft RejectionHematopoietic Stem Cell TransplantationHematopoietic Stem CellsHumansInterleukin Receptor Common gamma SubunitLipopolysaccharide ReceptorsMacrophagesMiceMice, Inbred NODMice, KnockoutMice, SCIDReceptors, Cell SurfaceSkinSkin TransplantationT-LymphocytesTransplantation, HomologousWhole-Body IrradiationConceptsT cellsImmunodeficient micePeripheral blood monuclear cellsHematopoietic stem cellsAllogeneic T cellsHuman cell engraftmentHumanized mouse modelHuman monocytes/macrophagesRole of macrophagesArterial interposition graftsMonocytes/macrophagesImmunodeficient mouse hostsStem cellsHuman skinAllograft injuryArtery graftAdoptive transferInterposition graftPeripheral bloodTransplant rejectionIntimal expansionHuman allograftsMouse modelCell engraftmentTissue graft
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