Methadone maintenance patients lack analgesic response to a cumulative intravenous dose of 32 mg of hydromorphone
Agin-Liebes G, Huhn A, Strain E, Bigelow G, Smith M, Edwards R, Gruber V, Tompkins D. Methadone maintenance patients lack analgesic response to a cumulative intravenous dose of 32 mg of hydromorphone. Drug And Alcohol Dependence 2021, 226: 108869. PMID: 34216862, PMCID: PMC9559787, DOI: 10.1016/j.drugalcdep.2021.108869.Peer-Reviewed Original ResearchConceptsQuantitative sensory testingDoses of hydromorphoneAcute intravenous (IVLevel of opioid toleranceAbuse liability effectsAbuse liability measuresExperimental pain paradigmDoses of opioidsMethadone-maintained individualsAcute pain managementCumulative intravenous dosesIntravenous (IVOpioid use disorderRandomized Controlled StudyMethadone maintenance patientsPlacebo-controlled conditionsAnalgesic indexEfficacy opioidsQST outcomesEscalating dosesOpioid tolerancePlacebo doseOral methadoneAnalgesic strategiesAnalgesic response
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