2025
Multi-Species Synbiotic Supplementation Enhances Gut Microbial Diversity, Increases Urolithin A and Butyrate Production, and Reduces Inflammation in Healthy Adults: A Randomized, Placebo-Controlled Trial
Napier B, Allegretti J, Feuerstadt P, Kelly C, Van Hise N, Jäger R, Kassam Z, Reid G. Multi-Species Synbiotic Supplementation Enhances Gut Microbial Diversity, Increases Urolithin A and Butyrate Production, and Reduces Inflammation in Healthy Adults: A Randomized, Placebo-Controlled Trial. Nutrients 2025, 17: 2734. PMID: 40944126, PMCID: PMC12430871, DOI: 10.3390/nu17172734.Peer-Reviewed Original ResearchConceptsPlacebo-controlled trialBiological functionsButyrate levelsButyrate-producing speciesGut microbial diversitySystemic inflammationFecal microbiome compositionFecal butyrate levelsMicrobiome-derived metabolitesUrolithin AButyrate producersAlpha diversityMicrobial diversityBeneficial microbesPrecursor metabolismProbiotic strainsButyrate productionMicrobiome compositionHealthy adultsBaseline day 0Fecal butyrateEnd-of-studyPlacebo-ControlledProbiotic supplementationSerum CRPGut microbial composition and diversity varies by CREBRF genotype among Samoan infants
Oyama S, Arslanian K, Savo Sardaro M, Duckham R, Kershaw E, Wood A, Fidow U, Naseri T, Reupena M, Amato K, Hawley N. Gut microbial composition and diversity varies by CREBRF genotype among Samoan infants. Physiological Genomics 2025, 57: 473-484. PMID: 40366801, PMCID: PMC12276851, DOI: 10.1152/physiolgenomics.00014.2024.Peer-Reviewed Original ResearchGut microbiotaMicrobiome compositionBacterial gene sequencesDifferentially abundant taxaGut microbial compositionGut microbial diversityMicrobiota community structureOverall microbiome compositionGut microbiome compositionGenotypic differencesDifferential abundance analysisImmune signaling pathwaysEscherichia-Shigella</i>,Low relative abundanceAbundant taxaGene sequencesGut microbiomeMicrobial diversityMicrobial compositionAssociated with functional differencesCommunity structureAssociated with lower relative abundanceMinor A alleleRelative abundanceMicrobiota
2024
Zearalenone-induced hepatointestinal toxicity in laying hens: unveiling the role of gut microbiota and fecal metabolites
Wang L, Deng Z, Huang J, Li T, Jiang J, Wang W, Sun Y, Deng Y. Zearalenone-induced hepatointestinal toxicity in laying hens: unveiling the role of gut microbiota and fecal metabolites. Poultry Science 2024, 103: 104221. PMID: 39241615, PMCID: PMC11406091, DOI: 10.1016/j.psj.2024.104221.Peer-Reviewed Original ResearchGut microbiotaGut microbial community compositionGut microbial diversityLaying hensMicrobial community compositionMetabolism of amino acidsNonribosomal peptidesCommunity compositionRRNA sequencingExacerbated liver damageFusarium speciesMicrobial diversityFirmicutes/Bacteroidetes ratioNucleic acid degradationInflammatory cell infiltrationABC transportersAspartate aminotransferaseEstrogenic disordersLactobacillus abundanceDecreased villus heightHigher abundanceMicrobiotaIntestinal oxidative stressZearalenone groupsAmino acidsGut Microbiome of Patients With Breast Cancer in Vietnam
Nguyen S, Tran H, Long J, Shrubsole M, Cai H, Yang Y, Nguyen L, Nguyen G, Nguyen C, Ta T, Wu J, Cai Q, Zheng W, Tran T, Shu X. Gut Microbiome of Patients With Breast Cancer in Vietnam. JCO Global Oncology 2024, 10: e2300234. PMID: 38359370, PMCID: PMC10881109, DOI: 10.1200/go.23.00234.Peer-Reviewed Original ResearchConceptsGut microbiome health indexGut microbiomeTaxa abundanceA-diversityUnhealthy gut microbiomeGut microbiome of patientsStool samplesShotgun metagenomic sequencingGut microbial diversityAbundance of speciesBreast cancerMicrobiome of patientsMetagenomic sequencingInvestigated taxaGut microbiotaB-diversityMicrobial diversityDiagnosis delayDecreased abundanceIncreased abundanceMicrobiomeHigher intake of fiberGutIntake of fiberTaxaGut microbiome in association with chemotherapy‐induced toxicities among patients with breast cancer
Nguyen S, Tran H, Long J, Shrubsole M, Cai H, Yang Y, Cai Q, Tran T, Zheng W, Shu X. Gut microbiome in association with chemotherapy‐induced toxicities among patients with breast cancer. Cancer 2024, 130: 2014-2030. PMID: 38319284, DOI: 10.1002/cncr.35229.Peer-Reviewed Original ResearchGut microbiomeChemotherapy-induced toxicityRisk of severe neutropeniaReductive tricarboxylic acid cycleMetabolic pathwaysGut microbial diversityTricarboxylic acid cycleSevere nausea/vomitingSevere neutropeniaBreast cancerFamily LachnospiraceaeIncreased risk of severe neutropeniaShotgun metagenomicsClass NegativicutesGut microbiotaB-diversityMicrobial diversityAcid cycleChao1 indexSevere hematologic toxicityA-diversityFirst-line treatmentMicrobiomeMultivariate logistic regressionGut
2017
Influence of Feeding Type on Gut Microbiome Development in Hospitalized Preterm Infants
Cong X, Judge M, Xu W, Diallo A, Janton S, Brownell E, Maas K, Graf J. Influence of Feeding Type on Gut Microbiome Development in Hospitalized Preterm Infants. Nursing Research 2017, 66: 123-133. PMID: 28252573, PMCID: PMC5334772, DOI: 10.1097/nnr.0000000000000208.Peer-Reviewed Original ResearchConceptsGut microbial colonizationMother's own milkPreterm infantsGut microbiomeMicrobial diversityDiversity of gut microbiomeFeeding typeGut microbial diversityGut microbiome developmentGut microbiome compositionMicrobial community patternsAbundance of EnterobacterialesIncreased microbial diversityDevelopment of preterm infantsAbundance of ClostridialesNeonatal intensive care unitBirth gestational ageStable preterm infantsRRNA genePostnatal day 0Community patternsMicrobiome compositionIntensive care unitMicrobial patternsMicrobiome development
2014
Analysis of Multiple Tsetse Fly Populations in Uganda Reveals Limited Diversity and Species-Specific Gut Microbiota
Aksoy E, Telleria EL, Echodu R, Wu Y, Okedi LM, Weiss BL, Aksoy S, Caccone A. Analysis of Multiple Tsetse Fly Populations in Uganda Reveals Limited Diversity and Species-Specific Gut Microbiota. Applied And Environmental Microbiology 2014, 80: 4301-4312. PMID: 24814785, PMCID: PMC4068677, DOI: 10.1128/aem.00079-14.Peer-Reviewed Original ResearchConceptsDifferent tsetse speciesRRNA gene clone librariesDifferent sympatric speciesGene clone librariesTsetse speciesLimited diversityQuantitative PCRV4 hypervariable regionGut microbiotaGut microbial abundanceSympatric speciesGut microbial diversityClone librariesMicrobial diversityMicrobial abundanceField fliesRRNA geneHost physiologyTsetse fly populationsDeep sequencingReduced diversityDifferent speciesFly populationsSpeciesWigglesworthia
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