2024
Zearalenone-induced hepatointestinal toxicity in laying hens: unveiling the role of gut microbiota and fecal metabolites
Wang L, Deng Z, Huang J, Li T, Jiang J, Wang W, Sun Y, Deng Y. Zearalenone-induced hepatointestinal toxicity in laying hens: unveiling the role of gut microbiota and fecal metabolites. Poultry Science 2024, 103: 104221. PMID: 39241615, PMCID: PMC11406091, DOI: 10.1016/j.psj.2024.104221.Peer-Reviewed Original ResearchGut microbiotaGut microbial community compositionGut microbial diversityLaying hensMicrobial community compositionMetabolism of amino acidsNonribosomal peptidesCommunity compositionRRNA sequencingExacerbated liver damageFusarium speciesMicrobial diversityFirmicutes/Bacteroidetes ratioNucleic acid degradationInflammatory cell infiltrationABC transportersAspartate aminotransferaseEstrogenic disordersLactobacillus abundanceDecreased villus heightHigher abundanceMicrobiotaIntestinal oxidative stressZearalenone groupsAmino acids
2019
Norovirus Changes Susceptibility to Type 1 Diabetes by Altering Intestinal Microbiota and Immune Cell Functions
Pearson JA, Tai N, Ekanayake-Alper DK, Peng J, Hu Y, Hager K, Compton S, Wong FS, Smith PC, Wen L. Norovirus Changes Susceptibility to Type 1 Diabetes by Altering Intestinal Microbiota and Immune Cell Functions. Frontiers In Immunology 2019, 10: 2654. PMID: 31798584, PMCID: PMC6863139, DOI: 10.3389/fimmu.2019.02654.Peer-Reviewed Original ResearchConceptsExpansion of TregsNOD miceT cellsMNV4 infectionMucosal immunityNon-obese diabetic (NOD) mouse modelGerm-free NOD miceFirmicutes/Bacteroidetes ratioProinflammatory T cellsRole of norovirusesTuft cell markersDevelopment of T1DInflammatory T cellsCommon enteric virusesB cell subsetsDiabetic mouse modelImmune cell functionType 1 diabetes susceptibilityEnteric virusesNaïve splenocytesT1D protectionTreg numbersImmunological changesMucosal antibodiesT1D development
2016
Weight Loss Decreases Inherent and Allergic Methacholine Hyperresponsiveness in Mouse Models of Diet-Induced Obese Asthma
Ather JL, Chung M, Hoyt LR, Randall MJ, Georgsdottir A, Daphtary NA, Aliyeva MI, Suratt BT, Bates JH, Irvin CG, Russell SR, Forgione PM, Dixon AE, Poynter ME. Weight Loss Decreases Inherent and Allergic Methacholine Hyperresponsiveness in Mouse Models of Diet-Induced Obese Asthma. American Journal Of Respiratory Cell And Molecular Biology 2016, 55: 176-187. PMID: 27064658, PMCID: PMC4979374, DOI: 10.1165/rcmb.2016-0070oc.Peer-Reviewed Original ResearchConceptsDiet-induced weight lossObese asthmaMethacholine hyperresponsivenessWeight lossAsthma phenotypesMouse modelBariatric surgery-induced weight lossSurgery-induced weight lossFirmicutes/Bacteroidetes ratioAllergic asthma phenotypeDietary weight lossObese-asthma phenotypeSurgical weight lossSuccessful weight lossElevated proinflammatory cytokinesCentral airway resistanceDiet-induced obesityEnvironmental allergen exposureAdaptive immune responsesSubstantial weight lossDistinct anatomical compartmentsMethacholine responsivenessAllergic asthmaAllergen exposureAsthma symptoms
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